公开(公告)号：US20080027063A1

公开(公告)日：2008-01-31

申请号：US11758243

申请日：2007-06-05

申请人： Lianyun Zhao ,  Panduranga Reddy ,  Neng-Yang Shih ,  Kamil Paruch ,  Timothy Guzi ,  M. Siddiqui

发明人： Lianyun Zhao ,  Panduranga Reddy ,  Neng-Yang Shih ,  Kamil Paruch ,  Timothy Guzi ,  M. Siddiqui

IPC分类号： A61K31/4985 ,  A61P35/00 ,  C07D487/04

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的咪唑并吡嗪化合物作为蛋白质和/或检查点激酶的抑制剂，制备此类化合物的方法，包含一种或多种此类化合物的药物组合物，制备药物制剂的方法，包括一种或多种 化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与蛋白质或检查点激酶相关的一种或多种疾病的方法。

公开(公告)号：US20070105864A1

公开(公告)日：2007-05-10

申请号：US11598188

申请日：2006-11-08

申请人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  David Parry ,  Lianyun Zhao ,  Patrick Curran ,  David Belanger ,  Blake Hamann ,  Panduranga Reddy ,  M. Siddiqui ,  Praveen Tadikonda

发明人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  David Parry ,  Lianyun Zhao ,  Patrick Curran ,  David Belanger ,  Blake Hamann ,  Panduranga Reddy ,  M. Siddiqui ,  Praveen Tadikonda

IPC分类号： A61K31/498

CPC分类号： A61K31/4985 ,  A61K31/498

摘要： The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

摘要翻译： 本发明提供使用咪唑并[1,2-a]吡嗪化合物抑制选自AKT，检查点激酶，极光激酶，Pim-1激酶和酪氨酸激酶的蛋白激酶的方法以及治疗，预防，抑制 ，或使用这些化合物改善与蛋白激酶相关的一种或多种疾病。

公开(公告)号：US20060106023A1

公开(公告)日：2006-05-18

申请号：US11272392

申请日：2005-11-10

申请人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Lianyun Zhao ,  Patrick Curran ,  David Belanger ,  Blake Hamann ,  Panduranga Reddy ,  M. Siddiqui

发明人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer ,  Lianyun Zhao ,  Patrick Curran ,  David Belanger ,  Blake Hamann ,  Panduranga Reddy ,  M. Siddiqui

IPC分类号： A61K31/506 ,  A61K31/498 ,  C07D487/02

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的咪唑并[1,2-a]吡嗪化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

公开(公告)号：US20060041131A1

公开(公告)日：2006-02-23

申请号：US11244772

申请日：2005-10-06

申请人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer

发明人： Timothy Guzi ,  Kamil Paruch ,  Michael Dwyer

IPC分类号： A61K31/519 ,  C07D487/04

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：US20050187219A1

公开(公告)日：2005-08-25

申请号：US11064044

申请日：2005-02-23

申请人： Timothy Guzi ,  Kamil Paruch

发明人： Timothy Guzi ,  Kamil Paruch

IPC分类号： A61K31/53 ,  C07D487/04

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the kinases using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]三嗪化合物作为激酶抑制剂，例如细胞周期蛋白依赖性激酶，制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物 化合物，制备包含一种或多种这样的化合物的药物制剂的方法，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与激酶相关的一种或多种疾病的方法。