公开(公告)号：US20170299495A1

公开(公告)日：2017-10-19

申请号：US15469111

申请日：2017-03-24

申请人： CE Biotechnology, Inc.

发明人： Chung-Er HUANG ,  Sheng-Wen CHEN ,  Hsin-Cheng HO ,  Ming CHEN

IPC分类号： G01N15/14 ,  G01N21/64 ,  G01N15/00

CPC分类号： G01N15/1484 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2400/0427 ,  G01N2015/1006

摘要： A biological particle capturing and retrieving system includes a capturing device including a substrate, an isolating layer and a driving unit, and a retrieving device including a micropipette. The isolating layer includes a top surface, multiple pores, and multiple fluidic grooves indented from the top surface, arranged in a herringbone pattern, and each having a bottom surface. The pores are formed in the bottom surfaces of the fluidic grooves, and each capture a biological particle in a liquid sample. The driving unit drives the liquid sample to flow by electrowetting through the pores. The micropipette has a carrier coated with a biological particle-binding material binding with the biological particle received in a corresponding pore.

公开(公告)号：US10730042B2

公开(公告)日：2020-08-04

申请号：US15861266

申请日：2018-01-03

申请人： CE Biotechnology, Inc.

发明人： Chung-Er Huang ,  Sheng-Wen Chen ,  Hsin-Cheng Ho ,  Wei-Cheng Hsu ,  Ming Chen

IPC分类号： B01L3/00 ,  G01N27/447 ,  G01N15/10 ,  G01N15/14 ,  G01N33/543 ,  B03C5/02 ,  B03C5/00

摘要： A biological detection system for detecting a liquid sample containing a plurality of target biological particles includes a capturing device including a cell structure, an inlet, an outlet, a monolithic chip, and a layer of binding agent. The monolithic chip includes a substrate and a plurality of discrete nano-sized structures which are displaced from each other and each of which extends uprightly from the substrate to terminate at a top end. The layer of binding agent is formed on the top end of each of the discrete nano-sized structures for capturing the target biological particles.

公开(公告)号：US20190001320A1

公开(公告)日：2019-01-03

申请号：US15861266

申请日：2018-01-03

申请人： CE Biotechnology, Inc.

发明人： Chung-Er Huang ,  Sheng-Wen Chen ,  Hsin-Cheng Ho ,  Wei-Cheng Hsu ,  Ming Chen

IPC分类号： B01L3/00 ,  G01N27/447 ,  B03C5/00 ,  G01N15/10

摘要： A biological detection system for detecting a liquid sample containing a plurality of target biological particles includes a capturing device including a cell structure, an inlet, an outlet, a monolithic chip, and a layer of binding agent. The monolithic chip includes a substrate and a plurality of discrete nano-sized structures which are displaced from each other and each of which extends uprightly from the substrate to terminate at a top end. The layer of binding agent is formed on the top end of each of the discrete nano-sized structures for capturing the target biological particles.