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公开(公告)号：US11407770B2
公开(公告)日：2022-08-09
申请号：US16475711
申请日：2018-01-05
发明人： Shengqian Ma , Feng-Shou Xiao , Qi Sun
摘要： A variety of amphiphobic porous materials are provided. The materials can include a variety of porous frameworks that have an outer surface functionalized by a plurality of perfluoroalkyl moieties. By careful selection of appropriate perfluoralkyl moieties, hydrophobic properties can be imparted to the exterior surface of the porous materials without significantly impacting the wetting properties of the porous interior. This can be used to create a variety of highly amphiphobic porous materials. Methods of making and using the amphiphobic porous materials are also provided.
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公开(公告)号：US20220241309A1
公开(公告)日：2022-08-04
申请号：US17722011
申请日：2022-04-15
发明人： Chad Dickey , Lindsey Shelton , Brian Blagg , John Koren , Laura Jenelle Blair
IPC分类号： A61K31/7048 , A61P25/28 , A61K31/366
摘要： Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.
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公开(公告)号：US20220222256A1
公开(公告)日：2022-07-14
申请号：US17601048
申请日：2020-04-03
发明人： Yicheng TU , Mehrad ESLAMI
IPC分类号： G06F16/2453 , G06F16/22 , G06F11/34
摘要： Disclosed are various embodiments for batched query processing and optimization in database management systems. A single algebraic expression is generated based at least in part on applying equivalence rules to algebraic expressions for a plurality of database queries of a database comprising a set of relations. The equivalence rules involve relational operators comprising Psi (ψ) operators. The database can be queried using a single database query to create a result that is equivalent to the plurality of database queries.
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公开(公告)号：US20220220167A1
公开(公告)日：2022-07-14
申请号：US17575080
申请日：2022-01-13
发明人： Chuanhai Cao , Jianfeng Cai
摘要： Provided herein are compounds, compositions, pharmaceutical compositions, kits, and methods relating to novel sulfono-γ-AA peptides. Novel sulfono-γ-AA peptides as described herein can have the structure according to Formula 1: In embodiments according to the present disclosure, novel sulfono-γ-AA peptides as described herein have minimal toxicity, can repair neuronal damage, inhibit Amyloid beta aggregation, and promote cellular growth and viability.
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公开(公告)号：US20220220153A1
公开(公告)日：2022-07-14
申请号：US17605219
申请日：2020-04-24
发明人： Jianfeng CAI , Peng SANG , Yan SHI , Haitao JI , Min ZHANG
摘要： Disclosed herein is a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). As disclosed herein, sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, and selectively disrupt β-catenin/BCL9 PPIs with even higher potency. More intriguingly, these sulfono-γ-AApeptides can enter cancer cells, bind with β-catenin and disrupt β-catenin/BCL PPI, and exhibit excellent cellular activity, which is much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies demonstrated the remarkable stability of the helical sulfono-γ-AApeptides, with no degradation in the presence of pronase for 24 h, augmenting their biological potential.
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公开(公告)号：US20220218635A1
公开(公告)日：2022-07-14
申请号：US17576375
申请日：2022-01-14
IPC分类号： A61K31/19 , A61P25/14 , A61K31/225 , A61K31/23 , A61K45/06 , A61K31/522 , A61K31/519
摘要： Disclosed are methods of treating seizures in a subject. The methods can include administering to the subject in need thereof an effective amount of uridine source and a ketogenic composition including a ketogenic compound.
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公开(公告)号：US20220204650A1
公开(公告)日：2022-06-30
申请号：US17498438
申请日：2021-10-11
摘要： In some embodiments, a bioelectronic device includes an electrode, target proteins, and attachment mechanisms that immobilize the target proteins on the electrode, the attachment mechanisms comprising linker proteins that interface with the target proteins and attach the target proteins to the electrode.
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公开(公告)号：US11332711B1
公开(公告)日：2022-05-17
申请号：US16376975
申请日：2019-04-05
摘要： Described herein are compositions and methods to cryopreserve sporozoites. In some aspects, the method can include the step of placing harvested salivary glands containing sporozoites into an insect-based medium.
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公开(公告)号：US11318304B2
公开(公告)日：2022-05-03
申请号：US15720322
申请日：2017-09-29
发明人： Mark Jeffrey Jaroszeski , Timothy Fawcett , Richard Jason Connolly , Andrew M. Hoff , Reginald Morley Atkins , Douglas Walter Brown , Richard A. Gilbert
摘要： The present invention provides a system and a method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. A result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize an electrical treatment for a particular target cell or cellular tissue.
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公开(公告)号：US20220126191A1
公开(公告)日：2022-04-28
申请号：US17511332
申请日：2021-10-26
发明人： KYLE REED , SEOK HUN KIM
摘要： A method, apparatus, or system for reducing gait asymmetry is disclosed. The method, apparatus, or system may include measuring one or more gait parameters of an individual; calculating a joint metric based on the measured one or more gait parameters; and signaling an adjustment of an amount of one or more perturbation techniques based on the joint metric for reducing asymmetry in a gait pattern of the individual. The one or more perturbation techniques include asymmetric rhythmic auditory cueing making a first audible cue with a first cue duration for one leg of the individual and a second audible cue with a second cue duration for another leg of the individual. Here, the first cue duration is different from the second cue duration. Other aspects, embodiments, and features are also claimed and described.
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