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81.发明授权Method for the preparation of 4-alkylprolines and compounds produced thereby 失效制备4-烷基丙烯酸酯及其制备的化合物的方法
公开(公告)号：US3636043A
公开(公告)日：1972-01-18
申请号：US3636043D
申请日：1969-02-04
Applicant: UPJOHN CO
Inventor： MAGERLEIN BARNEY J
IPC: C07D207/16 , C07D207/22 , C07D207/24 , C07D27/04
CPC classification number: C07D207/22 , C07D207/16 , C07D207/24
Abstract: 4- ALKYLPROLINES ARE PREPARED IN TELATIVELY HIGH YIELDS BY REACTING A 2-ALKYLACROLEIN WITH A DIALKY N-ALKANOYLAMIDOMALONATE, DEHYDRATING THE OBTAINED 4-ALKYLPYRROLIDINE, AND THEREAFTER HYDROLYZING, DECARBOXYLATING, AND CATALYTICALLY HYDROGENATING THE PRODUCED 4-ALKYL-4-PYRROLINE. THE 4-ALKYL-PROLINES ARE USEFUL AS INTERMEDIATES FOR THE PREPARATION OF 4-ALKYL-PROLINES ARE USEFUL AS INTERMEDIATES FOR THE PREPARATION OF 4-ALKYLHYGRIC ACIDS WHICH, IN TURN, ARE A SOURCE OF COMPONENT ACIDS THAT ARE REACTED WITH AMINO SUGARS TO FORM ANTIBIOTICS OF THE LINCOMYCIN TYPE.
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公开(公告)号：US3509127A
公开(公告)日：1970-04-28
申请号：US3509127D
申请日：1968-04-30
Applicant: UPJOHN CO
Inventor： KAGAN FRED , MAGERLEIN BARNEY J
CPC classification number: C07H15/16 , C08G16/025 , C08G18/3857
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83.发明授权Oxygenated derivatives of methyl 6-amino-6, 8-dideoxy-1-thio-d-erythro-alpha-d-galacto-octopyranoside and ethyl 6-amino-6, 8-dideoxy-1-thio-d-erythro-alpha-d-galacto-octo-pyranoside and process for producing the same 失效6-氨基-6,8-二脱氧-1-硫代-D-赤-α-d-半乳糖 - 辛吡喃糖苷和6-氨基-6,8-二脱氧-1-硫代-D-赤藓酮甲酸的氧合衍生物 D-半乳糖 - 辛酰吡喃糖苷及其制备方法
公开(公告)号：US3382230A
公开(公告)日：1968-05-07
申请号：US56372066
申请日：1966-07-08
Applicant: UPJOHN CO
Inventor： MAGERLEIN BARNEY J
IPC: C07H15/16
CPC classification number: C07H15/16
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公开(公告)号：US3282957A
公开(公告)日：1966-11-01
申请号：US35948764
申请日：1964-04-13
Applicant: UPJOHN CO
Inventor： MAGERLEIN BARNEY J , BIRKENMEYER ROBERT D
IPC: C07D207/16
CPC classification number: C07D207/16 , Y10S514/944
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公开(公告)号：US3274212A
公开(公告)日：1966-09-20
申请号：US37530164
申请日：1964-06-15
Applicant: UPJOHN CO
Inventor： MAGERLEIN BARNEY J , BIRKENMEYER ROBERT D
IPC: A61K47/22 , C07D207/16 , C07D499/00
CPC classification number: A61K47/22 , C07D207/16 , C07D499/00 , Y10S514/944
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Patent Agency Ranking
公开(公告)号：US3210386A
公开(公告)日：1965-10-05
申请号：US8127061
申请日：1961-01-09
Applicant: UPJOHN CO
Inventor： BIRKENMEYER ROBERT D , FRED KAGAN , DANIEL LEDNICER , MAGERLEIN BARNEY J
IPC: A61K31/5685 , C07J41/00 , C07J75/00
CPC classification number: A61K31/5685 , C07J41/00 , C07J75/00
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公开(公告)号：US3027409A
公开(公告)日：1962-03-27
申请号：US73599858
申请日：1958-05-19
Applicant: UPJOHN CO
Inventor： HOGG JOHN A , MAGERLEIN BARNEY J
IPC: C07C49/21
CPC classification number: C07C49/21
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88.发明授权11beta-hydroxy-17alpha-alkyl estrogens and intermediates in the production thereof 失效11β-羟基-17α-烷基雌激素及其制备中间体
公开(公告)号：US2991295A
公开(公告)日：1961-07-04
申请号：US60544256
申请日：1956-08-21
Applicant: UPJOHN CO
Inventor： MAGERLEIN BARNEY J , HOGG JOHN A
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公开(公告)号：US2884420A
公开(公告)日：1959-04-28
申请号：US74059258
申请日：1958-06-09
Applicant: UPJOHN CO
Inventor： SPERO GEORGE B , MAGERLEIN BARNEY J , SCHNEIDER WILLIAM P , HOGG JOHN A
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公开(公告)号：US2880215A
公开(公告)日：1959-03-31
申请号：US61236556
申请日：1956-09-27
Applicant: UPJOHN CO
Inventor： FONKEN GUNTHER S , HOGG JOHN A , MAGERLEIN BARNEY J
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