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公开(公告)号：US20220402998A1
公开(公告)日：2022-12-22
申请号：US17772539
申请日：2020-10-30
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： WENSHE RAY LIU , WENYUE CAO
IPC: C07K14/725 , C07K14/705 , A61K35/17 , A61P35/00 , C12N9/50 , C07K16/28
Abstract: The subject invention pertains to a chimeric antigen receptor, a T cell comprising said CAR and methods of making and using said CAR and said T cell for the treatment of a cancer and/or an immune disease. In specific embodiments, the method comprises the use of T cells comprising CARs to target different antigens on target cells. In further specific embodiments, the CARs of the invention comprise NS3 protease domains and cleavage sites, which NS3 domains are inhibited by small molecule inhibitors for customized CAR-T cell therapy.
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公开(公告)号：US20220395615A1
公开(公告)日：2022-12-15
申请号：US17847426
申请日：2022-06-23
Applicant: The Texas A&M University System
Inventor： Rachael Muschalek , Keith Hearon , Landon D. Nash , Duncan J. Maitland
Abstract: An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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公开(公告)号：US11523998B2
公开(公告)日：2022-12-13
申请号：US16442075
申请日：2019-06-14
Applicant: The Texas A&M University System , Core Vibe Health, Inc.
Inventor： Susanne U. Mertens-Talcott , Ariela Betsy Thomas , Vinicius De Paula Venancio , Geoffrey R. Pfeifer , Blake M. Ebersole
IPC: A61K31/20 , A61P29/00 , A61K9/00 , A61K31/12 , A61K31/366
Abstract: Pharmaceutical or nutraceutical formulations are provided for treating inflammation in a subject in need thereof, as well as methods of treating inflammation in a subject in need thereof by administering one of the formulations. In some aspects, the pharmaceutical or nutraceutical formulation includes an effective amount of (i) palmitoylethanolamide or a derivative thereof, and (ii) one, two, three or more different small-molecule polyphenols or derivatives thereof to alleviate one or more causes or symptoms of the inflammation in the subject. In some aspects, the formulations include all three, e.g. the formulations includes (i) palmitoylethanolamide or a derivative thereof, (ii) quercetin or a derivative thereof, and (iii) curcumin or a derivative thereof. In some instances, the components (i)-(iii) discussed above are present at a mass ratio of about (i) 4 mg to 6 mg of palmitoylethanolamide or a derivative thereof to (ii) about 0.5 to 2.5 mg curcumin or a derivative thereof, and (iii) about 0.5 mg to 1.5 mg quercetin or a derivative thereof.
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公开(公告)号：US11523613B2
公开(公告)日：2022-12-13
申请号：US16494001
申请日：2018-03-16
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM , The United States Government as Represented by the Department of Veterans Affairs
Inventor： Virender K. Sharma , Chetan Jinadatha
Abstract: Methods for disinfecting a surface are provided which include contacting a surface with a solution comprising Fe(VI)O42−, thereby disinfecting the surfaces. In some cases, the surface to be contacted with the solution is in a space suitable for human occupancy and the surface is arranged in the ambient of the space. In addition, solutions comprising Fe(VI)O42− are provided. The solutions may additionally include a hypohalite salt and a surfactant.
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公开(公告)号：US11518903B2
公开(公告)日：2022-12-06
申请号：US16338958
申请日：2017-10-18
Applicant: The Texas A&M University System
Inventor： Jaime C. Grunlan , Merid Haile , Ryan Smith
IPC: C09D133/02 , C09D179/02 , C08J7/04 , C08J7/048 , B05D1/00 , B05D1/18 , B05D1/40
Abstract: A method of applying a gas-impermeable coating includes forming a polyelectrolyte complex suspension. The polyelectrolyte complex suspension is applied to a substrate. The substrate having the polyelectrolyte complex applied thereon is treated. The treating reduces salt content of the polyelectrolyte complex. The treating results in a gas-impermeable coating being formed on the substrate.
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Patent Agency Ranking
公开(公告)号：US11504339B2
公开(公告)日：2022-11-22
申请号：US17160836
申请日：2021-01-28
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Naga Venkata Ravi Kumar Majeti , Raghu Ganugula , Meenakshi Arora , Dianxiong Zou
IPC: A61K9/51 , A61K31/282 , A61K47/69
Abstract: The present disclosure provides nanoparticle compositions comprising i) a polymeric nanoparticle, ii) one or more ligands conjugated to the polymeric nanoparticle, and iii) urolithin A. The disclosure also provides methods and pharmaceutical compositions comprising the nanoparticle compositions for use in treating patients with various disease states.
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公开(公告)号：US20220361780A1
公开(公告)日：2022-11-17
申请号：US17769883
申请日：2020-10-16
Inventor： Madhav Erraguntla , Darpit K. Dave , Balakrishna Haridas , Daniel J. DeSalvo , Siripoom V. McKay , Mark Alan Lawley , Achu Geetha Byju
Abstract: A method for predicting a hypoglycemic event or a hyperglycemic event includes (a) collecting one or more data streams, wherein at least one of the one or more data streams includes a glucose (GL) data stream corresponding to a user, (b) determining one or more features based on the one or more collected data streams, wherein at least one of the one or more features is distinct from each of the one or more data streams, (c) generating a prediction of whether or not a hypoglycemic event or a hyperglycemic event will occur by a prediction model based on the one or more features determined at (b), and (d) issuing an alert to the user in response to the prediction generated at (c) including a prediction that a hypoglycemic event or a hyperglycemic event will occur.
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公开(公告)号：US11479355B2
公开(公告)日：2022-10-25
申请号：US16762516
申请日：2018-12-20
Applicant: The Texas A&M University System
Inventor： Moble Benedict , David A. Coleman
Abstract: A flapping-wing aircraft includes a support frame, a motor coupled to the support frame, a pair of wings coupled to the support frame, and a linkage assembly coupled to the support frame and configured to translate an output torque of the motor into flapping motion of the wings, wherein the linkage assembly includes a first link coupled to a rotational output of the motor, a second link pivotably coupled to the first link at a first pivot joint, a third link pivotably coupled to the second link at a second pivot joint, and a fourth link pivotably coupled to the support frame and slidably coupled to the third link, and wherein the fourth link is coupled to a first wing of the pair of wings.
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公开(公告)号：USPP34672P2
公开(公告)日：2022-10-18
申请号：US17242507
申请日：2021-04-28
Applicant: The Texas A&M University System
Inventor： Ambika Chandra , James C. Read
Abstract: ‘DALBG 1201’ is an F1 hybrid bluegrass with exceptional turfgrass quality, dark green color, high shoot density, medium-fine leaf texture, and ability to persist under a range of environmental stresses typically encountered in the southern United States.
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公开(公告)号：US20220312762A1
公开(公告)日：2022-10-06
申请号：US17640128
申请日：2020-09-06
Applicant: The Texas A&M University System
Inventor： Lawrence Griffing , Krishna Kumar
Abstract: In an embodiment, the present disclosure pertains to a method of inhibiting seed germination or modifying seedling growth. Generally, the method includes encapsulating or solubilizing sterols in an encapsulating agent and exposing a plant to the encapsulated or solubilized sterol in either a liquid or powdered-water-soluble form. In an additional embodiment, the present disclosure pertains to a composition that includes a sterol in an encapsulating agent in either a liquid or powdered-water-soluble form.
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