公开(公告)号：US3988458A

公开(公告)日：1976-10-26

申请号：US532458

申请日：1974-12-13

申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： A61K31/395 ,  A61K31/44 ,  C07D455/02 ,  C07D471/04 ,  A61K31/505

CPC分类号： C07D471/04 ,  A61K31/395 ,  A61K31/44 ,  C07D455/02

摘要： 2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.

摘要翻译： 在3-和5-位上具有羰基官能团的2,6-二氨基-1,4-二氢吡啶是低级烷基，苯基，取代的苯基或杂环基在4-位上被取代的是抗高血压剂和冠状血管扩张剂。 其中2,6-二氨基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸3,5-二乙酯是一个代表性的实施方案，通过脒与 醛或亚基甲酰乙酰乙酸酯。

公开(公告)号：US3987176A

公开(公告)日：1976-10-19

申请号：US531906

申请日：1974-12-12

申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： A61K31/455 ,  C07D401/04 ,  C07D409/04

CPC分类号： C07D401/04 ,  A61K31/455 ,  C07D409/04 ,  Y10S514/929

摘要： 3,4-Dihydropyridones of the formula ##SPC1##Wherein R.sup.1 is hydrogen, straight or branched chain alkyl, or --COOR' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; R.sup.2 is a straight, branched or cyclic, saturated or unsaturated hydrocarbon, aryl unsubstituted or substituted by 1 to 3 of the same or different substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro, cyano, trifluoromethyl, carbalkoxy and SO.sub.n --alkyl wherein n is 0, 1 or 2, or naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thenyl, furyl or pyrryl unsubstituted or substituted by 1 or more substituents selected from the group consisting of alkyl, alkoxy and halogen; and R.sup.3 is a straight or branched chain hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms, are produced by reacting an .alpha.,.beta.-unsaturated carboxylic acid ester of the formula ##EQU1## wherein R is alkyl, alkenyl or alkynyl, and R.sup.1 and R.sup.2 are as above defined, with an amidine of the formula ##EQU2## wherein R.sup.3 is as above defined. These compounds are useful as coronary agents and as anti-hypertensive agents.

公开(公告)号：US3966767A

公开(公告)日：1976-06-29

申请号：US526800

申请日：1974-11-25

申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： A61K31/35 ,  C07D309/22 ,  C07D409/04 ,  C07D333/24

CPC分类号： C07D309/22 ,  A61K31/35 ,  C07D409/04 ,  Y10S514/929

摘要： 2-Amino-4 H-pyrane derivatives of the formula ##SPC1##WhereinR.sup.1 and R.sup.2 are the same or different and each is hydrogen or straight- or branched-chain alkyl;R.sup.3 is straight- or branched-chain alkyl, phenyl or --COOR' wherein R' is a straight, branched or cyclic saturated or unsaturated aliphatic hydrocarbon;R.sup.4 is straight, branched or cyclic alkyl or alkenyl, aryl unsubstituted or substituted by 1, 2 or 3 of the same or different substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro, cyano, trifluoromethyl, carbalkoxy, and --SO.sub.n alkyl wherein n is 0, 1 or 2, orR.sup.4 is naphthyl, quinolyl, pyridyl, thienyl or furyl unsubstituted or substituted by alkyl, alkoxy or halogen;R.sup.5 is straight, branched or cyclic alkyl or --OR" wherein R" is a straight, branched or cyclic hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; andR.sup.6 is hydrogen or alkyl;Are useful for their strong coronary action and as anti-hypertensive agents.

摘要翻译： 式WHEREIN R1和R2的2-氨基-4H-吡喃衍生物相同或不同，各自为氢或直链或支链烷基; R3是直链或支链烷基，苯基或-COOR'，其中R'是直链，支链或环状的饱和或不饱和脂族烃; R4是直链，支链或环状的烷基或链烯基，未被取代或被1,2或3个相同或不同的选自烷基，烷氧基，卤素，硝基，氰基，三氟甲基，烷氧羰基和-SOn 烷基，其中n为0,1或2，或R4为萘基，喹啉基，吡啶基，噻吩基或呋喃基，未取代或被烷基，烷氧基或卤素取代; R5是直链，支链或环状烷基或-OR“，其中R”是直链，支链或环状烃或被1或2个氧原子间断的所述烃; R6为氢或烷基; 有用于其强大的冠状动脉和抗高血压药物。

公开(公告)号：US3959474A

公开(公告)日：1976-05-25

申请号：US523357

申请日：1974-11-13

申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： A61K31/455 ,  C07D211/90 ,  C07D401/04 ,  C07D405/04

CPC分类号： C07D401/04 ,  A61K31/455 ,  C07D211/90 ,  C07D405/04 ,  Y10S514/929

摘要： 2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.

摘要翻译： 在3-和5-位上具有羰基官能团的2,6-二氨基-1,4-二氢吡啶是低级烷基，苯基，取代的苯基或杂环基在4-位上被取代的是抗高血压剂和冠状血管扩张剂。 其中2,6-二氨基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸3,5-二乙酯是一个代表性的实施方案，通过脒与 醛或亚基甲酰乙酰乙酸酯。

公开(公告)号：US3951992A

公开(公告)日：1976-04-20

申请号：US531525

申请日：1974-12-11

申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： A61K31/455 ,  C07D401/04 ,  C07D409/04 ,  C07D213/70

CPC分类号： C07D401/04 ,  A61K31/455 ,  C07D409/04

摘要： 3,4-Dihydropyridones of the formula ##SPC1##Wherein R.sup.1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; R.sup.2 is a straight, branched or cyclic, saturated or unsaturated hydrocarbon, aryl unsubstituted or substituted by 1 to 3 of the same or different substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro, cyano, trifluoromethyl, carbalkoxy and SO.sub.n --alkyl wherein n is 0, 1 or 2, or naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thenyl, furyl or pyrryl unsubstituted or substituted by 1 or more substituents selected from the group consisting of alkyl, alkoxy and halogen; and R.sup.3 is a straight or branched chain hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms, are produced by reacting an .alpha.,.beta.-unsaturated carboxylic acid ester of the formula ##EQU1## wherein R is alkyl, alkenyl or alkynyl, and R.sup.1 and R.sup.2 are as above defined, with an amidine of the formula ##EQU2## wherein R.sup.3 is as above defined. These compounds are useful as coronary agents and as anti-hypertensive agents.

摘要翻译： 式WHEREIN R 1是氢，直链或支链烷基或-COOR'的3,4-二氢吡啶酮，其中R'是直链，支链或环状，饱和或不饱和烃或被1或2个氧原子间断的烃; R2是直链，支链或环状的饱和或不饱和的烃，未取代或被1至3个相同或不同的选自烷基，烷氧基，卤素，硝基，氰基，三氟甲基，碳烷氧基和SO- 烷基，其中n为0,1或2，或萘基，喹啉基，异喹啉基，吡啶基，嘧啶基，噻吩基，呋喃基或吡啶基，未取代或被一个或多个选自烷基，烷氧基和卤素的取代基取代; 并且R3是直链或支链烃或被1或2个氧原子间断的所述烃通过使式R 1 R 2 -CH = C ANGLE COOR的α，β-不饱和羧酸酯反应制备，其中R是烷基，烯基 或炔基，并且R 1和R 2如上所定义，与式H 2 N AN CLE C-CH 2 COOR 3 HN的脒反应，其中R 3如上所定义。 这些化合物可用作冠状动脉剂和抗高血压剂。

公开(公告)号：US3951990A

公开(公告)日：1976-04-20

申请号：US531999

申请日：1974-12-12

申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： A61K31/455 ,  C07D401/04 ,  C07D409/04 ,  C07D213/70

CPC分类号： C07D401/04 ,  A61K31/455 ,  C07D409/04 ,  Y10S514/929 ,  Y10S514/96

摘要： 3,4-Dihydropyridones of the formula ##SPC1##Wherein R.sup.1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; R.sup.2 is a straight, branched or cyclic, saturated or unsaturated hydrocarbon, aryl unsubstituted or substituted by 1 to 3 of the same or different substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro, cyano, trifluoromethyl, carbalkoxy and SO.sub.n --alkyl wherein n is 0, 1 or 2, or naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thenyl, furyl or pyrryl unsubstituted or substituted by 1 or more substituents selected from the group consisting of alkyl, alkoxy and halogen; and R.sup.3 is a straight or branched chain hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms, are produced by reacting an .alpha.,.beta.-unsaturated carboxylic acid ester of the formula ##EQU1## wherein R is alkyl, alkenyl or alkynyl, and R.sup.1 and R.sup.2 are as above defined, with an amidine of the formula ##EQU2## wherein R.sup.3 is as above defined. These compounds are useful as coronary agents and as anti-hypertensive agents.

摘要翻译： 式WHEREIN R 1是氢，直链或支链烷基或-COOR'的3,4-二氢吡啶酮，其中R'是直链，支链或环状，饱和或不饱和烃或被1或2个氧原子间断的烃; R2是直链，支链或环状的饱和或不饱和的烃，未取代或被1至3个相同或不同的选自烷基，烷氧基，卤素，硝基，氰基，三氟甲基，碳烷氧基和SO- 烷基，其中n为0,1或2，或萘基，喹啉基，异喹啉基，吡啶基，嘧啶基，噻吩基，呋喃基或吡啶基，未取代或被一个或多个选自烷基，烷氧基和卤素的取代基取代; 并且R3是直链或支链烃或被1或2个氧原子间断的所述烃通过使式R 1 R 2 -CH = C ANGLE COOR的α，β-不饱和羧酸酯反应制备，其中R是烷基，烯基 或炔基，并且R 1和R 2如上所定义，与式H 2 N AN CLE C-CH 2 COOR 3 HN的脒反应，其中R 3如上所定义。 这些化合物可用作冠状动脉剂和抗高血压剂。

公开(公告)号：US3951988A

公开(公告)日：1976-04-20

申请号：US468664

申请日：1974-05-10

申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： A61K31/395 ,  A61K31/44 ,  C07D455/02 ,  C07D471/04 ,  C07D213/55

CPC分类号： C07D471/04 ,  A61K31/395 ,  A61K31/44 ,  C07D455/02 ,  Y10S514/929

摘要： 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are antihypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative.

摘要翻译： 在3-位和5-位具有羰基官能团的1,4-二氢吡啶，任选被6位的低级烷基取代，在4-位被低级烷基，苯基，取代的苯基或杂环基取代，和 通过1-和2-位融合成五，六或七元环烷基环，其中一个亚甲基可以被硫，氧亚氨基或烷基亚氨基取代，是抗高血压剂和冠状血管扩张剂。 其中6-甲基-4-（3-硝基苯基）-1,2-戊烯-1,4-二氢吡啶-3,5-二羧酸3,5-二乙酯的代表性实施例是通过缩合 的亚乙酰乙酸酯和环状氨基羰基衍生物。

公开(公告)号：US3939171A

公开(公告)日：1976-02-17

申请号：US517732

申请日：1974-10-24

申请人： Horst Meyer ,  Freidrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Freidrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D213/55

CPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04

摘要： 2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.

摘要翻译： 在5-位上具有羰基官能团的2-氨基-1,4-二氢吡啶并且任选被6位的低级烷基或苯基取代，并且相应的2-氨基-1,4,5,6,7， 8-六氢-5-氧代喹啉，其衍生物进一步被3-位上的羰基取代，并且任选被4-位被低级烷基，苯基，取代的苯基或杂环基取代的是抗高血压剂和冠状血管扩张剂。 其中2-氨基-6-甲基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸3,5-二乙酯是其代表性实施方案的化合物是通过将 亚基乙酰乙酸酯和脒。

公开(公告)号：US3935220A

公开(公告)日：1976-01-27

申请号：US468741

申请日：1974-05-10

申请人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

发明人： Horst Meyer ,  Friedrich Bossert ,  Wulf Vater ,  Kurt Stoepel

IPC分类号： A61K31/395 ,  A61K31/44 ,  C07D455/02 ,  C07D471/04 ,  C07D213/46

CPC分类号： C07D471/04 ,  A61K31/395 ,  A61K31/44 ,  C07D455/02 ,  Y10S514/929

摘要： 1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are antihypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative.

摘要翻译： 在3-位和5-位具有羰基官能团的1,4-二氢吡啶，任选被6位的低级烷基取代，在4-位被低级烷基，苯基，取代的苯基或杂环基取代，和 通过1-和2-位融合成五，六或七元环烷基环，其中一个亚甲基可以被硫，氧亚氨基或烷基亚氨基取代，是抗高血压剂和冠状血管扩张剂。 其中6-甲基-4-（3-硝基苯基）-1,2-戊烯-1,4-二氢吡啶-3,5-二羧酸3,5-二乙酯的代表性实施例是通过缩合 的亚乙酰乙酸酯和环状氨基羰基衍生物。

公开(公告)号：US08188329B2

公开(公告)日：2012-05-29

申请号：US12056524

申请日：2008-03-27

申请人： Christian Nowottny ,  Horst Meyer ,  Matthias Grehl ,  Dieter Schäfer ,  Hans-Joachim Alt ,  Wilhelm Glab

发明人： Christian Nowottny ,  Horst Meyer ,  Matthias Grehl ,  Dieter Schäfer ,  Hans-Joachim Alt ,  Wilhelm Glab

IPC分类号： A62D3/00 ,  A62D3/40 ,  F23N5/00 ,  F23K3/00 ,  F23B90/00 ,  F23B99/00

CPC分类号： C22B7/001 ,  C22B11/021 ,  F23G5/0273 ,  F23G5/16 ,  F23G5/50 ,  F23G7/006 ,  F23G2207/102 ,  F23G2207/30 ,  F23G2208/10 ,  F23G2209/141 ,  Y02P10/214

摘要： A recycling furnace and method are provided for processing potentially explosive precious metal-containing materials having organic fractions that combust with great energy, the furnace including a switching facility for alternating operation of a burning-off chamber of the furnace between: (A) pyrolysis or carbonization under protective furnace gas in an atmosphere comprising maximally 6 wt-% oxygen, and (B) oxidative combustion of the organic fractions including carbon. The furnace has indirect heating and a control that determines the end of the pyrolysis or carbonization by a sensor and controls the switching facility to supply air or oxygen to the interior of the furnace. Steps (A) and (B) are carried out sequentially in the furnace chamber, wherein neither the batch is changed, nor the furnace is opened. After the end of step (A) is determined, step (B) proceeds right after the pyrolysis or carbonization by supplying air or oxygen. A dosing of liquid or liquefied substances during the pyrolysis is controlled by at least one parameter of post-combustion. Thermal post-combustion is used for two furnace chambers, one operated for pyrolysis or carbonization and the other operated as a combustion chamber.

摘要翻译： 提供了一种用于处理具有以大能量燃烧的有机部分的具有潜在爆炸性的含贵金属材料的回收炉和方法，所述炉包括用于在炉的燃烧室之间交替操作的切换设备：（A）热解或 在包含最大6重量％氧气的气氛中，在保护炉气体下进行碳化，和（B）包括碳的有机部分的氧化燃烧。 炉具有间接加热和控制，其通过传感器确定热解或碳化的结束，并控制切换设施以向炉内供应空气或氧气。 在炉室中依次进行步骤（A）和（B），其中两个批次都不改变，炉子也不打开。 在确定步骤（A）结束后，步骤（B）通过供应空气或氧气在热解或碳化之后立即进行。 在热解期间，液体或液化物质的剂量由后燃烧的至少一个参数控制。 热后燃烧用于两个炉室，一个用于热解或碳化，另一个用作燃烧室。