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    METHODS OF ACCELERATING MUSCLE GROWTH, DECREASING FAT DEPOSITS AND IMPROVING FEED EFFICIENCY IN LIVESTOCK ANIMALS
    5.
    发明申请
    METHODS OF ACCELERATING MUSCLE GROWTH, DECREASING FAT DEPOSITS AND IMPROVING FEED EFFICIENCY IN LIVESTOCK ANIMALS 有权
    促进肌肉生长，降低脂肪沉积和提高畜牧动物饲料效率的方法

    公开(公告)号：US20130090295A1

    公开(公告)日：2013-04-11

    申请号：US13689173

    申请日：2012-11-29

    申请人： BRIDGE PHARMA, INC.

    发明人： A.K. Gunnar Aberg

    IPC分类号： A61K31/137 ,  A61K31/7048

    CPC分类号： A61K31/137 ,  A61K31/138 ,  A61K31/7048

    摘要： A method of promoting or improving the feed efficiency and the muscle to fat ratio in animals by administering to the animals a therapeutically effective amount of a pure or substantially pure RR-isomer of ractopamine is disclosed. Also disclosed are animal feed preparations and compositions and pharmaceutical preparations capable of increasing lean meat deposition in an animal or decreasing body fat, or promoting or improving the growth of an animal or improving the feed efficiency of an animal. Feed preparation, compositions and pharmaceutical preparations including therapeutically effective amounts of a pure or substantially pure RR-isomer of ractopamine are disclosed.

    摘要翻译： 公开了一种通过向动物施用治疗有效量的纯赖碱或基本上纯的莱克多巴胺的RR-异构体来促进或改善动物的饲料效率和肌肉与脂肪比的方法。 还公开了能够增加动物中瘦肉沉积或减少体脂肪的动物饲料制剂和组合物和药物制剂，或促进或改善动物的生长或提高动物的饲料效率。 公开了饲料制备，组合物和药物制剂，包括治疗有效量的纯赖或基本上纯的莱克多巴胺的RR-异构体。

    Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain
    7.
    发明申请
    Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain 审中-公开
    茚满胺及其用途作为局部麻醉剂和慢性疼痛药物的制剂

    公开(公告)号：US20090137628A1

    公开(公告)日：2009-05-28

    申请号：US11991771

    申请日：2006-09-22

    申请人： A.K. Gunnar Aberg ,  Keith Johnson

    发明人： A.K. Gunnar Aberg ,  Keith Johnson

    IPC分类号： A61K31/4458 ,  A61P25/00

    CPC分类号： A61K9/12 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/02 ,  A61K9/7015

    摘要： Dermal and mucosal formulations of 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine, characterized by rapid dermal and mucosal absorption and long duration of therapeutic activity are provided. Also provided are solutions of 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine for injection, characterized by short onset time and long duration of activity. Formulations containing both 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine and capsaicin are also provided.

    摘要翻译： 提供2- [2-（N-苯基-N-2-二氢化茚基）氨基乙基]哌啶的皮肤和粘膜制剂，其特征在于快速皮肤和粘膜吸收和长时间的治疗活性。 还提供了用于注射的2- [2-（N-苯基-N-2-二氢化茚基）氨基乙基]哌啶的溶液，其特征在于起始时间短和活性持续时间长。 还提供含有2- [2-（N-苯基-N-2-二氢化茚基）氨基乙基]哌啶和辣椒素的制剂。

    Smooth muscle spasmolytic agents
    8.
    发明授权
    Smooth muscle spasmolytic agents 失效
    平滑肌解痉药

    公开(公告)号：US07141696B2

    公开(公告)日：2006-11-28

    申请号：US10850868

    申请日：2004-05-21

    申请人： A. K. Gunnar Aberg ,  Jan L. Chen ,  Andrew T. Maioli ,  George E. Wright

    发明人： A. K. Gunnar Aberg ,  Jan L. Chen ,  Andrew T. Maioli ,  George E. Wright

    IPC分类号： C07C211/03 ,  C07C211/04 ,  C07C211/05 ,  C07C211/06 ,  C07C211/07 ,  C07C211/08 ,  A61K31/135

    CPC分类号： C07C215/54

    摘要： The present invention relates to smooth muscle spasmolytic agents, pharmaceutical compositions containing them and method of using said compounds and compositions for the treatment of urinary incontinence, and other smooth muscle contractility conditions. More particularly, the present invention relates to certain metabolically stabilized secondary amines having smooth muscle relaxing properties while avoiding, on administration to a mammal, adverse side effects such as prominent antimuscarinic, arrhythmogenic and cardiodepressive effects.

    摘要翻译： 本发明涉及平滑肌解痉剂，含有它们的药物组合物和使用所述化合物和组合物治疗尿失禁的方法和其它平滑肌收缩状况。 更具体地说，本发明涉及具有平滑肌松弛特性的某些代谢稳定的仲胺，同时在给予哺乳动物时避免诸如突出的抗毒蕈碱性，致心律失常性和心脏抑制作用之类的副作用。

    Treatment of Dermal Cytokine Storm Syndromes
    10.
    发明申请
    Treatment of Dermal Cytokine Storm Syndromes 有权

    公开(公告)号：US20230000852A1

    公开(公告)日：2023-01-05

    申请号：US17851165

    申请日：2022-06-28

    申请人： Bridge Pharma, Inc.

    发明人： A.K. Gunnar Aberg ,  Kresimir Pucaj

    IPC分类号： A61K31/4535 ,  A61P29/00

    摘要： Described herein are methods of treating human and canine patients suffering from dermal Cytokine Storm syndromes related to dermal diseases such as atopic dermatitis, psoriasis or urticaria. A method of reducing the incidence and/or the intensity of a symptom of dermal hypercytokinemia in a patient suffering from an underlying dermal condition who develops the dermal hypercytokinemia as a consequence of the underlying dermal condition includes administering to the patient a therapeutically effective amount of norketotifen an isomer, an isomeric mixture, a prodrug or a pharmaceutically acceptable salt thereof. The symptom of dermal hypercytokinemia is an eruption of new dermal lesions accompanied by intense lesional and/or non-lesional pruritus.