公开(公告)号：US20220211489A1

公开(公告)日：2022-07-07

申请号：US17611298

申请日：2020-04-09

申请人： Junzhong Liang ,  Ling Yu

发明人： Junzhong Liang ,  Ling Yu

IPC分类号： A61F2/16 ,  A61F9/008 ,  G02C7/04

摘要： Methods and devices are provided for wavefront treatments of an eye's astigmatism, coma, and presbyopia. Wavefront-engineered monofocal lenses, inducing spherical aberration into the eye's central pupil, provide vision correction beyond 20/20 acuity and improve quality of vision by eliminating image distortion caused by uncorrected astigmatism and coma in the eye. New presbyopia-correcting lenses, including Extended Depth of Focus (EDOF) bifocal, EDOF trifocal, and quasi-accommodating lenses, are disclosed for presbyopia corrections between +0.75 D to +3.25 D, and they are achieved by inducing a positive spherical aberration and a positive focus offset less than 3 Diopters in a central section plus a negative spherical aberration in an annular section within a central part of a monofocal lens. These wavefront lenses can be adapted for contact lenses, implantable contact lenses, Intraocular Lenses (IOLs), phakic IOLs, accommodating IOLs, corneal inlays, as well as eyepieces for Virtual Reality (VR) displays, game goggles, microscopes, telescopes.

公开(公告)号：US08497712B2

公开(公告)日：2013-07-30

申请号：US13475937

申请日：2012-05-18

申请人： Andy Nguyen ,  Ling Yu

发明人： Andy Nguyen ,  Ling Yu

IPC分类号： H03K5/22

CPC分类号： G01R19/16552

摘要： A circuit includes a comparator, a programmable current source, and a control circuit. The comparator is operable to compare an internal supply voltage of the circuit to a reference voltage. The programmable current source is operable to supply a first current for the reference voltage. The control circuit is operable to control the first current through the programmable current source based on an output signal of the comparator.

摘要翻译： 电路包括比较器，可编程电流源和控制电路。 比较器可操作以将电路的内部电源电压与参考电压进行比较。 可编程电流源可操作地为参考电压提供第一电流。 控制电路可操作以基于比较器的输出信号来控制通过可编程电流源的第一电流。

公开(公告)号：US08232826B1

公开(公告)日：2012-07-31

申请号：US12692847

申请日：2010-01-25

申请人： Andy Nguyen ,  Ling Yu ,  Ryan Fung

发明人： Andy Nguyen ,  Ling Yu ,  Ryan Fung

IPC分类号： H03H11/26

CPC分类号： H03K17/005

摘要： A circuit with N primary outputs and a delay chain with M selection multiplexers. M can be less than N, and M is based on the number of primary outputs that simultaneously require a delayed signal from the delay chain. The N primary outputs may include core outputs and/or registers. Each of the M selection multiplexers feed directly or indirectly a subset of the N primary outputs.

摘要翻译： 具有N个主输出的电路和具有M个选择多路复用器的延迟链。 M可以小于N，M基于同时需要来自延迟链的延迟信号的主输出的数量。 N个主输出可以包括核心输出和/或寄存器。 每个M选择多路复用器直接或间接馈送N个主输出的子集。

公开(公告)号：US20120148598A1

公开(公告)日：2012-06-14

申请号：US13309490

申请日：2011-12-01

申请人： Soldano Ferrone ,  Xinhui Wang ,  Elvira Favoino ,  Ling Yu ,  Yangyang Wang

发明人： Soldano Ferrone ,  Xinhui Wang ,  Elvira Favoino ,  Ling Yu ,  Yangyang Wang

IPC分类号： A61K39/395 ,  A61P35/04 ,  A61P35/00

CPC分类号： C07K16/18 ,  A61K31/437 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  A61K2300/00

摘要： Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds glucose regulated protein (GRP) 94; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.

摘要翻译： 本文公开了对治疗肿瘤具有协同作用的药剂的组合。 这些药剂组合可用于治疗肿瘤，其中癌细胞表达突变的BRAF。 公开了用于治疗诊断患有表达突变型BRAF的肿瘤的受试者的方法。 所述方法包括向受试者（1）施用治疗有效量的特异性结合葡萄糖调节蛋白（GRP）94的抗体或其抗原结合片段; 和（2）治疗有效量的BRAF抑制剂。 在一些实施方案中，肿瘤是黑素瘤。 在一些实施方案中，该方法包括选择具有对BRAF抑制剂的一级或二级抗性的受试者。 在另外的实施方案中，治疗肿瘤包括减少肿瘤的转移。 在另外的实施方案中，BRAF抑制剂包括PLX4032或PLX4720。

公开(公告)号：US08081503B1

公开(公告)日：2011-12-20

申请号：US12395598

申请日：2009-02-27

申请人： Andy Nguyen ,  Ling Yu

发明人： Andy Nguyen ,  Ling Yu

IPC分类号： G11C11/00

CPC分类号： G11C8/10 ,  G11C11/413

摘要： Arrays of memory elements may have data lines and address lines. Each memory element may have five transistors. An address decoder may receive an undecoded address signal and may produce a corresponding decoded address signal. The decoded version of the address signal may be used in addressing the memory elements in the memory array. The memory array may be loaded with configuration data. Loaded memory elements may each provide a static output control signal that configures a programmable logic transistor in programmable logic. The memory elements may be powered with an elevated voltage during normal operation. Boosted address signals may be used when addressing the memory array. The address decoder may contain circuitry that is responsive to a clear control signal and an address output enable signal. The memory element array may be cleared by asserting the clear control signal and address output enable signal.

摘要翻译： 存储器元件的阵列可以具有数据线和地址线。 每个存储元件可以具有五个晶体管。 地址解码器可以接收未编码的地址信号并且可以产生对应的解码的地址信号。 地址信号的解码版本可以用于寻址存储器阵列中的存储器元件。 存储器阵列可以被加载配置数据。 加载的存储器元件可以各自提供将可编程逻辑晶体管配置为可编程逻辑的静态输出控制信号。 存储元件可以在正常操作期间用升高的电压供电。 在寻址存储器阵列时可以使用增强的地址信号。 地址解码器可以包含响应于清除控制信号和地址输出使能信号的电路。 可以通过断言清除控制信号和地址输出使能信号来清除存储元件阵列。

公开(公告)号：US20080045262A1

公开(公告)日：2008-02-21

申请号：US11557324

申请日：2006-11-07

申请人： Vanvinh Phan ,  Ling Yu ,  Markku Vainikka

发明人： Vanvinh Phan ,  Ling Yu ,  Markku Vainikka

IPC分类号： H04B7/00 ,  H04Q7/20

CPC分类号： H04W36/00837 ,  H04W8/18 ,  H04W36/14 ,  H04W48/18

摘要： An approach is provided for cell selection or reselection in a multi-radio network environment involving at least two different radio access technologies. A service preference information which indicates service preferences for different radio access technologies can be set at a network element and be sent to at least one terminal device. At the terminal device, the service preference information is detected and a serving cell is selected based on the detected service preference information. Thereby, the network is capable of performing service-based control of cell selection or reselection of the terminal device upon initiating access for a certain service in an overlaid multi-RAT environment. This in turn enhances network utility, operation and performance.

摘要翻译： 提供了一种在涉及至少两种不同无线电接入技术的多无线电网络环境中的小区选择或重选的方法。 可以将表示不同无线接入技术的服务偏好的服务偏好信息设置在网元上，并发送给至少一个终端设备。 在终端装置中，根据检测到的服务偏好信息检测服务偏好信息，选择服务小区。 因此，网络能够在重叠的多RAT环境中的特定服务发起访问时，执行基于服务的小区选择控制或终端设备的重新选择。 这反过来又增强了网络的实用性，操作性和性能。

公开(公告)号：US09296811B2

公开(公告)日：2016-03-29

申请号：US13991136

申请日：2011-12-01

申请人： Soldano Ferrone ,  Xinhui Wang ,  Elvira Favoino ,  Ling Yu ,  Yangyang Wang

发明人： Soldano Ferrone ,  Xinhui Wang ,  Elvira Favoino ,  Ling Yu ,  Yangyang Wang

IPC分类号： A61K39/395 ,  A61K31/437 ,  A61K45/06 ,  C07K16/18 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K31/437 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  A61K2300/00

摘要： Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds high molecular weight melanoma associated antigen (HMW-MAA), also known as CSPG4; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.

摘要翻译： 本文公开了对治疗肿瘤具有协同作用的药剂的组合。 这些药剂组合可用于治疗肿瘤，其中癌细胞表达突变的BRAF。 公开了用于治疗诊断患有表达突变型BRAF的肿瘤的受试者的方法。 所述方法包括向受试者（1）施用治疗有效量的特异性结合高分子量黑素瘤相关抗原（HMW-MAA）（也称为CSPG4）的抗体或其抗原结合片段; 和（2）治疗有效量的BRAF抑制剂。 在一些实施方案中，肿瘤是黑素瘤。 在一些实施方案中，该方法包括选择具有对BRAF抑制剂的一级或二级抗性的受试者。 在另外的实施方案中，治疗肿瘤包括减少肿瘤的转移。 在另外的实施方案中，BRAF抑制剂包括PLX4032或PLX4720。

公开(公告)号：US08771687B2

公开(公告)日：2014-07-08

申请号：US13309490

申请日：2011-12-01

申请人： Soldano Ferrone ,  Xinhui Wang ,  Elvira Favoino ,  Ling Yu ,  Yangyang Wang

发明人： Soldano Ferrone ,  Xinhui Wang ,  Elvira Favoino ,  Ling Yu ,  Yangyang Wang

IPC分类号： A61K39/395

CPC分类号： C07K16/18 ,  A61K31/437 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  A61K2300/00

摘要： Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds glucose regulated protein (GRP) 94; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.

摘要翻译： 本文公开了对治疗肿瘤具有协同作用的药剂的组合。 这些药剂组合可用于治疗肿瘤，其中癌细胞表达突变的BRAF。 公开了用于治疗诊断患有表达突变型BRAF的肿瘤的受试者的方法。 所述方法包括向受试者（1）施用治疗有效量的特异性结合葡萄糖调节蛋白（GRP）94的抗体或其抗原结合片段; 和（2）治疗有效量的BRAF抑制剂。 在一些实施方案中，肿瘤是黑素瘤。 在一些实施方案中，该方法包括选择具有对BRAF抑制剂的一级或二级抗性的受试者。 在另外的实施方案中，治疗肿瘤包括减少肿瘤的转移。 在另外的实施方案中，BRAF抑制剂包括PLX4032或PLX4720。

公开(公告)号：US20110204924A1

公开(公告)日：2011-08-25

申请号：US13103832

申请日：2011-05-09

申请人： Andy Nguyen ,  Ling Yu

发明人： Andy Nguyen ,  Ling Yu

IPC分类号： H03K5/22

CPC分类号： G01R19/16552

摘要： A circuit includes a comparator, a resistor divider, a control circuit, a multiplexer, and a programmable gain amplifier. The comparator is operable to measure an internal voltage of the circuit based on a selected reference voltage. The resistor divider is operable to generate reference voltages. The control circuit is operable to generate a select signal based on an output signal of the comparator. The multiplexer is operable to select one of the reference voltages from the resistor divider as the selected reference voltage based on the select signal. The programmable gain amplifier is configurable to generate a compensation voltage to compensate for an offset voltage of the comparator. The compensation voltage is provided to an input of the comparator.

摘要翻译： 电路包括比较器，电阻分压器，控制电路，多路复用器和可编程增益放大器。 比较器可操作以基于所选择的参考电压来测量电路的内部电压。 电阻分压器可操作以产生参考电压。 控制电路可操作以基于比较器的输出信号产生选择信号。 多路复用器可操作以基于选择信号从电阻分压器中选择参考电压中的一个作为所选参考电压。 可编程增益放大器可配置为产生补偿电压以补偿比较器的偏移电压。 补偿电压被提供给比较器的输入端。

公开(公告)号：US07944248B2

公开(公告)日：2011-05-17

申请号：US12105262

申请日：2008-04-17

申请人： Andy Nguyen ,  Ling Yu

发明人： Andy Nguyen ,  Ling Yu

IPC分类号： H03K5/22

CPC分类号： G01R19/16552

摘要： A circuit can include a comparator, a resistor divider, a control circuit, and a multiplexer. The comparator compares an internal supply voltage of the circuit to a selected reference voltage. The resistor divider generates reference voltages. The control circuit receives an output signal of the comparator and generates a select signal. The multiplexer transmits one of the reference voltages from the resistor divider to the comparator as the selected reference voltage in response to the select signal.

摘要翻译： 电路可以包括比较器，电阻分压器，控制电路和多路复用器。 比较器将电路的内部电源电压与选定的参考电压进行比较。 电阻分压器产生参考电压。 控制电路接收比较器的输出信号并产生选择信号。 复用器响应于选择信号，将参考电压中的一个从电阻分压器传送到比较器作为选择的参考电压。