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    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    81.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 有权

    公开(公告)号：US20210040545A1

    公开(公告)日：2021-02-11

    申请号：US17069535

    申请日：2020-10-13

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ ,  Stefanie Ann Ward MORTIMER

    IPC: C12Q1/6827 ,  C12Q1/6806 ,  G16B30/00

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    82.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 有权

    公开(公告)号：US20210032707A1

    公开(公告)日：2021-02-04

    申请号：US17068710

    申请日：2020-10-12

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ

    IPC: C12Q1/6886 ,  G16B30/00 ,  C12Q1/6869 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6874

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    83.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 审中-公开

    公开(公告)号：US20200325529A1

    公开(公告)日：2020-10-15

    申请号：US16913965

    申请日：2020-06-26

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ ,  Stefanie Ann Ward MORTIMER

    IPC: C12Q1/6827 ,  C12Q1/6806 ,  G16B30/00

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    84.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 审中-公开

    公开(公告)号：US20200299785A1

    公开(公告)日：2020-09-24

    申请号：US16897038

    申请日：2020-06-09

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ

    IPC: C12Q1/6886 ,  C12Q1/6874 ,  G16B30/00 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6869

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    85.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 审中-公开

    公开(公告)号：US20200291487A1

    公开(公告)日：2020-09-17

    申请号：US16885079

    申请日：2020-05-27

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ

    IPC: C12Q1/6886 ,  G16B30/00 ,  C12Q1/6806 ,  C12Q1/6874 ,  C12Q1/6869 ,  C12N15/10

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    86.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 审中-公开

    公开(公告)号：US20200263239A1

    公开(公告)日：2020-08-20

    申请号：US16853241

    申请日：2020-04-20

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ ,  Stefanie Ann Ward MORTIMER

    IPC: C12Q1/6827 ,  G16B30/00 ,  C12Q1/6806

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    87.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 审中-公开

    公开(公告)号：US20200224254A1

    公开(公告)日：2020-07-16

    申请号：US16711892

    申请日：2019-12-12

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ ,  Stefanie Ann Ward MORTIMER

    IPC: C12Q1/6827 ,  C12Q1/6806 ,  G16B30/00

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    88.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 审中-公开

    公开(公告)号：US20190177803A1

    公开(公告)日：2019-06-13

    申请号：US16277724

    申请日：2019-02-15

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ

    IPC: C12Q1/6886 ,  G16B30/00 ,  C12Q1/6806 ,  C12Q1/6874 ,  C12N15/10 ,  C12Q1/6869

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
    89.
    发明申请
    SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION 审中-公开

    公开(公告)号：US20190078164A1

    公开(公告)日：2019-03-14

    申请号：US16004337

    申请日：2018-06-08

    Applicant: GUARDANT HEALTH, INC.

    Inventor： AmirAli TALASAZ

    IPC: C12Q1/6886 ,  C12N15/10 ,  C12Q1/6883 ,  C12Q1/6869 ,  G06F19/22

    Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

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