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公开(公告)号：US06177478B1
公开(公告)日：2001-01-23
申请号：US09359226
申请日：1999-07-22
IPC分类号： A61K4700
CPC分类号： A61K45/06 , A61K31/785 , A61K31/787 , A61K38/44 , A61K38/51 , C12Y102/03004 , C12Y401/01002 , A61K2300/00
摘要： A method for reducing oxalate levels in a patient that includes administering to the patient a therapeutically effective amount of non-absorbable amine polymers such as a polymer characterized by a repeat unit having the formula: and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4.
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公开(公告)号：US5925379A
公开(公告)日：1999-07-20
申请号：US826197
申请日：1997-03-27
申请人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley , Thomas X. Neenan , George M. Whitesides
发明人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley , Thomas X. Neenan , George M. Whitesides
IPC分类号： A61K31/74 , A61K31/785 , A61K9/10 , A61K47/32
CPC分类号： A61K31/74 , A61K31/785 , Y10S514/824 , Y10S525/903
摘要： The present invention relates to a method for removing bile salts from a patient, comprising the step of administering to the patient a therapeutically effective amount of a polymer network composition comprising a cationic polymer. In one embodiment, the polymer network is an interpenetrating polymer network. In another embodiment, the polymer network is a semi-interpenetrating polymer network.
摘要翻译： 本发明涉及一种从患者中除去胆汁盐的方法，包括向患者施用治疗有效量的包含阳离子聚合物的聚合物网络组合物的步骤。 在一个实施方案中，聚合物网络是互穿聚合物网络。 在另一个实施方案中，聚合物网络是半互穿聚合物网络。
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公开(公告)号：US5919832A
公开(公告)日：1999-07-06
申请号：US779779
申请日：1997-01-07
IPC分类号： A61K31/785 , A61K31/787 , C08F8/00 , C08F8/02 , C08F8/32 , C08F8/44 , C08F220/34 , C08F220/60
CPC分类号： A61K31/785 , A61K31/787 , C08F220/34 , C08F220/60 , C08F8/00 , C08F8/02 , C08F8/44 , Y10S514/824
摘要： An amine polymer includes first and second substituents bound to amines of the polymer. The first substituent includes a hydrophobic moiety. The second substituent includes a quaternary amine-containing moiety. A method for binding bile salts of bile acids in a mammal includes orally administering to the mammal a therapeutically-effective amount of the amine polymer.
摘要翻译： 胺聚合物包括与聚合物的胺结合的第一和第二取代基。 第一取代基包括疏水部分。 第二取代基包括含季胺的部分。 在哺乳动物中结合胆汁酸胆汁的方法包括向哺乳动物口服给予治疗有效量的胺聚合物。
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84.发明授权Method for removing bile salts from a patient with alkylated amine polymers 失效从患有烷基化胺聚合物的患者中除去胆汁盐的方法
公开(公告)号：US5679717A
公开(公告)日：1997-10-21
申请号：US460980
申请日：1995-06-05
IPC分类号： A01N33/18 , A61K20060101 , A61K31/04 , A61K31/785 , A61K31/787 , A61P1/16 , A61P3/06 , C08F8/00 , C08F8/02 , C08F8/44 , C08F16/00 , C08F18/22 , C08F26/02 , C08F116/00 , C08F220/34 , C08F220/60 , C08F283/00 , C08G69/26 , C08G73/00 , C08G73/02 , C08G81/00
CPC分类号： C08F220/60 , A61K31/785 , A61K31/787 , C08F220/34 , C08F26/00 , C08F8/00 , C08F8/02 , C08F8/44 , C08L39/02
摘要： A method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of product produced by a process comprising alkylating one or more crosslinked amine polymers, salts or copolymers thereof with at least one alkylating agent. The reaction product is characterized in that: (i) at least some of the nitrogen atoms are unreacted with alkylating agent; and (ii) less than 10 mol% of the nitrogen atoms in the polymer react with the alkylating agent to form quaternary ammonium units.
摘要翻译： 一种从患者中除去胆汁盐的方法，包括向患者施用治疗有效量的通过包括将一种或多种交联胺聚合物，其盐或共聚物与至少一种烷化剂烷基化的方法产生的产物。 反应产物的特征在于：（i）至少一些氮原子与烷基化剂反应; 和（ii）聚合物中少于10摩尔％的氮原子与烷基化剂反应形成季铵单元。
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