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公开(公告)号:US20210040545A1
公开(公告)日:2021-02-11
申请号:US17069535
申请日:2020-10-13
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ , Stefanie Ann Ward MORTIMER
IPC: C12Q1/6827 , C12Q1/6806 , G16B30/00
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20210032707A1
公开(公告)日:2021-02-04
申请号:US17068710
申请日:2020-10-12
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , G16B30/00 , C12Q1/6869 , C12N15/10 , C12Q1/6806 , C12Q1/6874
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20200325529A1
公开(公告)日:2020-10-15
申请号:US16913965
申请日:2020-06-26
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ , Stefanie Ann Ward MORTIMER
IPC: C12Q1/6827 , C12Q1/6806 , G16B30/00
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20200299785A1
公开(公告)日:2020-09-24
申请号:US16897038
申请日:2020-06-09
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , C12Q1/6874 , G16B30/00 , C12N15/10 , C12Q1/6806 , C12Q1/6869
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20200291487A1
公开(公告)日:2020-09-17
申请号:US16885079
申请日:2020-05-27
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , G16B30/00 , C12Q1/6806 , C12Q1/6874 , C12Q1/6869 , C12N15/10
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20200263239A1
公开(公告)日:2020-08-20
申请号:US16853241
申请日:2020-04-20
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ , Stefanie Ann Ward MORTIMER
IPC: C12Q1/6827 , G16B30/00 , C12Q1/6806
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20200224254A1
公开(公告)日:2020-07-16
申请号:US16711892
申请日:2019-12-12
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ , Stefanie Ann Ward MORTIMER
IPC: C12Q1/6827 , C12Q1/6806 , G16B30/00
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20190177803A1
公开(公告)日:2019-06-13
申请号:US16277724
申请日:2019-02-15
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , G16B30/00 , C12Q1/6806 , C12Q1/6874 , C12N15/10 , C12Q1/6869
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20190078164A1
公开(公告)日:2019-03-14
申请号:US16004337
申请日:2018-06-08
Applicant: GUARDANT HEALTH, INC.
Inventor: AmirAli TALASAZ
IPC: C12Q1/6886 , C12N15/10 , C12Q1/6883 , C12Q1/6869 , G06F19/22
Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.
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公开(公告)号:US20180120291A1
公开(公告)日:2018-05-03
申请号:US15796642
申请日:2017-10-27
Applicant: Guardant Health, Inc.
Inventor: HELMY ELTOUKHY , AmirAli TALASAZ
CPC classification number: G01N33/49 , A61B5/145 , C12Q1/6883 , G16B20/00 , G16H50/20
Abstract: A method for analyzing a disease state of a subject includes characterizing the subject's genetic information at two or more time points or instances with a genetic analyzer, e.g., a deoxyribonucleic acid (DNA) sequencer, and using the information from the two or more time points or instances to produce an adjusted test result in the characterization of the subject's genetic information.
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