公开(公告)号：US20050119349A1

公开(公告)日：2005-06-02

申请号：US10972773

申请日：2004-10-26

Applicant: Helmut Buschmann ,  Wolfgang Hell ,  Markus Kegel

Inventor： Helmut Buschmann ,  Wolfgang Hell ,  Markus Kegel

IPC: A61K31/137 ,  C07B39/00 ,  C07C20060101 ,  C07C17/16 ,  C07C19/08 ,  C07C211/26 ,  C07C213/08 ,  C07C217/54 ,  C07C217/74

CPC classification number: C07B39/00 ,  C07B2200/07 ,  C07C17/16 ,  C07C213/08 ,  C07C2601/14 ,  C07C217/74

Abstract: The present invention relates to a process for converting a tertiary OH group of an organic compound into a tertiary Cl group of the organic compound by using a solvent selected from the group comprising toluene, o-xylene, m-xylene, p-xylene and mixtures thereof, and thionyl chloride as the chlorinating agent.

Abstract translation: 本发明涉及通过使用选自甲苯，邻二甲苯，间二甲苯，对二甲苯和混合物的溶剂将有机化合物的叔OH基转化为有机化合物的叔C1的方法 和亚硫酰氯作为氯化剂。

公开(公告)号：US06656937B2

公开(公告)日：2003-12-02

申请号：US10198073

申请日：2002-07-19

Applicant: Tieno Germann ,  Stefanie Frosch ,  Erik Wade ,  Helmut Buschmann ,  Oswald Zimmer

Inventor： Tieno Germann ,  Stefanie Frosch ,  Erik Wade ,  Helmut Buschmann ,  Oswald Zimmer

IPC: A61K315355

CPC classification number: C07D211/92 ,  C07D211/88

Abstract: Substituted glutarimides of formula I and their method of making. Also disclosed are pharmaceutical compositions comprising the glutarimidie, particularly as immunomodulators and as inhibitors of angiopathies, or haematological or oncological diseases, as well as a method for treating various diseases using the glutarimides.

Abstract translation: 式I的取代戊二酰亚胺及其制备方法。 还公开了包含戊二酰亚胺的药物组合物，特别是作为免疫调节剂和血管病，血液病或肿瘤学疾病的抑制剂以及使用戊二酰胺治疗各种疾病的方法。

公开(公告)号：US06653508B2

公开(公告)日：2003-11-25

申请号：US10046567

申请日：2002-01-16

Applicant: Michael Sattlegger ,  Helmut Buschmann ,  Babette-Yvonne Koegel

Inventor： Michael Sattlegger ,  Helmut Buschmann ,  Babette-Yvonne Koegel

IPC: C07C22500

CPC classification number: C07C323/32 ,  C07C215/30 ,  C07C215/54 ,  C07C215/62 ,  C07C217/56 ,  C07C217/66 ,  C07C225/16 ,  C07C2603/26 ,  C07F9/4021

Abstract: Substituted 3-amino-2-benzyl-1-phenlypropane derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat various medical conditions.

Abstract translation: 取代的3-氨基-2-苄基-1-苯基丙烷衍生物，其制备方法，含有它们的药物组合物，及其用于治疗各种医疗条件的方法。

公开(公告)号：US06476044B1

公开(公告)日：2002-11-05

申请号：US10076109

申请日：2002-02-15

Applicant: Stephan Wnendt ,  Wolfgang Strassburger ,  Helmut Buschmann ,  Elke Reiss-Mueller ,  Thomas Krueger

Inventor： Stephan Wnendt ,  Wolfgang Strassburger ,  Helmut Buschmann ,  Elke Reiss-Mueller ,  Thomas Krueger

IPC: A61K3144

CPC classification number: A61K31/485

Abstract: A method for agonizing or antagonizing the ORL1 (opioid receptor-like) receptor of the nociceptin/orphanin FQ ligand ORL1 receptor system using a morphinan compound of the general formula I or derivatives thereof. Also disclosed are methods for treating neuropathic pain and/or anxiolysis and/or depression and/or diuresis and/or urinary incontinence and/or hypotension and or hypertension and/or senile dementia and/or Alzheimer's disease and/or general cognitive disfunctions an/or tinnitus and/or impaired hearing and/or epilepsy and/or obesity and/or cachexia.

Abstract translation: 使用通式I的吗啡喃化合物或其衍生物来激动或拮抗伤害感受肽/孤儿素FQ配体ORL1受体系统的ORL1（阿片受体样受体）受体的方法。 还公开了治疗神经性疼痛和/或抗焦虑和/或抑郁和/或利尿和/或尿失禁和/或低血压和/或高血压和/或老年痴呆和/或阿尔茨海默氏病和/或一般认知障碍的方法， 或耳鸣和/或受损的听力和/或癫痫和/或肥胖和/或恶病质。

公开(公告)号：US5728885A

公开(公告)日：1998-03-17

申请号：US784078

申请日：1997-01-17

Applicant: Helmut Buschmann ,  Werner Winter ,  Ivars Graudums ,  Peter Jansen, deceased ,  Wolfgang Werner Alfred Strassburger ,  Elmar Josef Friederichs

Inventor： Helmut Buschmann ,  Werner Winter ,  Ivars Graudums ,  Peter Jansen, deceased ,  Wolfgang Werner Alfred Strassburger ,  Elmar Josef Friederichs

IPC: A61K31/135 ,  A61P25/04 ,  C07B57/00 ,  C07C213/00 ,  C07C213/08 ,  C07C213/10 ,  C07C215/64 ,  C07C217/74 ,  C07C209/88

CPC classification number: C07C213/10 ,  C07C213/08 ,  C07C2101/14

Abstract: A method of preparing the enantiomers of O-demethyltramadol and the use of the enantiomers as pain-killing drugs are described.

Abstract translation: 描述了制备O-去甲基曲马多的对映体和使用对映体作为止痛药的方法。