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    Secnidazole for use in the treatment of trichomoniasis
    2.
    发明授权
    Secnidazole for use in the treatment of trichomoniasis 有权

    公开(公告)号：US11000508B2

    公开(公告)日：2021-05-11

    申请号：US16901739

    申请日：2020-06-15

    申请人： LUPIN INC.

    发明人： Helen S. Pentikis ,  David Palling ,  Carol J. Braun ,  Richard Holl

    IPC分类号： A61K31/4164 ,  A61K45/06 ,  C07D233/94 ,  A61K31/565 ,  A61K31/567 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50

    摘要： Method of treating trichomoniasis in a subject in need thereof involving administering to the subject a therapeutically effective amount of secnidazole in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules having a volume-weighted particle size distribution within a microgranule population, wherein the volume-weighted particle size distribution as measured from a representative sample of the microgranule population comprises (a) at least 10% of the microgranule population having a volume-weighted particle size about no less than 470 micrometers; or (b) 50% of the microgranule population having a volume-weighted particle size between about no less than 640 micrometers and about no more than 810 micrometers; or (c) 90% of the microgranule population having a volume-weighted particle size about no more than 1170 micrometers; or (d) a combination thereof, which can include some or all of (a) through (c) above.

    ANTIMICROBIAL DRUG SYNTHESIS AND THERAPEUTIC COMPOSITIONS
    4.
    发明申请
    ANTIMICROBIAL DRUG SYNTHESIS AND THERAPEUTIC COMPOSITIONS 审中-公开

    公开(公告)号：US20180311214A1

    公开(公告)日：2018-11-01

    申请号：US15973939

    申请日：2018-05-08

    申请人： John Malcolm Hall Gregg

    发明人： John Malcolm Hall Gregg

    IPC分类号： A61K31/4164 ,  A61K9/00 ,  C07D233/94 ,  A61K45/06

    CPC分类号： A61K31/4164 ,  A61K9/0014 ,  A61K45/06 ,  C07D233/94

    摘要： This invention relates to the medical use of an antimicrobial agent, racemic Ornidazole, its (R) and (S) enantiomers, or pharmaceutically acceptable salts or esters thereof, and to methods of treatment which involve treating a subject with Ornidazole. The racemic (rac)-ornidazole, its enantiomers, or pharmaceutically acceptable salts or esters thereof, may be used in combination with other actives. The invention also relates to pharmaceutical formulations and compositions comprising (rac)-ornidazole, (R)-ornidazole, (S)-ornidazole, or pharmaceutically acceptable salts or esters thereof, and/or other actives as well as methods to stereoselectively manufacture the enantiomers.

    DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES
    8.
    发明申请
    DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES 审中-公开
    感染性疾病诊断剂

    公开(公告)号：US20120219500A1

    公开(公告)日：2012-08-30

    申请号：US13504318

    申请日：2010-10-25

    申请人： Kazuhisa Sakurai ,  Akio Nagano

    发明人： Kazuhisa Sakurai ,  Akio Nagano

    IPC分类号： A61K51/04 ,  G01N33/569 ,  C07F5/00 ,  C07D233/91 ,  C07D233/95 ,  C07D233/94 ,  A61K49/00

    CPC分类号： G01N33/52 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0463 ,  C12Q1/025 ,  C12Q1/18 ,  G01N33/569 ,  G01N2333/205 ,  G01N2333/35

    摘要： A diagnostic agent for infectious diseases which is capable of distinguishing among different kinds of bacterial species and which allows simple and non-invasive measurement and/or imaging in a short period of time is provided; and a screening method for a therapeutic agent for infectious diseases caused by microorganisms are provided.A diagnostic agent for infectious diseases caused by nitroimidazole susceptible microorganisms, containing an imidazole derivative or a fused imidazole derivative having at least one nitro group on an imidazole ring, or a labeled form thereof as an active ingredient is provided.

    摘要翻译： 提供能够区分不同种类的细菌种类并且允许在短时间内进行简单和非侵入性测量和/或成像的感染性疾病诊断剂; 并提供了由微生物引起的感染性疾病的治疗剂的筛选方法。 提供了由咪唑衍生物或咪唑环上具有至少一个硝基的稠合咪唑衍生物或其标记形式作为有效成分的由硝基咪唑易感微生物引起的感染性疾病的诊断剂。