公开(公告)号：US12128405B2

公开(公告)日：2024-10-29

申请号：US16925762

申请日：2020-07-10

Applicant: HandyLab, Inc.

Inventor： Kalyan Handique ,  Gene Parunak ,  Cecelia Haley

IPC: F16K99/00 ,  B01L3/00 ,  B01L7/00 ,  B81C1/00 ,  C12Q1/6806 ,  C12Q1/686

CPC classification number: B01L3/502738 ,  B01L3/502707 ,  B01L3/502723 ,  B01L7/52 ,  B81C1/00087 ,  C12Q1/6806 ,  C12Q1/686 ,  F16K99/0001 ,  B01L3/5025 ,  B01L2200/0684 ,  B01L2200/142 ,  B01L2300/0803 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2300/1827 ,  B01L2300/1844 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0694 ,  F16K2099/008 ,  F16K2099/0084

Abstract: The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve.

公开(公告)号：US20240263233A1

公开(公告)日：2024-08-08

申请号：US18427553

申请日：2024-01-30

Applicant: Becton, Dickinson and Company

Inventor： Raymond Brasil Cota ,  Jamie Ryan Moskwa ,  Germin Hanna Zaki ,  Jrhung Taylor Tsai ,  Yasaman Daghighi ,  Timothy Zheng Zhu

IPC: C12Q1/6876 ,  B01L3/00 ,  C12Q1/6806 ,  C12Q1/6874 ,  G01N33/68

CPC classification number: C12Q1/6876 ,  B01L3/5025 ,  B01L3/502761 ,  C12Q1/6874 ,  G01N33/6803 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/087 ,  B01L2400/043 ,  C12Q1/6806 ,  C12Q2600/16 ,  G01N2570/00

Abstract: Systems for processing a cellular sample are provided. Embodiments of the systems include a tray configured to receive a multi-microwell-array-flowcell cartridge, and a retrieval magnet assembly configured to apply a uniform magnetic force to flowcells of the cartridge when in an active position. Also provided are methods, which methods may include introducing a multi-microwell-array-flowcell cartridge into the system of the invention, loading a sample into the multi-microwell-array-flowcell cartridge, actuating the retrieval magnet assembly to the active position and applying the uniform magnetic force to the sample within the multi-microwell-array-flowcell cartridge to produce a processed sample, and collecting the processed sample from the multi-microwell-array-flowcell cartridge. In addition, multi-microwell-array-flowcell cartridges are disclosed. Embodiments of the subject cartridges include a plurality of fluidic lanes, each fluidic lane comprising, an inlet for receiving liquid, a flow cell comprising a microwell array, and an outlet for discharging liquid.

公开(公告)号：US12030050B2

公开(公告)日：2024-07-09

申请号：US17089426

申请日：2020-11-04

Applicant: HANDYLAB, INC.

Inventor： Kalyan Handique

IPC: B01L3/00 ,  B01L7/00 ,  B81C1/00 ,  C12Q1/6806 ,  C12Q1/686 ,  F16K99/00

CPC classification number: B01L3/502738 ,  B01L3/502707 ,  B01L3/502723 ,  B01L7/52 ,  B81C1/00087 ,  C12Q1/6806 ,  C12Q1/686 ,  F16K99/0001 ,  B01L3/5025 ,  B01L2200/0684 ,  B01L2200/142 ,  B01L2300/0803 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/14 ,  B01L2300/1827 ,  B01L2300/1844 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0677 ,  B01L2400/0694 ,  F16K2099/008 ,  F16K2099/0084

Abstract: The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve.

公开(公告)号：US12005409B2

公开(公告)日：2024-06-11

申请号：US15775245

申请日：2016-11-09

Applicant: HORIBA ABX SAS

Inventor： Florent Beauducel ,  Philippe Benezeth

IPC: G01N35/00 ,  B01F29/321 ,  B01L3/00 ,  G01N1/00 ,  G01N35/10 ,  B01L9/06 ,  B65G65/00 ,  C12Q1/68 ,  G01N33/96 ,  G01N35/04

CPC classification number: B01F29/321 ,  B01L3/5025 ,  G01N35/00732 ,  G01N35/0092 ,  G01N35/0099 ,  G01N35/1083 ,  B01L9/06 ,  B01L2300/021 ,  B65G65/00 ,  C12Q1/68 ,  G01N1/00 ,  G01N2001/002 ,  G01N33/96 ,  G01N35/00 ,  G01N2035/00524 ,  G01N2035/041 ,  G01N2035/0412 ,  G01N2035/042 ,  G01N2035/0472 ,  G01N2035/0493 ,  G01N35/10 ,  G01N2035/1058 ,  G01N35/1072

Abstract: A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes, a sampling apparatus capable of collecting a biological liquid sample in a tube, and a changer capable of gripping a tube on a rack received in the agitator and moving it to the sampling apparatus. The agitator is capable of agitating at least three racks simultaneously, and the device also comprises a scheduler capable of determining destination data for a tube and destination data for the rack which receives this tube, and of determining for each tube a final location based on the destination data of the tube and the destination data of the racks received in the device, which final location designates a rack, received on the agitator and a position on this rack and can be different from the location of the tube when the rack that received it has been introduced into the device, and arranged to control the changer in order to grip a tube, present it to the sampling apparatus and replace it after sampling at the final location.

公开(公告)号：US11899010B2

公开(公告)日：2024-02-13

申请号：US17664790

申请日：2022-05-24

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

CPC classification number: G01N33/5304 ,  A61B5/15 ,  A61B5/151 ,  A61B5/150755 ,  B01J19/0046 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L9/543 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G16H10/40 ,  A61B10/007 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J2219/005 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L7/5255 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N2035/0097 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/475 ,  G01N2333/4737 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/9129 ,  G01N2333/91205 ,  G01N2800/26 ,  G01N2800/60 ,  Y10T29/49826 ,  Y10T436/25375

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US11821890B2

公开(公告)日：2023-11-21

申请号：US17145954

申请日：2021-01-11

Applicant: Pinpoint Science Inc.

Inventor： Lisa Diamond

IPC: G01N33/487 ,  G01N27/12 ,  B01L3/00

CPC classification number: G01N33/48721 ,  B01L3/5025 ,  B01L3/5027 ,  G01N27/128 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0896 ,  C12Q2563/00 ,  C12Q2563/116 ,  C12Q2565/50 ,  C12Q2565/60

Abstract: Described herein are systems and methods of providing a nanosensor chip for detecting and/or quantifying target molecules in a solution. Said nanosensor chip comprises a pore comprising a plurality of nanopores. Said plurality of nanopores is functionalized with immobilized probe molecules for detecting the target molecules. The solution is directed to the nanochip to permit binding of said target molecules. Changes an aggregate current in response to target molecules in the liquid sample binding to the probe molecules are measured to detect and/or quantify said target molecules in said solution.

公开(公告)号：US20230338946A1

公开(公告)日：2023-10-26

申请号：US18344152

申请日：2023-06-29

Applicant: bioMerieux, Inc.

Inventor： Bruno Colin ,  Raymond O’Bear ,  Cecile Paris

IPC: B01L3/00

CPC classification number: B01L3/5025 ,  B01L3/502723 ,  B01L3/523 ,  B01L3/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2200/143 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0893 ,  B01L2400/049

Abstract: The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprise one or more fluid over-flow reservoirs, wherein the over-flow reservoirs are operatively connected to a distribution channel by a fluid over-flow channel. In another embodiment, the sample test cards may comprise a plurality of flow reservoirs operable to trap air thereby reducing and/or preventing well-to-well contamination. The test card of this invention may comprise from 80 to 140 individual sample wells, for example, in a test card sample test cards of the present invention have a generally rectangular shape sample test card having dimensions of from about 90 to about 95 mm in width, from about 55 to about 60 mm in height and from about 4 to about 5 mm in thickness.

公开(公告)号：US11713455B2

公开(公告)日：2023-08-01

申请号：US16782795

申请日：2020-02-05

Applicant: AMMR Joint Venture

Inventor： Regis Peytavi ,  Kiana Aran ,  Brett Goldsmith ,  Alexander Kane

IPC: C12N15/10 ,  C12N9/22 ,  C12N15/11 ,  B01L3/00 ,  G16B50/30

CPC classification number: C12N15/1013 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  C12N9/22 ,  C12N15/102 ,  C12N15/111 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2300/022 ,  B01L2300/0636 ,  C12N2310/20 ,  G16B50/30

Abstract: For enhanced selection of efficient targeted genome manipulating agents, an apparatus includes first and second chip-based biosensors having one or more sensing surfaces configured to detect biomolecular binding interactions between a nucleic acid sample and a targeted genome manipulating agent functionalized to a capture surface within a sensing range of the one or more sensing surfaces. The first chip-based biosensor uses a nucleic acid sample incubated with a blocking agent that blocks on-target binding and the second chip-based biosensor holds a nucleic acid sample that omits the blocking agent. A measurement apparatus measures first and second sets of response signals produced in response to the biomolecular binding interactions occurring between the nucleic acid sample and the targeted genome manipulating agent. An analysis module determines the genome manipulating efficiency parameters of the targeted genome manipulating agent. A system and a method perform the functions of the apparatus.

公开(公告)号：US20230201826A1

公开(公告)日：2023-06-29

申请号：US18116411

申请日：2023-03-02

Applicant: TOPPAN Inc.

Inventor： Keisuke GOTO ,  Yoichi MAKINO ,  Shinichi WADA ,  Yuichiro SHINOHARA

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/5025 ,  B01L2300/0829 ,  B01L2200/0689 ,  B01L2300/041

Abstract: A fluidic device including a substrate having a well array that includes regularly arranged wells that have a same shape and are open to a surface of the substrate, and a cover member facing the well array. The well array and the cover member are positioned to have a space therebetween, which forms a flow path through which a fluid flows, and the wells including a well A and a well B closest to the well A satisfy formula (1): 0.8≤Da/Dab

公开(公告)号：US11656225B2

公开(公告)日：2023-05-23

申请号：US16737238

申请日：2020-01-08

Applicant: Raouf A. Guirguis

Inventor： Raouf A. Guirguis

IPC: G01N33/543 ,  B01L3/00 ,  G01N1/18 ,  G01N1/02

CPC classification number: G01N33/54386 ,  B01L3/5023 ,  B01L3/5025 ,  B01L3/5029 ,  G01N1/18 ,  B01L2200/141 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/0825 ,  B01L2400/0478 ,  G01N2001/028

Abstract: An apparatus for testing a fluid sample including a sample receiving member having an opening for receiving a fluid sample, wherein the sample receiving member comprises at least a first and second sample collection chambers, a sample retention member, in fluid communication with the first sample collection chamber, to retain a portion of the fluid sample, and at least one test strip, in fluid communication with the second collection chamber, to indicate the presence or absence of at least one analyte in the fluid sample, wherein the first collection chamber is not in fluid communication with the second collection chamber.