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公开(公告)号：US20230102547A1
公开(公告)日：2023-03-30
申请号：US17739037
申请日：2022-05-06
发明人： Yair Alster , Eugene de Juan, JR. , Cary J. Reich , Stephen Boyd , David Sierra , Jose D. Alejandro , K. Angela Macfarlane , Douglas Sutton
IPC分类号： A61F9/00 , A61K9/00 , A61K31/19 , A61K31/407 , A61K31/4178 , A61K31/5377 , A61K31/5415 , A61K31/43 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/56 , A61K31/568 , A61K31/573 , A61K31/58 , A61K31/7036 , A61K38/00 , A61M31/00 , A61K31/335
摘要： A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.
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公开(公告)号：US11607390B2
公开(公告)日：2023-03-21
申请号：US16691579
申请日：2019-11-21
申请人： Massachusetts Institute of Technology , Novo Nordisk A/S , The Brigham and Women's Hospital, Inc.
发明人： Alex G. Abramson , Morten Revsgaard Frederiksen , Brian Jensen , Mikkel Oliver Jespersen , Carlo Giovanni Traverso
IPC分类号： A61K9/48 , A61K9/00 , A61M5/142 , A61M37/00 , A61N1/36 , A61M31/00 , A61M5/158 , A61J3/07 , A61B5/145 , A61B10/02 , A61N1/32 , A61M5/20 , A61M5/32 , A61K38/28 , A61N1/05
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.
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公开(公告)号：US11596778B2
公开(公告)日：2023-03-07
申请号：US17052846
申请日：2020-04-23
发明人： Sung Tae Yoon
摘要： The present disclosure relates to an insertion type drug injection device capable of being inserted into a body for injecting a drug into a skin, including: a main body having an open insert part and formed in a tubular shape having a hollow space therein, a needle assembly formed in the insert part, provided with a plurality of needles, and including a pneumatic port and a drug injection port, and a drug injection pipe inserted into the main body and connected to a drug injection port of the needle assembly, and an air flowing pipe connected to the pneumatic port.
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公开(公告)号：US20230069775A1
公开(公告)日：2023-03-02
申请号：US17984046
申请日：2022-11-09
摘要： A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
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公开(公告)号：US20230061352A1
公开(公告)日：2023-03-02
申请号：US17796348
申请日：2021-01-29
IPC分类号： A61M31/00 , A61K9/00 , A61K31/722 , A61K31/765
摘要： A layered drug delivery device which includes a polymeric tissue interface layer and a polymeric backing layer. The polymeric tissue interface layer includes at least one ther-apeutic agent.
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公开(公告)号：US11590329B2
公开(公告)日：2023-02-28
申请号：US16414212
申请日：2019-05-16
申请人： Spirox, Inc.
发明人： Gene Michal , Daniel L. Cox , Piyush Arora , Michael S. Mirizzi , Scott Baron
IPC分类号： A61M31/00
摘要： In another example, a bioresorbable implant for use in a nasal region includes one or more bioresorbable polymers, and a pharmaceutical composition coupled to the one or more bioresorbable polymers. A release rate of the pharmaceutical composition is related to a degradation rate of the one or more bioresorbable polymers.
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公开(公告)号：US11590072B2
公开(公告)日：2023-02-28
申请号：US16879984
申请日：2020-05-21
摘要： An implantable device comprising a nanochanneled membrane is described. The device uses nanofluidics to control the delivery of diagnostic and/or therapeutic agents intratumorally. The devices can be used for chemotherapy, radiosensitization, immunomodulation, and imaging contrast.
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公开(公告)号：US11589899B2
公开(公告)日：2023-02-28
申请号：US16535506
申请日：2019-08-08
申请人： InnoMed One, LLC
摘要： The disclosed artificial insemination system comprises a cervical plug, catheter, and positioning tool. The cervical plug comprises a shield configured to cover an orifice, an arm attached to one side of the shield that is operable to be inserted into the cervical canal, and an insert member on the other side of the shield. A bore disposed within the cervical plug and extending through the insert member, shield, and arm is operable to receive the catheter used to deposit the semen sample. The positioning tool comprises a handle with a stem extending longitudinally therefrom and terminating at a bracket that is operable to receive the insert member and catheter and assist in preventing the cervical plug from becoming dislodged when the catheter is removed. A further object of this invention is the process by which the disclosed system is used to increase the efficacy of artificial insemination.
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公开(公告)号：US20230059281A1
公开(公告)日：2023-02-23
申请号：US17889318
申请日：2022-08-16
申请人： Thomas W. PFENNIG
发明人： Thomas W. PFENNIG
IPC分类号： A61M31/00
摘要： An ear canal medication applicator including a tympanogram ear canal occlusion earpiece operatively connected to a bulb insufflator through a body, and a syringe operatively connected to an IV line, wherein the syringe is operatively attached to the body and the IV line is threaded through a portion of the tympanogram ear canal occlusion earpiece. A method of treating the ear canal, by providing a dual application of medication at two different locations in the ear canal of an individual and treating the ear canal.
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公开(公告)号：US20230053966A1
公开(公告)日：2023-02-23
申请号：US17795420
申请日：2021-01-27
申请人： Celero Systems, Inc.
发明人： Benjamin D. Pless , Daniel Bacher
摘要： An ingestible medical device that includes an ingestible capsule. Within the ingestible capsule is a non-refillable drug dispenser containing a therapeutic agent. The capsule can also include a real-time clock. A controller within the capsule can be operatively connected to the drug dispenser and can include a memory module and a processor operable to execute a software application stored on the memory module to control the operation of the drug dispenser to administer the therapeutic agent according to a real-time schedule measured via the real-time clock. The ingestible medical device can also include an iontophoretic circuit or system for drug delivery as well as physiological sensors to detect the occurrence or worsening of a medical condition.
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