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    WIRELESS SETUP AND SECURITY OF A CONTINUOUS ANALYTE SENSOR SYSTEM DEPLOYED IN HEALTHCARE INFRASTRUCTURE
    81.
    发明申请
    WIRELESS SETUP AND SECURITY OF A CONTINUOUS ANALYTE SENSOR SYSTEM DEPLOYED IN HEALTHCARE INFRASTRUCTURE 有权

    公开(公告)号：US20230133145A1

    公开(公告)日：2023-05-04

    申请号：US18048818

    申请日：2022-10-21

    Applicant: Dexcom, Inc.

    Inventor： Aniel ALVAREZ ,  Jorge R. BARRERAS ,  Reinier SANCHEZ BAO ,  Barry Nicholas SOLOMON ,  Victor VILLAVERDE GARCIA

    IPC: H04W12/069 ,  A61B5/00 ,  H04W12/03

    Abstract: Techniques and protocols for facilitating wired or wireless secure communications between a sensor system and one or more other devices deployed in healthcare facilities are disclosed. In certain embodiments, the techniques and protocols include secure device pairing techniques and protocols for achieving heightened security, for example, recommended in healthcare facilities. In certain embodiments, a method comprises executing, at an application layer of a sensor system, a password authenticated key exchange (PAKE) protocol with a display device to derive an authentication key; executing, at the sensor system, an authenticated pairing protocol with the display device; after the authenticating is successful, establishing an encrypted connection between the sensor system and the display device; and transmitting, from the sensor system to the display device, analyte data indicative of measured analyte levels via the encrypted connection.

    Retrospective retrofitting method to generate a continuous glucose concentration profile by exploiting continuous glucose monitoring sensor data and blood glucose measurements
    84.
    发明授权
    Retrospective retrofitting method to generate a continuous glucose concentration profile by exploiting continuous glucose monitoring sensor data and blood glucose measurements 有权

    公开(公告)号：US11633156B2

    公开(公告)日：2023-04-25

    申请号：US16373454

    申请日：2019-04-02

    Applicant: DexCom, Inc.

    Inventor： Claudio Cobelli ,  Simone Del Favero ,  Andrea Facchinetti ,  Giovanni Sparacino

    IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1495 ,  G16H50/30 ,  G16H50/20

    Abstract: Continuous Glucose Monitoring (CGM) devices provide glucose concentration measurements in the subcutaneous tissue with limited accuracy and precision. Therefore, CGM readings cannot be incorporated in a straightforward manner in outcome metrics of clinical trials e.g. aimed to assess new glycaemic-regulation therapies. To define those outcome metrics, frequent Blood Glucose (BG) reference measurements are still needed, with consequent relevant difficulties in outpatient settings. Here we propose a “retrofitting” algorithm that produces a quasi continuous time BG profile by simultaneously exploiting the high accuracy of available BG references (possibly very sparsely collected) and the high temporal resolution of CGM data (usually noisy and affected by significant bias). The inputs of the algorithm are: a CGM time series; some reference BG measurements; a model of blood to interstitial glucose kinetics; and a model of the deterioration in time of sensor accuracy, together with (if available) a priori information (e.g. probabilistic distribution) on the parameters of the model. The algorithm first checks for the presence of possible artifacts or outliers on both CGM datastream and BG references, and then rescales the CGM time series by exploiting a retrospective calibration approach based on a regularized deconvolution method subject to the constraint of returning a profile laying within the confidence interval of the reference BG measurements. As output, the retrofitting algorithm produces an improved “retrofitted” quasi-continuous glucose concentration signal that is better (in terms of both accuracy and precision) than the CGM trace originally measured by the sensor. In clinical trials, the so-obtained retrofitted traces can be used to calculate solid outcome measures, avoiding the need of increasing the data collection burden at the patient level.

    CONTINUOUS ANALYTE MONITOR DATA RECORDING DEVICE OPERABLE IN A BLINDED MODE
    86.
    发明申请
    CONTINUOUS ANALYTE MONITOR DATA RECORDING DEVICE OPERABLE IN A BLINDED MODE 有权

    公开(公告)号：US20230074617A1

    公开(公告)日：2023-03-09

    申请号：US18050365

    申请日：2022-10-27

    Applicant: Dexcom, Inc.

    Inventor： Jorge VALDES ,  David PRICE ,  Leif N. BOWMAN ,  Kristin Koenekamp COTE

    IPC: A61B5/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/155 ,  A61B5/157 ,  G16H40/67 ,  A61B5/145 ,  A61B5/1486

    Abstract: A system is provided for monitoring analyte in a host, including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. In one embodiment, the device includes a single point analyte monitor, from which it obtains an analyte value, and is configured to display only single point analyte measurement values, and not any analyte measurement values associated with data received from the continuous analyte sensor. Instead, data received from the continuous analyte sensor is used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement. In another embodiment, the device provides for toggling between two modes, with one mode that allows for display of glucose concentration values associated with the continuous glucose sensor and a second mode that prevents the display of glucose concentration values associated with the continuous glucose sensor.

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