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    DISPOSABLE, IN-LINE ENTEROTOMY DETECTION DEVICE
    82.
    发明申请
    DISPOSABLE, IN-LINE ENTEROTOMY DETECTION DEVICE 审中-公开
    可替代的，在线ENTEROTOMY检测装置

    公开(公告)号：US20160317081A1

    公开(公告)日：2016-11-03

    申请号：US15108124

    申请日：2014-12-29

    申请人： THE METHODIST HOSPITAL

    发明人： Albert Yung-Hsiang Huang

    IPC分类号： A61B5/00 ,  A61B17/34 ,  A61M39/10 ,  A61M13/00

    CPC分类号： A61B5/4836 ,  A61B5/4255 ,  A61B17/3423 ,  A61B17/3474 ,  A61B2010/0083 ,  A61B2017/00022 ,  A61B2017/0023 ,  A61B2090/0807 ,  A61B2562/029 ,  A61M13/003 ,  A61M13/006 ,  A61M39/10 ,  A61M2230/00 ,  G01N21/783 ,  G01N33/497

    摘要： An in-line enterotomy detection device for use in a surgical procedure wherein access to an internal operating field is provided through a plurality of access ports and further wherein a pressurized insufflating gas is delivered to the internal operating field through one access port and vented from the internal operating field through another access port, the in-line enterotomy detection device comprising: a housing having an inlet, an outlet, and a passageway connecting the inlet to the outlet, the inlet being configured for connection to an access port venting gas from the internal operating field and the outlet being configured to vent gas from the in-line enterotomy detection device; and at least one non-electrical colorimetric enteric gas sensor disposed within the passageway for determining at least one of the presence of a selected enteric gas and the concentration of a selected enteric gas and indicating that presence by a visually-apparent change in appearance.

    摘要翻译： 一种用于外科手术的在线肠切除术检测装置，其中通过多个进入口提供对内部操作区域的访问，并且其中，加压吹入气体通过一个进入端口被输送到内部操作区域并从 内部操作区域通过另一个进入端口，该在线肠切除术检测装置包括：壳体，其具有入口，出口和将入口连接到出口的通道，该入口被配置用于连接到通入口， 所述内部操作区域和所述出口构造成从所述在线肠切除术检测装置排出气体; 以及设置在所述通道内的至少一个非电气比重肠溶气体传感器，用于确定选定的肠溶气的存在和所选择的肠溶气的浓度中的至少一种，并通过视觉上明显的外观变化来指示存在。

    MULTIPLEXED VOLUMETRIC BAR CHART CHIP FOR POINT OF CARE BIOMARKER AND ANALYTE QUANTITATION
    83.
    发明申请
    MULTIPLEXED VOLUMETRIC BAR CHART CHIP FOR POINT OF CARE BIOMARKER AND ANALYTE QUANTITATION 审中-公开
    用于生物标记点和分析数量的多重体积条形图

    公开(公告)号：US20160097767A1

    公开(公告)日：2016-04-07

    申请号：US14817258

    申请日：2015-08-04

    申请人： The Methodist Hospital Research Institute

    发明人： Lidong Qin ,  Yujun Song

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54386 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/065 ,  C12Q1/6823 ,  G01N33/54306 ,  G01N33/54366

    摘要： Apparatus for determining the quantity of a target protein and other types of biomarkers or analytes present in a sample, the apparatus comprising: a top plate comprising a plurality of recesses arranged to form a plurality of rows extending parallel to one another; and a bottom plate comprising a plurality of recesses arranged to form a plurality of rows extending parallel to one another, and a plurality of channels extending perpendicularly to the plurality of rows of the bottom plate; wherein the top plate and the bottom plate are assembled together so that the top plate is on top of the bottom plate and the recesses of the top plate communicate with the recesses of the bottom plate so as to form a plurality of rows; and wherein at least one of the top plate and the bottom plate is configured to slide relative to the other of the top plate and the bottom plate in order to form a plurality of columns, with each of the plurality of columns in communication with each of the plurality of channels.

    摘要翻译： 用于确定样品中存在的靶蛋白和其他类型的生物标志物或分析物的量的装置，所述装置包括：顶板，其包括多个凹槽，所述多个凹槽被布置成形成彼此平行延伸的多个行; 以及底板，其包括布置成形成彼此平行延伸的多个行的多个凹槽和垂直于所述底板的多排延伸的多个通道; 其中顶板和底板组装在一起，使得顶板位于底板的顶部，并且顶板的凹部与底板的凹部连通以形成多排; 并且其中所述顶板和所述底板中的至少一个被配置为相对于所述顶板和所述底板中的另一个滑动以形成多个列，所述多个列中的每一个与所述顶板和所述底板中的每一个相连通 多个通道。

    RAPID DETECTION AND QUANTITATION OF PATHOGEN-SPECIFIC BIOMARKERS USING NANOPOROUS DUAL- OR MULTI-LAYER SILICA FILMS
    85.
    发明申请
    RAPID DETECTION AND QUANTITATION OF PATHOGEN-SPECIFIC BIOMARKERS USING NANOPOROUS DUAL- OR MULTI-LAYER SILICA FILMS 审中-公开
    使用纳米双层或多层二氧化硅薄膜快速检测和定量病原特异性生物标志物

    公开(公告)号：US20150260715A1

    公开(公告)日：2015-09-17

    申请号：US14720715

    申请日：2015-05-22

    申请人： The Methodist Hospital Research Institute

    发明人： Ye HU ,  Xin MA ,  Hung-Jen WU ,  Jia FAN ,  Tong SUN

    IPC分类号： G01N33/569 ,  G01N33/552

    CPC分类号： G01N33/5695 ,  G01N33/552 ,  G01N33/569 ,  G01N2333/35 ,  G01N2469/10

    摘要： Improved methods for detecting active tuberculosis are disclosed. A method comprises enriching at least one M. tuberculosis-specific biomolecule from a sample by contacting the sample with a nanoporous film; and detecting the presence of the M. tuberculosis-specific biomolecule or fragment(s) thereof. The method may further comprise digesting the enriched M. tuberculosis-specific biomolecule with an enzyme to produce a digestion product comprising at least one fragment of the M. tuberculosis-specific biomolecule. Improved sensitivity and speed achieved.

    摘要翻译： 公开了用于检测活动性结核病的改进方法。 一种方法包括通过使样品与纳米孔膜接触来从样品中富集至少一种结核分枝杆菌特异性生物分子; 并检测结核分枝杆菌特异性生物分子或其片段的存在。 该方法还可以包括用酶消化富集的结核分枝杆菌特异性生物分子，以产生包含结核分枝杆菌特异性生物分子的至少一个片段的消化产物。 提高灵敏度和速度。

    Multiplexed volumetric bar chart chip for point of care biomarker and analyte quantitation
    87.
    发明授权
    Multiplexed volumetric bar chart chip for point of care biomarker and analyte quantitation 有权
    多重体积条形图芯片，用于护理点生物标志物和分析物定量

    公开(公告)号：US09097710B2

    公开(公告)日：2015-08-04

    申请号：US13834614

    申请日：2013-03-15

    申请人： The Methodist Hospital Research Institute

    发明人： Lidong Qin ,  Yujun Song

    IPC分类号： G01N33/543 ,  C12Q1/68 ,  B01L3/00

    CPC分类号： G01N33/54386 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/065 ,  C12Q1/6823 ,  G01N33/54306 ,  G01N33/54366

    摘要： Apparatus for determining the quantity of a target protein, biomarker or analyte present in a sample, comprising a top plate and a bottom plate, each comprising a plurality of recesses arranged to form a plurality of rows extending parallel to one another, and a plurality of channels extending perpendicularly to the plurality of rows of the bottom plate; wherein the top plate and the bottom plate are assembled together so that the top plate is on top of the bottom plate and the recesses of the top plate communicate with the recesses of the bottom plate so as to form a plurality of rows; and wherein at least one of the top and bottom plate is configured to slide relative to the other of the top and bottom plate in order to form a plurality of columns, with each of the columns in communication with each of the channels.

    摘要翻译： 用于确定样品中存在的目标蛋白质，生物标志物或分析物的量的装置，包括顶板和底板，每个包括多个凹槽，所述多个凹槽布置成形成彼此平行延伸的多个行，以及多个 通道垂直于底板的多排延伸; 其中顶板和底板组装在一起，使得顶板位于底板的顶部，并且顶板的凹部与底板的凹部连通以形成多排; 并且其中所述顶板和底板中的至少一个被配置为相对于所述顶板和底板中的另一个滑动，以便形成多个列，其中每个柱与每个通道连通。

    MULTIPLEXED VOLUMETRIC BAR CHART CHIP FOR POINT OF CARE BIOMARKER AND ANALYTE QUANTITATION
    88.
    发明申请
    MULTIPLEXED VOLUMETRIC BAR CHART CHIP FOR POINT OF CARE BIOMARKER AND ANALYTE QUANTITATION 有权
    用于生物标记点和分析数量的多重体积条形图

    公开(公告)号：US20140106346A1

    公开(公告)日：2014-04-17

    申请号：US13834614

    申请日：2013-03-15

    申请人： The Methodist Hospital Research Institute

    发明人： Lidong Qin ,  Yujun Song

    IPC分类号： G01N33/543 ,  C12Q1/68

    CPC分类号： G01N33/54386 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/065 ,  C12Q1/6823 ,  G01N33/54306 ,  G01N33/54366

    摘要： Apparatus for determining the quantity of a target protein, biomarker or analyte present in a sample, comprising a top plate and a bottom plate, each comprising a plurality of recesses arranged to form a plurality of rows extending parallel to one another, and a plurality of channels extending perpendicularly to the plurality of rows of the bottom plate; wherein the top plate and the bottom plate are assembled together so that the top plate is on top of the bottom plate and the recesses of the top plate communicate with the recesses of the bottom plate so as to form a plurality of rows; and wherein at least one of the top and bottom plate is configured to slide relative to the other of the top and bottom plate in order to form a plurality of columns, with each of the columns in communication with each of the channels.

    摘要翻译： 用于确定样品中存在的目标蛋白质，生物标志物或分析物的量的装置，包括顶板和底板，每个包括多个凹槽，所述多个凹槽布置成形成彼此平行延伸的多个行，以及多个 通道垂直于底板的多排延伸; 其中顶板和底板组装在一起，使得顶板位于底板的顶部，并且顶板的凹部与底板的凹部连通以形成多排; 并且其中所述顶板和底板中的至少一个被配置为相对于所述顶板和底板中的另一个滑动，以便形成多个列，其中每个柱与每个通道连通。

    METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO AN INDIVIDUAL
    89.
    发明申请
    METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO AN INDIVIDUAL 有权

    公开(公告)号：US20230043685A1

    公开(公告)日：2023-02-09

    申请号：US17969523

    申请日：2022-10-19

    申请人： THE METHODIST HOSPITAL ,  CORNELL UNIVESITY

    发明人： Santosh A. Helekar ,  Henning U. Voss

    IPC分类号： A61N2/00 ,  A61B5/00 ,  A61N2/12 ,  A61B5/05 ,  A61B5/245 ,  A61B5/291 ,  A61B5/369 ,  A42B1/04 ,  A42B1/242

    摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

    ELECTROSTATICALLY GATED NANOFLUIDIC MEMBRANES FOR CONTROL OF MOLECULAR TRANSPORT
    90.
    发明申请
    ELECTROSTATICALLY GATED NANOFLUIDIC MEMBRANES FOR CONTROL OF MOLECULAR TRANSPORT 有权

    公开(公告)号：US20230043407A1

    公开(公告)日：2023-02-09

    申请号：US17758644

    申请日：2021-01-15

    申请人： THE METHODIST HOSPITAL SYSTEM

    发明人： Alessandro Grattoni ,  Xuewu Liu ,  Mauro Ferrari

    IPC分类号： B81B1/00 ,  B81C1/00 ,  A61M5/168

    摘要： Devices and methods for controlling molecular transport are disclosed herein. The devices include a membrane having a plurality of nanochannels extending therethrough. The membrane has an inner electrically conductive layer and an outer dielectric layer. The outer dielectric layer creates an insulative barrier between the electrically conductive layer and the contents of the nanochannels. At least one electrical contact region is positioned on a surface of the membrane. The electrical contact region exposes the electrically conductive layer of the membrane for electrical coupling to external electronics. When the membrane is at a first voltage, molecules flow through the nanochannels at a first release rate. When the membrane is at a second voltage, charge accumulation within the nanochannels modulates the flow of molecules through the nanochannels to a second release rate that is different than the first release rate. Methods of fabricating devices for controlling molecular transport are also disclosed herein.