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公开(公告)号：US20220031743A1
公开(公告)日：2022-02-03
申请号：US17275983
申请日：2019-09-13
申请人： LUCA Science Inc.
摘要： Provided herein are a method for isolation and transplantation of intact mitochondria to a lymphoid organ (a primary lymphoid tissue or a secondary lymphoid tissue), a composition of cells prepared by using a method described herein, and a method for manufacturing cells described herein. In particular, provided herein are methods of isolating intact mitochondria from a donor cell. Also provided herein are methods of transplanting mitochondria into a recipient cell. In some aspects, the methods can be performed in vivo. Further provided are a composition of cells that include the cells prepared using the methods of the present invention.
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公开(公告)号：US20230043700A1
公开(公告)日：2023-02-09
申请号：US17789401
申请日：2020-12-25
申请人： LUCA SCIENCE INC.
发明人： Masashi SUGANUMA , Yuma YAMADA , Hideyoshi HARASHIMA , Daisuke SASAKI , Mitsue HIBINO , Yoshihiro OHTA
IPC分类号： A61K9/127 , A61K35/12 , C12Q1/6883 , A61P43/00
摘要： According to the present invention, there is provided a composition comprising a population of mitochondria with a smaller size and a population of lipid membrane-based vesicles encapsulating mitochondria in a closed space and a method for producing the composition.
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公开(公告)号：US20220267714A1
公开(公告)日：2022-08-25
申请号：US17628834
申请日：2020-07-22
申请人： LUCA SCIENCE INC.
摘要： The present disclosure relates to methods of obtaining mitochondria from cells, mitochondria obtained by such methods, and uses of mitochondria obtained by such methods.
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