公开(公告)号：US20220062336A1

公开(公告)日：2022-03-03

申请号：US17412127

申请日：2021-08-25

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Brett Morrison

IPC分类号： A61K35/15 ,  C07K14/47 ,  A61P25/00

摘要： Provided herein are methods and compositions for increasing nerve regeneration activity of a macrophage, and for inducing and accelerating nerve regeneration of an injured or damaged nerve. Methods and compositions provided herein include upregulating the expression of an MCT1 gene in a macrophage.

公开(公告)号：US20220031743A1

公开(公告)日：2022-02-03

申请号：US17275983

申请日：2019-09-13

申请人： LUCA Science Inc.

发明人： Masashi SUGANUMA ,  Hideyoshi HARASHIMA ,  Yuma YAMADA ,  Daisuke SASAKI ,  Takafumi YOKOTA

IPC分类号： A61K35/17 ,  A61K35/15 ,  A61K35/34

摘要： Provided herein are a method for isolation and transplantation of intact mitochondria to a lymphoid organ (a primary lymphoid tissue or a secondary lymphoid tissue), a composition of cells prepared by using a method described herein, and a method for manufacturing cells described herein. In particular, provided herein are methods of isolating intact mitochondria from a donor cell. Also provided herein are methods of transplanting mitochondria into a recipient cell. In some aspects, the methods can be performed in vivo. Further provided are a composition of cells that include the cells prepared using the methods of the present invention.

公开(公告)号：US20220002675A1

公开(公告)日：2022-01-06

申请号：US17477486

申请日：2021-09-16

申请人： Carisma Therapeutics Inc.

发明人： Michael Klichinsky ,  Nicholas G. Minutolo ,  Nicholas R. Anderson

IPC分类号： C12N5/0786 ,  C12N15/86 ,  C07K16/28 ,  C07K14/705 ,  C07K14/725 ,  A61K35/15 ,  C07K16/32 ,  C07K14/735 ,  A61P35/00

摘要： The present disclosure pertains to immune cells comprising chimeric antigen receptors (CARs) and methods of using immune cells comprising CARs.

公开(公告)号：US20210371462A1

公开(公告)日：2021-12-02

申请号：US17264277

申请日：2019-08-01

申请人： ONCOTHERAPY SCIENCE, INC.

发明人： SACHIKO YAMASHITA ,  Tetsuro HIKICHI

IPC分类号： C07K7/06 ,  A61K35/17 ,  A61K35/15 ,  C07K14/74 ,  A61P35/00

摘要： The present invention provides CDCA1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic T cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or CTLs. The present invention also provides compositions and pharmaceutical compositions containing them as an active ingredient. Further, the present invention provides methods of treating and/or preventing cancer, and/or preventing postoperative recurrence thereof, using the peptides, polynucleotides, antigen-presenting cells, cytotoxic T cells or pharmaceutical compositions of the present invention. Methods of inducing an immune response against cancer are also provided.

公开(公告)号：US20210353674A1

公开(公告)日：2021-11-18

申请号：US17443656

申请日：2021-07-27

申请人： Amphera B.V.

发明人： Joachim AERTS ,  Floris DAMMEIJER

IPC分类号： A61K35/15 ,  C12N1/06 ,  A61K45/06 ,  A61P35/00 ,  A61K39/00

摘要： The present invention relates to a tumour lysate and a pharmaceutical composition for use in the treatment of pancreatic cancer. In one aspect, the invention relates to pharmaceutical composition comprising dendritic cells, loaded with said lysate. In one aspect, the pharmaceutical composition is for use in the treatment of pancreatic cancer.

公开(公告)号：US20210353673A1

公开(公告)日：2021-11-18

申请号：US17284449

申请日：2019-10-11

申请人： ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG

发明人： VENKATRAM PRASAD SHASTRI ,  MELIKA SAREM

IPC分类号： A61K35/15 ,  C12N5/0786 ,  C12N5/0787 ,  A61K47/36 ,  G01N33/50

摘要： The present invention relates to isolated mammalian CD11b+/PIEZO-1+ macrophage cells, neutrophil cells, and/or an isolated exosome as secreted by said cells, pharmaceutical compositions comprising said cells and/or exosomes, as well as uses thereof.

公开(公告)号：US20210346479A1

公开(公告)日：2021-11-11

申请号：US17239097

申请日：2021-04-23

申请人： DCPRIME B.V.

发明人： Sandra Van Wetering ,  Adriana Kruisbeek

IPC分类号： A61K39/00 ,  C12N5/0784 ,  A61K35/15

摘要： The invention is in the field of medical sciences. It provides means and methods for the treatment of cancer. More in particular, it provides cells and cell lines that can be developed into fully functional dendritic cells. These cells endogenously express cancer-specific antigens, which makes them particularly suited for the treatment of different kinds of cancer. More in particular, the invention relates to a precursor cell line for dendritic cells called DC-One as deposited at the DSMZ under accession number DSMZ ACC3189 on Nov. 15, 2012.

公开(公告)号：US20210346308A1

公开(公告)日：2021-11-11

申请号：US17278272

申请日：2019-12-17

申请人： GI CELL, INC.

发明人： Won Jong KIM ,  Dong Hyun JANG

IPC分类号： A61K9/51 ,  C08G81/02 ,  A61K35/17 ,  A61K35/15 ,  A61K47/34 ,  A61K31/704 ,  A61P35/00

摘要： The present invention relates to a block copolymer, comprising a hydrophilic first block, a hydrophobic second block, and a functional group capable of specifically binding to thiol.

公开(公告)号：US20210339252A1

公开(公告)日：2021-11-04

申请号：US17367619

申请日：2021-07-05

申请人： Indee. Pty. Ltd.

发明人： Ryan Pawell ,  Amy Twite ,  Geoff Facer ,  Katherine Lau ,  Adrian Lievano ,  Julyana Acevedo

IPC分类号： B01L3/00 ,  A61K35/15 ,  A61K35/17 ,  C12N15/90 ,  C12N13/00 ,  C12N15/64 ,  C12N15/87

摘要： A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.

公开(公告)号：US11154571B2

公开(公告)日：2021-10-26

申请号：US15507838

申请日：2015-04-30

申请人： Jiangsu University

发明人： Shengjun Wang ,  Yungang Wang ,  Jie Tian ,  Ke Rui ,  Jie Ma ,  Bin Ma ,  Xinyi Tang ,  Huaxi Xu

IPC分类号： A61K35/15 ,  C12N5/09 ,  C12N5/0783

摘要： Provided are exosomes sourced from a granulocyte myeloid-derived suppressor cell and an application thereof. The exosomes are named as G-MDSC exo. Also provided is a use of the exosomes in preparing a drug used for suppressing autoimmune diseases. The G-MDSC exo can effectively suppress proliferation of CD4+T cells in vitro, promote induced proliferation of T regulatory (Treg) cells, alleviate foot swelling of model mice having delayed-type hypersensitivity, and suppress attacks of inflammatory bowel disease (IBD) and collagen-induced arthritis (CIA) of the mice.