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公开(公告)号：US20240206722A1
公开(公告)日：2024-06-27
申请号：US18557796
申请日：2022-04-27
申请人： Junzhong Liang , Ling Yu
发明人： Junzhong Liang , Ling Yu
CPC分类号： A61B3/028 , A61B3/1015 , A61B3/103
摘要： Methods and systems are disclosed for optimizing refractive prescriptions of human eyes. First, objective refraction devices such as aberrometers and auto-refractors will not only provide an objective estimate of sphero-cylinder correction, but also a quality metrics for at least one of a) measuring the confidence level in the objectively determined cylinder power and cylinder axis in addition to the objective sphero-cylinder correction, b) assessing/displaying quality of vision corrections for a plurality of cylinder power. Second, the quality metrics will be used to elect one of a plurality of modes of subjective refraction with a phoropter: 1) one mode for the subjective determination of spherical power only, 2) another mode for subjective determination of both sphere power and cylinder power.
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2.发明申请公开(公告)号：US20220211489A1
公开(公告)日：2022-07-07
申请号：US17611298
申请日：2020-04-09
申请人： Junzhong Liang , Ling Yu
发明人： Junzhong Liang , Ling Yu
摘要： Methods and devices are provided for wavefront treatments of an eye's astigmatism, coma, and presbyopia. Wavefront-engineered monofocal lenses, inducing spherical aberration into the eye's central pupil, provide vision correction beyond 20/20 acuity and improve quality of vision by eliminating image distortion caused by uncorrected astigmatism and coma in the eye. New presbyopia-correcting lenses, including Extended Depth of Focus (EDOF) bifocal, EDOF trifocal, and quasi-accommodating lenses, are disclosed for presbyopia corrections between +0.75 D to +3.25 D, and they are achieved by inducing a positive spherical aberration and a positive focus offset less than 3 Diopters in a central section plus a negative spherical aberration in an annular section within a central part of a monofocal lens. These wavefront lenses can be adapted for contact lenses, implantable contact lenses, Intraocular Lenses (IOLs), phakic IOLs, accommodating IOLs, corneal inlays, as well as eyepieces for Virtual Reality (VR) displays, game goggles, microscopes, telescopes.
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公开(公告)号：US20240206723A1
公开(公告)日：2024-06-27
申请号：US18557113
申请日：2022-04-27
申请人： Junzhong Liang , Ling Yu
发明人： Junzhong Liang , Ling Yu
CPC分类号： A61B3/0285 , A61B3/0033 , A61B3/032
摘要： A refraction system for remote refraction or self-refraction of human eyes. The system uses a reliable spherocylindrical module that allows the refraction system to obtain an initial spherocylindrical correction of the eye, and an SPH adjustment module that allows the user to adjust spherical power of the phoropter module on top of the initial spherocylindrical correction of the eye so that an updated spherical power (SPH) is subjectively determined. The reliable spherocylindrical module can be I) a device for obtaining a prescription of a pair of old eyeglasses, or II) a wavefront aberrometer that can offer, in addition to the objective sphero-cylinder correction, a quality metrics for at least one of a) measuring the confidence level in the objectively determined cylinder power and cylinder axis, b) assessing/displaying quality of vision corrections for a plurality of cylinder power.
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公开(公告)号：US11998271B2
公开(公告)日：2024-06-04
申请号：US17285449
申请日：2018-10-25
发明人： Junzhong Liang , Ling Yu
CPC分类号： A61B3/032 , A61B3/0058 , A61B3/0285 , A61B3/103
摘要： Methods and systems am disclosed in which an optical diagnosis of an eye's optical image quality is performed using a simulated retinal image. An objective measurement of a total wave aberration is obtained, and residual aberrations are computed by subtracting a sphero-cylindrical correction from the total wave aberration. The simulated retinal image is computed by computing a point-spread function from the residual aberrations and convolving the computed point-spread function with an acuity chart. The optical diagnosis includes at least one of: determining excess aberrations, ranking optics of the eye into optical grades, selecting the eye for high-definition eyeglasses, identifying amblyopia or macular diseases, or choosing an objective refraction for vision correction.
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公开(公告)号：US09973992B2
公开(公告)日：2018-05-15
申请号：US14407130
申请日：2012-06-29
申请人： Vinh Van Phan , Ling Yu , Kari Veikko Horneman
发明人： Vinh Van Phan , Ling Yu , Kari Veikko Horneman
IPC分类号： H04W4/00 , H04W36/22 , H04W28/08 , H04W36/00 , H04W36/26 , H04W48/16 , H04W72/04 , H04W48/18 , H04W88/06
CPC分类号： H04W36/22 , H04W28/08 , H04W36/0066 , H04W36/26 , H04W48/16 , H04W48/18 , H04W72/042 , H04W88/06
摘要： A method for radio access offloading is disclosed, wherein the method includes maintaining, in a user terminal pre-configuration information on integrated local area radio access offloading layers. In response to detecting an access point of an available offloading layer, the user terminal may activate a local area radio access offloading mode. The user terminal transmits, to the base station via the access point, an indication indicating that the offloading mode is activated, and receives, from the base station, a confirmation indicating that the activated offloading mode is accepted by the base station. The user terminal then decides, whether or not to switch to the available offloading layer, wherein if the user terminal decides to switch to the available offloading layer, offloading is performed via the access point.
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公开(公告)号：US09814094B2
公开(公告)日：2017-11-07
申请号：US14395029
申请日：2012-04-17
申请人： Vinh Van Phan , Ling Yu , Kari Veikko Horneman
发明人： Vinh Van Phan , Ling Yu , Kari Veikko Horneman
CPC分类号： H04W84/18 , H04L41/0806 , H04W8/26 , H04W16/24 , H04W84/22
摘要： A method for providing an ad-hoc network provided, wherein at least one group of mobile devices operate as a device-to-device cluster having a currently elected cluster head device. The method comprises configuring, in a network apparatus for the device-to-device cluster, a cluster-specific cell-level radio network temporary identifier C-RNTI on the basis of a content-sharing service requested within the device-to-device cluster. C-RNTI is used to act as a cluster-specific virtual radio access user responsible for transmission between a serving base station and the currently elected cluster head device on behalf of the device-to-device cluster.
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7.发明授权公开(公告)号：US09807809B2
公开(公告)日：2017-10-31
申请号：US14375881
申请日：2012-01-31
IPC分类号： H04W4/22 , H04W76/02 , H04W64/00 , H04W4/00 , H04W4/02 , H04W72/04 , H04W76/00 , H04W84/20 , H04W88/06
CPC分类号： H04W76/023 , H04W4/021 , H04W4/50 , H04W4/90 , H04W64/00 , H04W72/048 , H04W76/14 , H04W76/50 , H04W84/20 , H04W88/06
摘要： One kind of communication is referred to as device-to-device D2D communication. Misuse is an issue for this type of communication. For example a public safety network may permit D2D communication to operate in an area following a natural or other incident where the controlling network entity loses coverage. However this permission to allow D2D communication without the controlling entity can lead to users of D2D apparatus such as public safety communications devices configured for use in a first region being able to perform D2D communications in a second region in licensed bands that are illegal or not permitted. Furthermore, each device should be configured to setup an ad hoc network using D2D only in those areas where the licensed bands can be used legally by the device. Therefore, each device determines its position and blocks D2D operation when outside of a geographical area to which it was configured.
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公开(公告)号：US09749856B2
公开(公告)日：2017-08-29
申请号：US14409767
申请日：2012-06-20
申请人： Vinh Van Phan , Ling Yu , Kari Veikko Horneman
发明人： Vinh Van Phan , Ling Yu , Kari Veikko Horneman
摘要： Methods and apparatuses for providing services for a mobile device with access to a cellular system are disclosed. In accordance with a method a mobile device sends to a cellular system a request for a service by a machine type device. The request includes information identifying the machine type device for use by the cellular system that is then used in exchange of information in relation to at least one of authentication, authorization and configuration. Information associated with configuration of a device-to-machine connection to the machine type device is then sent to the mobile device. The device-to-machine connection for use of the service is then established between the machine type device and the mobile device based on the received information. In another embodiment the mobile device contact the machine type device first and provides the machine type device with information assigned by the cellular system.
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公开(公告)号：US09113395B2
公开(公告)日：2015-08-18
申请号：US13511166
申请日：2009-11-27
申请人： Vinh Van Phan , Ling Yu , Kari Veikko Horneman , Ottmar Aumann
发明人： Vinh Van Phan , Ling Yu , Kari Veikko Horneman , Ottmar Aumann
CPC分类号： H04W48/10 , H04W4/06 , H04W8/005 , H04W48/12 , H04W72/02 , H04W72/0453 , H04W72/048 , H04W88/06
摘要： There is provided an improved solution for performing beacon broadcasting in a device-to-device communication network. The solution includes selecting, by a node capable of entering a device-to-device communication network, a channel for broadcasting wherein the selection is based on at least one of the following: the characteristics of the node and the state of the node; and causing a broadcast of information related to at least part of the properties of the node on the selected channel.
摘要翻译： 提供了一种用于在设备到设备通信网络中执行信标广播的改进的解决方案。 解决方案包括由能够进入设备到设备通信网络的节点选择用于广播的频道，其中所述选择基于以下中的至少一个：节点的特性和节点的状态; 并且引起与所选择的信道上的节点的至少部分属性相关的信息的广播。
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10.发明申请METHODS FOR TREATING A TUMOR USING AN ANTIBODY THAT SPECIFICALLY BINDS GRP94 审中-公开使用特异性GRP94抗体治疗肿瘤的方法公开(公告)号：US20140234324A1
公开(公告)日：2014-08-21
申请号：US14268925
申请日：2014-05-02
申请人： Soldano Ferrone , Xinhui Wang , Elvira Favoino , Ling Yu , Yangyang Wang
发明人： Soldano Ferrone , Xinhui Wang , Elvira Favoino , Ling Yu , Yangyang Wang
IPC分类号： C07K16/18 , A61K45/06 , A61K39/395 , A61K31/437
CPC分类号： C07K16/18 , A61K31/437 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/3053 , C07K2317/21 , C07K2317/622 , C07K2317/73 , A61K2300/00
摘要： Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds glucose regulated protein (GRP) 94; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.
摘要翻译： 本文公开了对治疗肿瘤具有协同作用的药剂的组合。 这些药剂组合可用于治疗肿瘤，其中癌细胞表达突变的BRAF。 公开了用于治疗诊断患有表达突变型BRAF的肿瘤的受试者的方法。 所述方法包括向受试者（1）施用治疗有效量的特异性结合葡萄糖调节蛋白（GRP）94的抗体或其抗原结合片段; 和（2）治疗有效量的BRAF抑制剂。 在一些实施方案中，肿瘤是黑素瘤。 在一些实施方案中，该方法包括选择具有对BRAF抑制剂的一级或二级抗性的受试者。 在另外的实施方案中，治疗肿瘤包括减少肿瘤的转移。 在另外的实施方案中，BRAF抑制剂包括PLX4032或PLX4720。
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