公开(公告)号：US20210300755A1

公开(公告)日：2021-09-30

申请号：US17341016

申请日：2021-06-07

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: B82Y5/00 ,  A61K31/7105 ,  A61K9/00 ,  A61K9/19 ,  A61K31/7115

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20210038519A1

公开(公告)日：2021-02-11

申请号：US17003105

申请日：2020-08-26

Applicant: TRANSLATE BIO, INC.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: A61K9/127 ,  A61K38/44 ,  A61K47/28 ,  C12N15/11 ,  A61K48/00

Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.

公开(公告)号：US10702478B2

公开(公告)日：2020-07-07

申请号：US16452353

申请日：2019-06-25

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

IPC: A61K9/14 ,  A61K9/19 ,  C07D233/64 ,  A61K9/127 ,  C07C323/25 ,  C07C323/44 ,  C12N15/88 ,  A61K38/45 ,  A61K38/46 ,  A61K38/47 ,  A61K38/50 ,  A61K31/7088 ,  C07C323/27 ,  C07J41/00 ,  C07J43/00 ,  A61K9/51

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g. as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US10507249B2

公开(公告)日：2019-12-17

申请号：US16502672

申请日：2019-07-03

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  C12N9/64 ,  A61K38/45 ,  A61K9/00 ,  A61K31/713 ,  A61K9/51 ,  C12N9/40 ,  C07K14/505 ,  A61K9/127 ,  A61K38/48 ,  C12N15/85 ,  C12N15/52 ,  C07K14/81 ,  A61K38/18 ,  A61K38/47 ,  A61K38/57

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20190314284A1

公开(公告)日：2019-10-17

申请号：US16452353

申请日：2019-06-25

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

IPC: A61K9/19 ,  A61K31/7088 ,  C07D233/64 ,  C07J41/00 ,  C07C323/27 ,  C07J43/00 ,  A61K9/127 ,  C07C323/25 ,  C07C323/44 ,  C12N15/88 ,  A61K38/45 ,  A61K38/46 ,  A61K38/47 ,  A61K38/50

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g. as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US10413618B2

公开(公告)日：2019-09-17

申请号：US16233031

申请日：2018-12-26

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K31/713 ,  A61K9/00 ,  A61K9/127 ,  C07K14/505 ,  C07K14/81 ,  C12N9/40 ,  C12N9/64 ,  C12N15/52 ,  C12N15/85 ,  A61K9/51

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20190192689A1

公开(公告)日：2019-06-27

申请号：US16286400

申请日：2019-02-26

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  C12N9/64 ,  A61K9/51 ,  C12N15/85 ,  C12N15/52 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K31/713 ,  A61K9/00 ,  A61K9/127 ,  C07K14/505 ,  C07K14/81 ,  C12N9/40

CPC classification number: A61K48/0008 ,  A61K9/0019 ,  A61K9/0073 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/713 ,  A61K38/1816 ,  A61K38/47 ,  A61K38/4846 ,  A61K38/57 ,  A61K48/00 ,  A61K48/0075 ,  A61K48/0091 ,  C07K14/505 ,  C07K14/8125 ,  C12N9/2465 ,  C12N9/644 ,  C12N15/52 ,  C12N15/85 ,  C12Y302/01022 ,  C12Y304/21022

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20190192435A1

公开(公告)日：2019-06-27

申请号：US16182090

申请日：2018-11-06

Applicant: TRANSLATE BIO, INC.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: A61K9/127 ,  A61K38/44 ,  C12N15/11 ,  A61K47/28

Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.

公开(公告)号：US10238754B2

公开(公告)日：2019-03-26

申请号：US15482117

申请日：2017-04-07

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K9/00 ,  A61K9/51 ,  A61K31/713 ,  A61K9/127 ,  C07K14/505 ,  C07K14/81 ,  C12N9/40 ,  C12N9/64 ,  C12N15/52 ,  C12N15/85

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20180353616A1

公开(公告)日：2018-12-13

申请号：US15976813

申请日：2018-05-10

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  A61K47/28 ,  C12N15/88 ,  A61K47/14 ,  A61K47/24

CPC classification number: A61K48/0008 ,  A61K47/14 ,  A61K47/24 ,  A61K47/28 ,  C12N15/88

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.