公开(公告)号：US6152954A

公开(公告)日：2000-11-28

申请号：US121006

申请日：1998-07-22

申请人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

发明人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Qingsheng Zhu ,  Peter T. Kelley ,  David M. Flynn ,  John E. Heil

IPC分类号： A61N1/05

CPC分类号： A61N1/0573

摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.

摘要翻译： 一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。 引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。 引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。 第一和第二电极都适于定位和固定在墙上。 活性固定元件用作第二电极的一部分。 引线体还包括有助于第二电极的定位和固定的弯曲部分。 在另一个实施例中，主引线主体包括凹部，其中安装在一端的心房引线主体和主动固定元件可以从凹陷位置行进到用于固定到心脏壁的位置。 主动固定元件也可以通过转动端子销来移动。

公开(公告)号：US09370654B2

公开(公告)日：2016-06-21

申请号：US12360680

申请日：2009-01-27

申请人： Avram Scheiner ,  David E. Euler

发明人： Avram Scheiner ,  David E. Euler

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61B5/00

CPC分类号： A61N1/0556 ,  A61B5/4035 ,  A61B5/4047 ,  A61B5/7217 ,  A61N1/36114

摘要： An implantable medical device and associated method deliver a therapy to an autonomic nerve. The therapy delivery includes delivering therapeutic low frequency (LF) electrical stimulation pulses to the autonomic nerve and delivering a high frequency electrical signal to the autonomic nerve during the LF frequency stimulation pulse delivery. The high frequency stimulation signal blocks activation of autonomic nerve fibers innervating a non-targeted tissue during the therapeutic LF stimulation pulse delivery.

摘要翻译： 可植入医疗装置和相关方法将治疗递送至自主神经。 治疗递送包括在LF频率刺激脉冲传送期间向自主神经递送治疗性低频（LF）电刺激脉冲并将高频电信号传送到自主神经。 高频刺激信号阻止在治疗性LF刺激脉冲输送期间支配非目标组织的自主神经纤维的活化。

公开(公告)号：US08527045B2

公开(公告)日：2013-09-03

申请号：US12610149

申请日：2009-10-30

申请人： Paul G. Krause ,  Avram Scheiner

发明人： Paul G. Krause ,  Avram Scheiner

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36514 ,  A61N1/36521

摘要： An implantable medical system that includes a cardiac therapy module and a neurostimulation therapy module may identify when neurostimulation electrodes have migrated toward a patient's heart. In some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on a physiological response to an electrical signal delivered to the patient via the neurostimulation electrodes. In addition, in some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on an electrical cardiac signal sensed via the neurostimulation electrodes.

公开(公告)号：US08515535B2

公开(公告)日：2013-08-20

申请号：US12695895

申请日：2010-01-28

申请人： Donald L. Hopper ,  John M. Voegele ,  Jesse W. Hartley ,  Avram Scheiner

发明人： Donald L. Hopper ,  John M. Voegele ,  Jesse W. Hartley ,  Avram Scheiner

IPC分类号： A61N1/00

CPC分类号： A61B5/686 ,  A61B5/0022 ,  A61B5/0024 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/076 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/085 ,  A61B5/091 ,  A61B5/1118 ,  A61B5/4836 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/746 ,  A61B5/747 ,  A61N1/3627 ,  A61N1/36585 ,  A61N1/3702 ,  A61N1/3987 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30

摘要： Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.

公开(公告)号：US20130073000A1

公开(公告)日：2013-03-21

申请号：US13678048

申请日：2012-11-15

申请人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

发明人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

IPC分类号： A61N1/36 ,  A61N1/378

CPC分类号： A61N1/36117 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37288 ,  A61N1/3787

摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.

摘要翻译： 本主题的一个方面涉及可植入医疗装置。 该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。 神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。 控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。 本文提供了其他方面。

公开(公告)号：US08301234B2

公开(公告)日：2012-10-30

申请号：US13288105

申请日：2011-11-03

申请人： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/04

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US20120239099A1

公开(公告)日：2012-09-20

申请号：US13484060

申请日：2012-05-30

申请人： Ronald W. Heil, JR. ,  Avram Scheiner ,  Imad Libbus

发明人： Ronald W. Heil, JR. ,  Avram Scheiner ,  Imad Libbus

IPC分类号： A61N1/365 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

摘要翻译： 本主题的各个方面提供可植入医疗装置。 在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。

公开(公告)号：US20120209130A1

公开(公告)日：2012-08-16

申请号：US13456795

申请日：2012-04-26

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

IPC分类号： A61B5/0402 ,  A61B7/00

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

摘要翻译： 用于输出心音的装置包括可植入系统和外部系统。 可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。 外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。 可植入系统还可以包括用于检测心脏电信号的传感器。 在这种情况下，还输出表示心电信号的输出。

公开(公告)号：US20110022109A1

公开(公告)日：2011-01-27

申请号：US12893127

申请日：2010-09-29

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61N1/365 ,  A61N1/375

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US07747334B2

公开(公告)日：2010-06-29

申请号：US11277326

申请日：2006-03-23

申请人： Mark J. Bly ,  Brian D. Soltis ,  Bruce A. Tockman ,  Avram Scheiner

发明人： Mark J. Bly ,  Brian D. Soltis ,  Bruce A. Tockman ,  Avram Scheiner

IPC分类号： A61N1/372

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： A lead for sensing and pacing a left ventricle of the heart includes a lead body having a proximal portion and a distal portion, a lumen extending through the lead body, a conductor extending through the lead body from the proximal end to the distal end and an electrode disposed on the distal portion of the lead body and electrically coupled to the conductor. A distal tip of the lead body is continuously deflectable upon advancement and withdrawal of a stylet through the lumen at the distal portion to access a selected branch of the coronary sinus. The distal tip of the lead body may be offset before or after continuously deflecting the distal tip.

摘要翻译： 用于感测和起搏心脏左心室的引线包括具有近端部分和远端部分的引线体，延伸穿过引线主体的内腔，从近端延伸穿过引线主体到远端的导体，以及 电极，其设置在引线体的远端部分上并电耦合到导体。 引导体的远侧末端在通过远端部分的内腔前进和取出探针时可连续偏转，以进入冠状窦的选定分支。 引线体的远端可以在连续偏转远端之前或之后偏移。