公开(公告)号：US12132303B2

公开(公告)日：2024-10-29

申请号：US18110509

申请日：2023-02-16

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Shahab Mehraeen ,  Sudipta Sen

IPC分类号： H02H3/087 ,  G01R31/327 ,  H01H9/54 ,  H01H33/59 ,  H02H1/06 ,  H02H3/02 ,  H02H9/02 ,  H03K17/13

CPC分类号： H02H3/087 ,  G01R31/3272 ,  H01H9/54 ,  H01H33/596 ,  H02H1/063 ,  H02H3/021 ,  H02H9/02 ,  H03K17/13

摘要： The present disclosure provides a DC mechanical circuit breaker that can utilize two switches, one of which can generate zero-crossing with an alternate oscillatory circuit for the other one, which can be a conventional zero-crossing-based AC breaker and can be used in the main circuit. This is different from the conventional single-switch commute-and-absorb method currently used. The present disclosure shows that disclosed circuit breaker improves the fault current extinction and significantly reduces the voltage rate-of-change while creating the current zero-crossing faster compared to the available technology. Thus, disclosed circuit breaker is capable of interrupting high DC currents with minimal arc through a less expensive AC circuit breaker. Simulation and hardware results are provided to show the efficiency of the disclosed circuit breaker.

公开(公告)号：US12121518B2

公开(公告)日：2024-10-22

申请号：US16742625

申请日：2020-01-14

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Hamid Boulares ,  Mohamed Ghonim

IPC分类号： A61K31/502 ,  A61K31/573 ,  A61K38/00 ,  A61P35/00 ,  C07K16/28

CPC分类号： A61K31/502 ,  A61K31/573 ,  A61P35/00 ,  C07K16/2827 ,  A61K38/00

摘要： The invention is directed to roles for low doses of PARP-1 inhibitors and synergistic combinations thereof to treat disease.

公开(公告)号：US20240316166A1

公开(公告)日：2024-09-26

申请号：US18368505

申请日：2023-09-14

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Hong Xin

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K14/40

CPC分类号： A61K39/0002 ,  A61K39/39575 ,  C07K14/40 ,  A61K2039/505 ,  A61K2039/55505 ,  A61K2039/575 ,  C07K2317/24 ,  C07K2319/40

摘要： This invention is directed to vaccine compositions and methods of using the same to prevent infection.

公开(公告)号：US12023454B2

公开(公告)日：2024-07-02

申请号：US17285131

申请日：2019-10-14

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Jacob Bursavich ,  Benjamin Seago ,  Logan Daigle

IPC分类号： A61M25/06 ,  A61M25/09

CPC分类号： A61M25/06 ,  A61M25/09 ,  A61M2205/8281

摘要： A device and method are disclosed for intravenous cannulation. The device employs a spring to precisely and accurately control the force and velocity imparted to a piercing needle, with mechanical constraints built into the device to precisely and accurately control the distance through which the piercing needle travels. A sheathed-needle configuration is used with an outer, echogenic needle that can be seen via ultrasound; and an inner needle used to pierce the vein. The operator releases the piercing needle with a controlled velocity, controlled force, and controlled travel distance. The device reduces the human error and complications that have previously been associated with manually piercing a vein for cannulation.

公开(公告)号：US20240180895A1

公开(公告)日：2024-06-06

申请号：US18282173

申请日：2022-03-21

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Jacob Meariman ,  Daniel R. Kapusta ,  Juan Gao

IPC分类号： A61K31/485 ,  A61K31/4965 ,  A61K31/5415 ,  A61K31/635 ,  A61K38/07 ,  A61P9/12 ,  A61P13/12

CPC分类号： A61K31/485 ,  A61K31/4965 ,  A61K31/5415 ,  A61K31/635 ,  A61K38/07 ,  A61P9/12 ,  A61P13/12

摘要： A method of method of preventing or reversing diuretic resistance, the method comprising administering to the subject an amount of a kappa opioid receptor agonist (KOA) sufficient to selectively increase urine output, wherein the KOA decreases or does not change urinary excretion of electrolytes.

公开(公告)号：US20240128741A1

公开(公告)日：2024-04-18

申请号：US18482609

申请日：2023-10-06

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Shahab Mehraeen ,  Sudipta Sen

IPC分类号： H02H7/26

CPC分类号： H02H7/268

摘要： An embodiment of a DC circuit breaker system includes a first mechanical switch, a first parallel capacitor connecting a first terminal and a second terminal of the first mechanical switch, a second mechanical switch in series with the first mechanical switch, a second parallel capacitor connecting a first terminal and a second terminal of the second mechanical switch, a first diode connecting the first terminal and the second terminal; and a second diode connecting the first terminal and the second terminal. According to the present disclosure, the first mechanical switch initiates a separation of contacts in response to a fault current; the second mechanical switch initiates a separation of contacts in response to the fault current; and opening of the first and second mechanical switches and turning off of the first and second diodes reverse a direction of a current flow and clear a current fault.

公开(公告)号：US11953501B2

公开(公告)日：2024-04-09

申请号：US17428416

申请日：2020-02-04

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Sunyoung Kim

IPC分类号： G01N33/53 ,  G01N33/573

CPC分类号： G01N33/573 ,  G01N2333/916 ,  G01N2800/065 ,  G01N2800/52

摘要： This invention comprises compositions and methods to determine the prognosis of necrotizing enterocolitis.

公开(公告)号：US11944650B2

公开(公告)日：2024-04-02

申请号：US16833099

申请日：2020-03-27

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Frank Ho Pak Lau ,  Ian Hodgdon ,  Michael Cook

IPC分类号： A61K35/50 ,  A61B17/00 ,  A61F2/00 ,  A61K9/00 ,  A61L27/24 ,  A61L27/36 ,  A61L31/00 ,  A61L31/16 ,  A61P41/00

CPC分类号： A61K35/50 ,  A61F2/0063 ,  A61K9/0024 ,  A61L27/24 ,  A61L27/362 ,  A61L31/005 ,  A61L31/16 ,  A61P41/00 ,  A61B2017/00238 ,  A61F2002/0072 ,  A61F2220/0016 ,  A61L2430/34

摘要： A method of preventing or reducing the occurrence and/or development of a hernia within a subject at risk of developing a hernia includes implanting a graft material in contact with an opening in an abdominal wall. The graft material promotes healing of the abdominal wall and includes placental or placental derived tissue.

公开(公告)号：US20240077498A1

公开(公告)日：2024-03-07

申请号：US17326309

申请日：2021-05-20

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Diana CRUZ-TOPETE ,  Adrian CHAPA-RODRIGUEZ ,  Hrishikesh V. SAMANT ,  Oscar GOMEZ-TORRES ,  Johnathan Steven ALEXANDER

IPC分类号： G01N33/68 ,  A61P1/16 ,  C07K16/28 ,  C12N15/11

CPC分类号： G01N33/6893 ,  A61P1/16 ,  C07K16/2803 ,  C12N15/11 ,  A61K2039/505 ,  G01N2333/70507 ,  G01N2800/085

摘要： Therapeutics and methods of diagnosing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a patient comprising obtaining a sample from the patient, determining a level of a signaling lymphocytic activation molecule 1 (SLAMF1) in the sample from the patient, and diagnosing the patient with NAFLD when the level of the SLAMF1 is at least an elevated threshold level for the SLAMF1. Therapeutics and methods of treating non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a patient in need of treatment comprising administering a pharmaceutically effective dose of a therapeutic, wherein the therapeutic includes a signaling lymphocytic activation molecule 1 (SLAMF1) antagonist.

公开(公告)号：US11911751B2

公开(公告)日：2024-02-27

申请号：US18089365

申请日：2022-12-27

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： George Geoffrey Stanley ,  Drew Michael Hood

IPC分类号： B01J31/24

CPC分类号： B01J31/2409 ,  B01J2231/321 ,  B01J2531/0216 ,  B01J2531/845

摘要： Disclosed are highly active cationic cobalt phosphine complexes, both mono- and bimetallic, that can catalyze hydroformylation reactions. The disclosed catalysts can be utilized in methods that provide reaction processes that are hundreds of times faster than high pressure HCo(CO)4 or phosphine-modified HCo(CO)3(PR3) catalysts and operate at considerably lower pressures and temperatures. Also disclosed are methods of hydroformylation using the described transition metal complexes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.