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公开(公告)号：US07763456B2
公开(公告)日：2010-07-27
申请号：US11864698
申请日：2007-09-28
CPC分类号： B01L3/502753 , B01L3/5025 , B01L3/5027 , B01L2200/12 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , C12M23/16 , C12M25/14 , C12M35/08
摘要： A polymeric chip having at least one three-dimensional porous scaffold, a microfluidic channel inlet to the porous scaffold, and a microfluidic channel outlet from the porous scaffold. In one embodiment, the polymeric chip has two three-dimensional porous scaffolds: one scaffold comprises liver cells and the other scaffold comprises cancer cells. The chip can be used as a multi-organ tissue model system.
摘要翻译： 具有至少一个三维多孔支架，多孔支架的微流体通道入口和来自多孔支架的微流体通道出口的聚合物芯片。 在一个实施方案中，聚合物芯片具有两个三维多孔支架：一个支架包含肝细胞，另一个支架包含癌细胞。 该芯片可用作多器官组织模型系统。
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公开(公告)号：US07468375B2
公开(公告)日：2008-12-23
申请号：US11115003
申请日：2005-04-25
申请人： Klaus Ruprecht Dress , Qiyue Hu , Ted William Johnson , Michael Bruno Plewe , Steven Paul Tanis , Hai Wang , Anle Yang , Chunfeng Yin , Junhu Zhang
发明人： Klaus Ruprecht Dress , Qiyue Hu , Ted William Johnson , Michael Bruno Plewe , Steven Paul Tanis , Hai Wang , Anle Yang , Chunfeng Yin , Junhu Zhang
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，它们的合成及其作为人免疫缺陷病毒（“HIV”）整合酶的调节剂或抑制剂的用途。
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83.发明申请HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE 审中-公开HIV-INTEGRASE INHIBITORS，PHARMACEUTICAL COMPOSITIONS及其使用方法公开(公告)号：US20080221154A1
公开(公告)日：2008-09-11
申请号：US12043636
申请日：2008-03-06
申请人： Qiyue HU , Ted William Johnson , Atsuo Kuki , Michael Bruno Plewe , Dawn Marie Nowlin , Hai Wang , Junhu Zhang
发明人： Qiyue HU , Ted William Johnson , Atsuo Kuki , Michael Bruno Plewe , Dawn Marie Nowlin , Hai Wang , Junhu Zhang
IPC分类号： A61K31/437 , C12N9/99 , A61P31/18 , C12Q1/68
CPC分类号： C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicyclic hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
摘要翻译： 描述由式I表示的双环氧肟酸酯化合物。 双环异羟肟酸酯化合物和含有这些化合物的组合物可用于抑制或调节HIV整合酶的酶活性并治疗HIV介导的疾病和病症。
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84.发明授权HIV-Integrase inhibitors, pharmaceutical compositions and methods for their use 失效HIV整合酶抑制剂，药物组合物及其使用方法公开(公告)号：US07368571B2
公开(公告)日：2008-05-06
申请号：US11470301
申请日：2006-09-06
申请人： Qiyue Hu , Atsuo Kuki , Dawn Marie Nowlin , Michael Bruno Plewe , Hai Wang , Junhu Zhang
发明人： Qiyue Hu , Atsuo Kuki , Dawn Marie Nowlin , Michael Bruno Plewe , Hai Wang , Junhu Zhang
IPC分类号： C07D471/02 , C07D471/00
CPC分类号： C07D471/04 , C07D471/12 , C07D471/14
摘要： Bicycling hydroxamate compounds represented by the Formula I: are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated diseases and conditions.
摘要翻译： 描述由式I表示的骑自行车的异羟肟酸酯化合物。 双环异羟肟酸酯化合物和含有这些化合物的组合物可用于抑制或调节HIV整合酶的酶活性并治疗HIV介导的疾病和病症。
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公开(公告)号：US20060288434A1
公开(公告)日：2006-12-21
申请号：US11028803
申请日：2005-01-04
申请人： Hai Wang , Zhoufeng Chen , David Anderson
发明人： Hai Wang , Zhoufeng Chen , David Anderson
IPC分类号： A01K67/027 , A61K38/54
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , A61K39/3955 , A61K49/00 , A61K49/0002 , A61K49/0008 , C07K14/705 , C07K16/2866 , C07K16/30 , C07K2317/76 , C12N5/0691 , C12N2503/02 , G01N33/573 , G01N33/6863 , G01N2333/52
摘要： Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells and vein cells, for example.
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公开(公告)号：US20060154633A1
公开(公告)日：2006-07-13
申请号：US10542535
申请日：2003-01-29
申请人： Hai Wang
发明人： Hai Wang
IPC分类号： H04B17/00
CPC分类号： H04J13/20 , H04B1/7097 , H04B17/327 , H04B17/336 , H04J13/0044
摘要： An arrangement estimates the uplink SINR of a CDMA channel. It includes means (40) for estimating the signal power using the channelization code of the channel. A selector (28) searches for and selects an idle channelization code that is orthogonal to the channelization code of the channel. This idle code is used by further means (30) for estimating the power of interference plus noise. Means (42) then form the SINR estimate using these estimates.
摘要翻译： 一种装置估计CDMA信道的上行SINR。 它包括用于使用信道的信道化码来估计信号功率的装置（40）。 选择器（28）搜索并选择与信道的信道化码正交的空闲信道化码。 该空闲代码被用于估计干扰加噪声功率的另外的装置（30）使用。 然后使用这些估计来形成（42）的SINR估计。
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87.发明授权HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use 失效HIV整合酶抑制剂，药物组合物及其使用方法公开(公告)号：US07001912B2
公开(公告)日：2006-02-21
申请号：US10765227
申请日：2004-01-26
申请人： Atsuo Kuki , Xinqiang Li , Michael Bruno Plewe , Hai Wang , Junhu Zhang
发明人： Atsuo Kuki , Xinqiang Li , Michael Bruno Plewe , Hai Wang , Junhu Zhang
IPC分类号： A61K31/437 , C07D471/02 , C07D471/12
CPC分类号： C07D471/04
摘要： Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
摘要翻译： 由式（I）表示的β-咔啉异羟肟酸化合物
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公开(公告)号：US20050277662A1
公开(公告)日：2005-12-15
申请号：US11115003
申请日：2005-04-25
申请人： Klaus Dress , Qiyue Hu , Ted Johnson , Michael Plewe , Steven Tanis , Hai Wang , Anle Yang , Chunfeng Yin , Junhu Zhang
发明人： Klaus Dress , Qiyue Hu , Ted Johnson , Michael Plewe , Steven Tanis , Hai Wang , Anle Yang , Chunfeng Yin , Junhu Zhang
IPC分类号： A61K31/4745 , C07D213/00 , C07D471/02 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIV”) integrase enzyme.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，它们的合成及其作为人免疫缺陷病毒（“HIV”）整合酶的调节剂或抑制剂的用途。
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公开(公告)号：US06953780B2
公开(公告)日：2005-10-11
申请号：US10312012
申请日：2001-06-21
申请人： Keliang Liu , Wensheng Yu , Yuanjun Liang , Hai Wang , Yufen Zhao , Zhenkai Ding
发明人： Keliang Liu , Wensheng Yu , Yuanjun Liang , Hai Wang , Yufen Zhao , Zhenkai Ding
摘要： The instant invention relates to some tripeptide derivatives having activity against endothelin a process for preparing them, pharmaceutical composition containing the same and their use in prevention or treatment of some diseases associated with endothelin.
摘要翻译： 本发明涉及具有抗内皮素活性的一些三肽衍生物，其制备方法，含有该三肽衍生物的方法，含有该三肽衍生物的药物组合物及其在预防或治疗与内皮素相关的一些疾病中的用途。
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