公开(公告)号：US09814232B2

公开(公告)日：2017-11-14

申请号：US15026855

申请日：2015-02-12

Applicant: NISSHA PRINTING CO., LTD. ,  NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY

Inventor： Tetsuya Nakayama ,  Yasuisa Takinishi ,  Yoshihide Inako ,  Hajime Mori ,  Tomoko Hirano ,  Yoshihiro Harada

IPC: A01N25/34 ,  A01M1/20 ,  A01N63/02

CPC classification number: A01N25/34 ,  A01M1/2016 ,  A01M1/2055 ,  A01N63/02 ,  A01N25/10

Abstract: An insect control sheet containing a Cry polyhedron prepared by fixing an insecticidal protein (a Cry toxin) produced by Bacillus thuringiensis to a polyhedron of polyhedrin protein is provided. The insect control sheet contains the Cry polyhedron and is used by floating on water. The insect control sheet is floatable on water, and includes a pure matrix layer 20 and a toxin-containing matrix layer 30 containing the Cry polyhedron 51 which are layered on the underside of a sheet-shaped first sheet substrate 10. The pure matrix layer 20 is composed of a degradable or water-soluble second material and the toxin-containing matrix layer 30 is composed of a degradable or water-soluble third material and the Cry polyhedron. The toxin-containing matrix layer sustainably releases the Cry polyhedron to the water on which the insect control sheet is floated.

公开(公告)号：US09527955B2

公开(公告)日：2016-12-27

申请号：US14783640

申请日：2014-03-19

Applicant: NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY

Inventor： Atsushi Abiko ,  Yasumi Maruta

IPC: C08G63/08 ,  C08G63/82 ,  C08G63/664 ,  C08G18/42

CPC classification number: C08G63/823 ,  C08G18/4277 ,  C08G18/428 ,  C08G63/08 ,  C08G63/664

Abstract: This invention provides a novel method for producing a lactide-lactone copolymer. The method is characterized by copolymerizing a lactide and a lactone using a molybdenum compound as a catalyst.

Abstract translation: 本发明提供了一种制备丙交酯 - 内酯共聚物的新方法。 该方法的特征在于使用钼化合物作为催化剂共聚丙交酯和内酯。

公开(公告)号：US20150376297A1

公开(公告)日：2015-12-31

申请号：US14767373

申请日：2014-02-03

Applicant: NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY

Inventor： Yoichi Kumada ,  Yasuyuki Ishikawa ,  Yusuke Fujiwara ,  Michimasa Kishimoto

IPC: C07K16/42 ,  C07K16/40 ,  C08F122/10 ,  C07K16/26 ,  C07K17/08 ,  C07K16/30 ,  C07K16/18

CPC classification number: C07K16/4241 ,  C07K16/065 ,  C07K16/18 ,  C07K16/26 ,  C07K16/3007 ,  C07K16/40 ,  C07K17/08 ,  C07K2317/14 ,  C07K2317/40 ,  C07K2317/622 ,  C07K2319/35 ,  C08F122/10

Abstract: A method for refolding an antibody, a process for producing a refolded antibody, a refolded antibody, and uses thereof are provided. A method for refolding an antibody in a liquid phase comprises the steps of denaturing an inactive antibody binding directly or through a linker to a peptide, the peptide having an isoelectric point lower than the isoelectric point of the inactive antibody, and dispersing in a liquid phase the peptide-binding inactive antibody denatured in the step above. Also provided is a process for producing a refolded antibody.

Abstract translation: 提供了重折叠抗体的方法，重折叠抗体的制备方法，重折叠抗体及其用途。 用于在液相中重新折叠抗体的方法包括使直接结合或通过接头结合到肽的无活性抗体变性的步骤，所述肽具有低于无活性抗体的等电点的等电点，并分散在液相中 在上述步骤中变性的肽结合的无活性抗体。 还提供了生产重折叠抗体的方法。

公开(公告)号：US20150219574A1

公开(公告)日：2015-08-06

申请号：US14420094

申请日：2013-08-07

Applicant: NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY

Inventor： Haruhiko Yao

IPC: G01N25/20 ,  G01K7/01 ,  G01K17/08

CPC classification number: G01K17/04 ,  G01N25/482 ,  H01L35/32

Abstract: There is provided a calorimeter. Heat flows in and out of the sample via a thermoelectric module. The thermoelectric module is so constituted that a pair of a P-type thermoelectric element and an N-type thermoelectric element is disposed between substrates, and the pair of the thermoelectric elements are connected in n pairs so that the P-type thermoelectric elements and the N-type thermoelectric element are arranged alternately in π-shape; a calorimetric sensitivity of the thermoelectric module of a thermal conductance surrounding thermoelectric module and a thermal conductance between substrates of the thermoelectric modules and a noise based on an electric resistance of the thermoelectric module depend on an L/A ratio of the thermoelectric element constituting the thermoelectric module and the number n of the pairs of the thermoelectric elements, where the L/A ratio is 6 mm−1 or more, and the number n of the pairs is 4 or more.

Abstract translation: 提供量热计。 热量通过热电模块进出样品。 该热电模块构成为在基板之间设置一对P型热电元件和N型热电元件，并且一对热电元件​​以n对方式连接，使得P型热电元件和 N型热电元件交替排列成型; 热电模块周围的热电模块的热量模块的热量敏感性和热电模块的基板之间的热传导和基于热电模块的电阻的噪声取决于构成热电模块的热电元件的L / A比 模块和L / A比为6mm-1以上的热电元件对的数量n，并且对的数量n为4以上。

公开(公告)号：US20150038675A1

公开(公告)日：2015-02-05

申请号：US14378433

申请日：2013-02-12

Applicant: National University Corporation Kyoto Institute of Technology

Inventor： Yoichi Kumada ,  Michimasa Kishimoto ,  Takeru Otsuka

IPC: C07K17/14 ,  C07K7/08 ,  C07K7/06 ,  C07K14/245

CPC classification number: C07K17/14 ,  C07K7/06 ,  C07K7/08 ,  C07K14/245 ,  C07K2319/00 ,  C07K2319/23 ,  C12N9/0006 ,  C12N11/14

Abstract: The purpose of the present invention is to provide: a peptide having an affinity for silicon nitride; a polynucleotide encoding the peptide; an expression vector for expressing the peptide having an affinity for silicon nitride; an expression vector for expressing a peptide fusion protein that comprises the peptide having an affinity for silicon nitride and a target protein; a transformant obtained by introducing the expression vector into a host cell; a peptide fusion protein obtained from the transformant; a silicon nitride substrate to which a peptide having an affinity for silicon nitride has been bonded; a method for immobilizing a target protein to a silicon nitride substrate; a composition for immobilizing a target protein to a silicon nitride substrate, the composition comprising a peptide having an affinity for silicon nitride; and a linker for immobilizing a target protein to a silicon nitride substrate, the linker comprising a peptide having an affinity for silicon nitride. The invention involves a peptide having an affinity for silicon nitride, the peptide comprising (1-1) a peptide having the amino acid sequence of one of SEQ ID NOS: 1, 2 and 23 to 27, (1-2) a peptide that has an affinity for silicon nitride and comprises an amino acid sequence obtained by deleting, adding, and/or substituting one or more amino acids in one of the amino acid sequences indicated in (1-1), or a fragment of one of the peptides.

Abstract translation: 本发明的目的是提供：对氮化硅具有亲和力的肽; 编码该肽的多核苷酸; 用于表达对氮化硅具有亲和性的肽的表达载体; 用于表达包含对氮化硅和靶蛋白具有亲和力的肽的肽融合蛋白的表达载体; 通过将表达载体导入宿主细胞获得的转化体; 从转化体获得的肽融合蛋白; 已经结合了对氮化硅具有亲和性的肽的氮化硅衬底; 将靶蛋白固定在氮化硅衬底上的方法; 用于将靶蛋白固定到氮化硅衬底的组合物，所述组合物包含对氮化硅具有亲和性的肽; 以及用于将靶蛋白固定到氮化硅衬底的接头，所述接头包含对氮化硅具有亲和性的肽。 本发明涉及对氮化硅具有亲和力的肽，所述肽包含（1-1）具有SEQ ID NO：1,2和23至27之一的氨基酸序列的肽，（1-2）肽， 对氮化硅具有亲和性，并且包含通过在（1-1）所示的氨基酸序列之一中缺失，添加和/或取代一个或多个氨基酸而获得的氨基酸序列，或其中一个肽的一个片段 。