公开(公告)号：US20140378520A1

公开(公告)日：2014-12-25

申请号：US14477606

申请日：2014-09-04

申请人： NEKTAR THERAPEUTICS

发明人： Zhongxu Ren ,  Jennifer Riggs-Sauthier ,  Michael D. Bentley

IPC分类号： C07D233/94

CPC分类号： C07D233/94 ,  A61K47/48215 ,  A61K47/60

摘要： The invention provides (among other things) small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.

摘要翻译： 本发明提供了（尤其是）通过共价连接水溶性低聚物化学改性的小分子药物。

公开(公告)号：US20140288315A1

公开(公告)日：2014-09-25

申请号：US14297149

申请日：2014-06-05

申请人： NEKTAR THERAPEUTICS

发明人： Jennifer Riggs-Sauthier

IPC分类号： C07D207/27

CPC分类号： A61K31/4015 ,  A61K31/765 ,  A61K47/60 ,  C07D207/267 ,  C07D207/27

摘要： The invention relates to (among other things) oligomer-containing pyrrolidine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.

摘要翻译： 本发明涉及（尤其是）含低聚物的吡咯烷化合物。 当通过任何多种施用途径给药时，本发明的化合物显示出相对于缺乏寡聚物的相应化合物的一个或多个优点。

公开(公告)号：US20130338204A1

公开(公告)日：2013-12-19

申请号：US13971391

申请日：2013-08-20

申请人： Nektar Therapeutics

发明人： Jennifer Riggs-Sauthier ,  Wen Zhang

IPC分类号： A61K47/48

CPC分类号： A61K47/48215 ,  A61K47/60

摘要： The invention relates to (among other things) oligomer-dantrolene conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.

摘要翻译： 本发明涉及（尤其是）低聚物 - 丹曲林共轭物和相关化合物。 本发明的缀合物当通过任何多种施用途径施用时，显示出优于先前施用的化合物的优点。

公开(公告)号：US11464788B2

公开(公告)日：2022-10-11

申请号：US15788626

申请日：2017-10-19

申请人： Nektar Therapeutics

发明人： Wen Zhang ,  Jennifer Riggs-Sauthier ,  J. Milton Harris ,  Michael D. Bentley

IPC分类号： A61K31/573 ,  C07J41/00 ,  A61K47/60 ,  A61K47/59

摘要： The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water-soluble oligomer.

公开(公告)号：US20200323992A1

公开(公告)日：2020-10-15

申请号：US16912065

申请日：2020-06-25

申请人： Nektar Therapeutics

发明人： Lin Cheng ,  Jennifer Riggs-Sauthier

IPC分类号： A61K47/60

摘要： Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of pemetrexed-based compounds. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the pemetrexed-based compound is achieved.

公开(公告)号：US20200038517A1

公开(公告)日：2020-02-06

申请号：US16599605

申请日：2019-10-11

申请人： Nektar Therapeutics

发明人： Xuyuan Gu ,  Jennifer Riggs-Sauthier

IPC分类号： A61K47/60

摘要： The invention relates to (among other things) oligomer-phenothiazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated phenothiazine compounds.

公开(公告)号：US20190029991A1

公开(公告)日：2019-01-31

申请号：US16026979

申请日：2018-07-03

申请人： Nektar Therapeutics

发明人： Antoni Kozlowski ,  Samuel P. McManus ,  Jennifer Riggs-Sauthier ,  Xiaoming Shen ,  Wen Zhang

IPC分类号： A61K31/337 ,  A61K38/00 ,  C08G65/333 ,  C08G65/332 ,  A61K31/4745 ,  C08G79/08 ,  A61K31/785 ,  A61K47/60

摘要： Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

公开(公告)号：US20180185496A1

公开(公告)日：2018-07-05

申请号：US15910830

申请日：2018-03-02

申请人： Nektar Therapeutics

发明人： Jennifer Riggs-Sauthier ,  Stephanie Allums-Donald ,  Sean M. Culbertson

IPC分类号： A61K47/54 ,  A61K47/60 ,  C07D209/34 ,  A61K31/404

摘要： The invention relates to (among other things) polymer-semaxanib moiety conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over the semaxanib moiety in unconjugated form.

公开(公告)号：US20170360948A1

公开(公告)日：2017-12-21

申请号：US15690106

申请日：2017-08-29

申请人： Nektar Therapeutics

发明人： Jennifer Riggs-Sauthier ,  Franco J. Duarte ,  Aaron S. Hammons

IPC分类号： A61K47/60

CPC分类号： A61K47/60

摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.

公开(公告)号：US20170189369A1

公开(公告)日：2017-07-06

申请号：US15296414

申请日：2016-10-18

申请人： Nektar Therapeutics

发明人： Antoni Kozlowski ,  Samuel P. McManus ,  Jennifer Riggs-Sauthier ,  Xiaoming Shen ,  Wen Zhang

IPC分类号： A61K31/337 ,  C08G65/333 ,  C08G65/332

CPC分类号： A61K31/337 ,  A61K31/4745 ,  A61K31/785 ,  A61K38/00 ,  A61K47/60 ,  C08G65/3328 ,  C08G65/33344 ,  C08G79/08

摘要： Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.