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    BREAST CANCER RELATED GENE RQCD1
    81.
    发明申请
    BREAST CANCER RELATED GENE RQCD1 审中-公开
    乳腺癌相关基因RQCD1

    公开(公告)号：US20120022131A1

    公开(公告)日：2012-01-26

    申请号：US13060671

    申请日：2009-08-13

    申请人： Yusuke Nakamura ,  Toyomasa Katagiri ,  Akira Togashi

    发明人： Yusuke Nakamura ,  Toyomasa Katagiri ,  Akira Togashi

    IPC分类号： A61K31/713 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/574 ,  C12N15/113 ,  C12N15/63

    CPC分类号： G01N33/57415 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N2333/4703 ,  G01N2500/04

    摘要： The present invention provides methods for detecting and diagnosing cancer, such methods involving the determination of the expression level of the RQCD1, GIGYF1 or GIGYF2 genes. These genes were discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer and methods for treating cancer. Moreover, the present invention provides siRNAs targeting the RQCD1, GIGYF1 and/or GIGYF2 genes, all of which are suggested to be useful in the treatment of cancer.

    摘要翻译： 本发明提供了检测和诊断癌症的方法，所述方法涉及确定RQCD1，GIGYF1或GIGYF2基因的表达水平。 发现这些基因可以区别癌细胞与正常细胞。 此外，本发明提供筛选用于治疗癌症的治疗剂的方法和用于治疗癌症的方法。 此外，本发明提供靶向RQCD1，GIGYF1和/或GIGYF2基因的siRNA，所有这些都被认为可用于治疗癌症。

    DEVICE AND METHOD FOR AUTOMATICALLY PREPARING EMULSION DRUG
    83.
    发明申请
    DEVICE AND METHOD FOR AUTOMATICALLY PREPARING EMULSION DRUG 有权
    用于自动制备乳化剂的装置和方法

    公开(公告)号：US20110160700A1

    公开(公告)日：2011-06-30

    申请号：US13062501

    申请日：2009-09-07

    申请人： Yusuke Nakamura ,  Yuichi Iwai ,  Kouji Yoshida

    发明人： Yusuke Nakamura ,  Yuichi Iwai ,  Kouji Yoshida

    IPC分类号： A61M5/31

    CPC分类号： B01F3/0807 ,  A61G2203/34 ,  A61J1/20 ,  A61J3/00 ,  B01F5/0685 ,  B01F11/0071

    摘要： In preparation of an emulsion by causing a mixture to flow from one syringe through a connector into another syringe, an object is to prevent the air from being entrained into cylinders and prepare the emulsion containing no air bubble, and another object is to easily prepare a homogeneous emulsion. Provided is a syringe pressing apparatus, including: a syringe fixing mechanism for fixing two syringes to a casing, the two syringes being coupled to each other through a connector; a pressing mechanism for alternately pressing syringe plungers of the two syringes; and a plunger-pressure-measuring device for measuring a pressure with which the pressing mechanism presses the syringe plungers.

    摘要翻译： 在通过使混合物从一个注射器通过连接器流入另一个注射器来制备乳液时，目的是防止空气夹带到气缸中并且制备不含气泡的乳液，另一个目的是容易地制备 均匀乳液。 本发明提供一种注射器按压装置，包括：用于将两个注射器固定到壳体上的注射器固定机构，两个注射器通过连接器彼此连接; 用于交替地按压两个注射器的注射器柱塞的按压机构; 以及用于测量压力机构按压注射器柱塞的压力的柱塞压力测量装置。

    CANCER-RELATED GENES, CDCA5, EPHA7, STK31 AND WDHD1
    84.
    发明申请
    CANCER-RELATED GENES, CDCA5, EPHA7, STK31 AND WDHD1 审中-公开
    癌症相关基因，CDCA5，EPHA7，STK31和WDHD1

    公开(公告)号：US20110160280A1

    公开(公告)日：2011-06-30

    申请号：US12674659

    申请日：2008-08-21

    申请人： Yusuke Nakamura ,  Yataro Daigo ,  Shuichi Nakatsuru

    发明人： Yusuke Nakamura ,  Yataro Daigo ,  Shuichi Nakatsuru

    IPC分类号： A61K31/7052 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  C12Q1/68 ,  G01N33/68 ,  C12Q1/02 ,  G01N33/53 ,  A61P35/00

    CPC分类号： C12Q1/6886 ,  A61K31/70 ,  A61K48/00 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q2600/118 ,  C12Q2600/136

    摘要： The invention features methods for detecting cancers, especially lung cancer and/or esophageal cancer, using over-expressed gene; CDCA5, EPHA7, STK31 or WDHD1 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing cancers, based on the over-expression or the biological activity of CDCA5, EPHA7, STK31 or WDHD1 in the cancers, especially the interaction between EPHA7 and EGFR. Also, features are a method for treating cancers by administering a double-stranded molecule against CDCA5, EPHA7, STK31 or WDHD1 gene. The invention also features products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.

    摘要翻译： 本发明的特征在于使用过表达基因检测癌症，特别是肺癌和/或食管癌的方法; CDCA5，EPHA7，STK31或WDHD1比较正常器官。 还公开了基于癌症中CDCA5，EPHA7，STK31或WDHD1的过度表达或生物学活性，特别是EPHA7和EGFR之间的相互作用，鉴定用于治疗和预防癌症的化合物的方法。 此外，特征是通过对CDCA5，EPHA7，STK31或WDHD1基因施用双链分子来治疗癌症的方法。 本发明还包括产物，包括双链分子和编码它们的载体，以及包含所提供方法中有用的分子或载体的组合物。

    EBI3, DLX5, NPTX1 AND CDKN3 FOR TARGET GENES OF LUNG CANCER THERAPY AND DIAGNOSIS
    85.
    发明申请
    EBI3, DLX5, NPTX1 AND CDKN3 FOR TARGET GENES OF LUNG CANCER THERAPY AND DIAGNOSIS 审中-公开
    EBI3，DLX5，NPTX1和CDKN3用于肺癌治疗和诊断的靶基因

    公开(公告)号：US20110152345A1

    公开(公告)日：2011-06-23

    申请号：US12674759

    申请日：2008-08-21

    申请人： Yusuke Nakamura ,  Yataro Daigo ,  Shuichi Nakatsuru

    发明人： Yusuke Nakamura ,  Yataro Daigo ,  Shuichi Nakatsuru

    IPC分类号： A61K31/713 ,  C07H21/00 ,  C12N15/63 ,  C12Q1/68 ,  C12Q1/02 ,  G01N33/68 ,  G01N33/53 ,  C12Q1/42 ,  A61P35/00

    CPC分类号： A61K31/70 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4702 ,  C07K16/22 ,  C07K16/244 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/77 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  G01N33/57423 ,  G01N2800/54

    摘要： The present invention relates to methods for treating or preventing lung cancer by administering a double-stranded molecule against one or more of EBI3, DLX5, NPTX1, CDKN3 or EF-I delta genes or compositions, vectors or cells containing such a double-stranded molecule. The present invention also features methods for diagnosing lung cancer, especially NSCLC or SCLC, using one or more over-expressed genes selected from among EBI3, DLX5, NPTX1, CDKN3 and/or EF-I delta. Also disclosed are methods of identifying compounds for treating and preventing lung cancer, using as an index their effect on the over-expression of one or more of EBI3, DLX5, CDKN3 and/or EF-I delta in the lung cancer, the cell proliferation function of one or more of EBI3, DLX5, NPTX1, CDKN3 and/or EF-I delta or the interaction between CDKN3 and VRS, EF-I beta, EF-I gamma and/or EF-I delta.

    摘要翻译： 本发明涉及通过对EBI3，DLX5，NPTX1，CDKN3或EF-1δ基因中的一种或多种施用双链分子或组合物，载体或含有这种双链分子的细胞来治疗或预防肺癌的方法 。 本发明还涉及使用一种或多种选自EBI3，DLX5，NPTX1，CDKN3和/或EF-1δ的过度表达的基因来诊断肺癌，特别是NSCLC或SCLC的方法。 还公开了用于鉴定用于治疗和预防肺癌的化合物的方法，以其作为指标对肺癌中EBI3，DLX5，CDKN3和/或EF-1δ中的一种或多种的过表达的作用，细胞增殖 EBI3，DLX5，NPTX1，CDKN3和/或EF-1δ中的一种或多种的功能或CDKN3和VRS，EF-1β，EF-1γ和/或EF-1δ之间的相互作用。

    C2ORF18 AS TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS
    87.
    发明申请
    C2ORF18 AS TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
    C2ORF18作为靶基因治疗癌症和诊断

    公开(公告)号：US20110098339A1

    公开(公告)日：2011-04-28

    申请号：US12921766

    申请日：2009-03-10

    申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    IPC分类号： A61K31/713 ,  G01N33/68 ,  C07H21/00 ,  C12N15/63 ,  A61P35/00

    CPC分类号： G01N33/57438 ,  A61K48/005 ,  C07K16/303 ,  C12N15/113 ,  C12N2310/14 ,  G01N2500/02

    摘要： Described herein are objective methods for detecting or diagnosing a predisposition to developing cancer, particularly pancreatic cancer. In one embodiment, the diagnostic method involves the step of determining an expression level of C2orf18 using anti-C2orf18 antibody. The present invention further provides methods of screening for therapeutic agents useful in the treatment of a C2orf18-associated disease, such as a cancer, e.g. pancreatic cancer, methods of inhibiting the cell growth and treating or alleviating their symptom. The invention also features products, such as polynucleotides, polypeptides, and vectors double-stranded molecules, antibodies, vectors and compositions composed thereof.

    摘要翻译： 本文描述了用于检测或诊断发展中的癌症，特别是胰腺癌的易感性的客观方法。 在一个实施方案中，诊断方法包括使用抗C2orf18抗体确定C2orf18的表达水平的步骤。 本发明还提供筛选用于治疗C2orf18相关疾病（例如癌症）的治疗剂的方法。 胰腺癌，抑制细胞生长和治疗或缓解其症状的方法。 本发明还包括产物，例如多核苷酸，多肽和载体双链分子，抗体，载体和由其组成的组合物。

    Optical disk reproducing apparatus with a disk identifying function
    88.
    发明授权
    Optical disk reproducing apparatus with a disk identifying function 有权
    具有盘识别功能的光盘再现装置

    公开(公告)号：US07821888B2

    公开(公告)日：2010-10-26

    申请号：US11723798

    申请日：2007-03-22

    申请人： Yusuke Nakamura ,  Masakazu Ikeda ,  Toshifumi Takeuchi

    发明人： Yusuke Nakamura ,  Masakazu Ikeda ,  Toshifumi Takeuchi

    IPC分类号： G11B15/02

    CPC分类号： G11B19/125 ,  G11B20/1426 ,  G11B2020/1457

    摘要： An optical disk reproducing apparatus has a circuit for detecting a difference in modulation scheme between two types of optical disks in a reproduction signal and a circuit for determining the modulation schemes of the disks on the basis of the difference. Thus the apparatus can reproduce the two optical disks with use of the circuit which determines the modulation schemes of the disks to be reproduced.

    摘要翻译： 光盘再现装置具有用于检测再现信号中的两种类型的光盘之间的调制方式的差异的电路和用于基于该差确定盘的调制方案的电路。 因此，该装置可以使用确定要再现的盘的调制方案的电路再现两个光盘。