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公开(公告)号：US11839610B2
公开(公告)日：2023-12-12
申请号：US17806274
申请日：2022-06-10
发明人： Tsong-Long Hwang , Yu-Li Chen , Yu-Chia Chang
IPC分类号： A61K31/472 , A61P31/14 , C12N9/48 , A61K36/18
CPC分类号： A61K31/472 , A61K36/18 , A61P31/14 , C12N9/485 , C07K2319/30 , C12Y304/17023
摘要： A method for inhibiting infection of SARS-CoV-2 in a subject is provided, comprising administering an effective amount of plant extract, wherein the plant extract comprises an alcohol extract of the herbal of Menispermaceae, wherein the herbal of Menispermaceae is Stephania cepharantha or Stephania tetrandra.
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公开(公告)号：US10654848B1
公开(公告)日：2020-05-19
申请号：US16185017
申请日：2018-11-09
IPC分类号： C07D407/02 , C07D471/04 , A61P11/00 , C07D498/04 , A61P17/06
摘要： Disclosed herein are compounds of formula (I), and pharmaceutical compositions comprising the same. The compounds of formula (I) are neutrophilic inflammation inhibitors, thus, they are useful for treatment and/or prophylaxis of inflammatory diseases and/or disorders associated with abnormal activation of neutrophils, such as ARDS, ALI, COPD, lung fibrosis, chronic bronchitis, pulmonary emphysema, α-1 anti-trypsin deficiency, cystic fibrosis, idiopathic pulmonary fibrosis, liver injury, steatohepatitis, liver fibrosis, damages caused by ischemia and reperfusion, myocardial infarction, shock, stroke, and organ transplantation, ulcerative cholitis, vasculitis, SLE, sepsis, SIRS, arthritis, psoriasis, atopic dermatitis, and inflammatory skin diseases.
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3.发明公开公开(公告)号：US20240269220A1
公开(公告)日：2024-08-15
申请号：US18566993
申请日：2022-03-24
发明人： Tsong-Long HWANG , Yu-Chia CHANG , Wu-Dai-Yu JIANG
IPC分类号： A61K36/898 , A61K31/05 , A61K31/085 , A61K31/09
CPC分类号： A61K36/898 , A61K31/05 , A61K31/085 , A61K31/09
摘要： Disclosed herein is a method of treating diseases and/or disorders associated with the dysregulated activation and recruitment of neutrophils. The method includes administering to a subject in need thereof an effective amount of an extract of Bletilla formosana. The Bletilla formosana extract includes, at least, compounds of 3,3′-dihydroxy-5-methoxybibenzyl (Batatacin III), 9,10-dihydro-1-[(4-hydroxyphenyl)methyl]-4-methoxy-2,7-phenanthrenediol (Orchidble), 3′,5-dimethoxy-3-hydroxybibenzyl (BF8-4-2), 3,5-dimethoxy-3′-hydroxybibenzyl (BF8-4-3) and 3-hydroxy-5-methoxybibenzyl (BF8-4-4).
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公开(公告)号：US12028031B2
公开(公告)日：2024-07-02
申请号：US17503467
申请日：2021-10-18
发明人： Cher-Ming Tan , Vimal Kant Pandey
IPC分类号： H03F3/45
CPC分类号： H03F3/45076
摘要： The present invention is gallium nitride based operational amplifier because reliability and performance of the gallium nitride is better than the silicon counterpart in radiation environment. The operational amplifier includes four stages, first stage is dual input balanced output differential amplifier, second stage is dual input unbalanced differential amplifier, third stage is buffer stage to couple second and fourth stage, and fourth stage is cascaded common source amplifier with degeneration. A capacitor coupled between second and third stage is to enhance the stability of operational amplifier.
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公开(公告)号：US20240123017A1
公开(公告)日：2024-04-18
申请号：US18482014
申请日：2023-10-05
发明人： Tsong-Long Hwang , Yu-Chia Chang
IPC分类号： A61K36/898 , A61P17/02
CPC分类号： A61K36/898 , A61P17/02
摘要： A method for promoting chronic wound healing is provided, including administering an effective amount of Bletilla formosana (Hayata) Schltr. extract to a subject in need thereof, wherein the effective amount of Bletilla formosana (Hayata) Schltr. extract is 0.01 mg/kg-body weight to 100 mg/kg-body weight, and wherein the chronic wound including diabetic wound and Diabetic Foot Ulcer.
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公开(公告)号：US11517246B2
公开(公告)日：2022-12-06
申请号：US15923919
申请日：2018-03-16
申请人： Chang Gung University , Chang Gung Memorial Hospital, Linkou , Chang Gung Medical Foundation Chang Gung Memorial Hospital at Keelung
发明人： Jiun-Jie Wang , Yi-Hsin Weng , Shu-Hang Ng , Jur-Shan Cheng , Yi-Ming Wu , Yao-Liang Chen , Wey-Yil Lin , Chin-Song Lu , Wen-Chuin Hsu , Chia-Ling Chen , Yi-Chun Chen , Sung-Han Lin , Chih-Chien Tsai
摘要： Disclosed herein is a method for diagnosing a neurological disorder based on at least one magnetic resonance imaging (MRI) image. The method includes identifying brain image regions that contain a respective portion of diffusion index values of at least one diffusion index. For each of the brain image regions, a characteristic parameter based on the respective portion of the diffusion index values is calculated. a diagnoses is then made for the brain using one of predetermined categories of the neurological disorder by performing classification on a combination of the characteristic parameters via a classifier.
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公开(公告)号：US11452754B2
公开(公告)日：2022-09-27
申请号：US16785880
申请日：2020-02-10
发明人： Yi-Hong Wu , Yueh Hsiang Huang , Jong-Hwei Su Pang
IPC分类号： A61K36/71 , A61K36/25 , A61K36/076 , A61P3/06 , A61P3/10 , A61P3/04 , A61K36/894
摘要： Pharmaceutical compositions containing a combination of rhizoma coptidis and a herbal composition comprises at least one herb selected from the group consisting of Radix Ginseng, Poria, Rhizoma Atractylodis macrocephalae, Semen Lablab album, Rhizoma Dioscoreae, Embryo Nelumbinis, Radix Platycodonis, Semen Coicis, Fructus Amomi, Fructus Jujubae and Radix Glycyrrhizae are disclosed. Methods of treating diseases by administering an effective amount of the pharmaceutical composition are also provided.
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公开(公告)号：US11363968B2
公开(公告)日：2022-06-21
申请号：US15837872
申请日：2017-12-11
发明人： Ya-Ju Chang , Jiunn-Woei Liaw , Hung-Bin Chen
摘要： A center of pressure (CoP) based control system includes a sensing device and an electronic device connected to the sensing device. The sensing device includes sensors each of which continuously measures force exerted thereon by a subject and generates a sense signal based on a result of the measurement. The electronic device is connected to the sensing device, and receives the sense signals from the respective sensors, generates CoP data associated with a CoP trajectory based on the sense signals, determines whether a turning point exists in the CoP trajectory, generates an indication signal based on a result of the determination, and generates a control signal based on a direction of one of displacements of the CoP.
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公开(公告)号：US11351172B2
公开(公告)日：2022-06-07
申请号：US16793275
申请日：2020-02-18
发明人： Tsong-Long Hwang , Po-Jen Chen
IPC分类号： A61K31/519 , A61P11/00
摘要： The invention provides a pharmaceutical composition for treating phosphodiesterase 4-mediated (PDE4-mediated) disease in a patient and inhibition of phosphodiesterase 4 (PDE4) activity. The pharmaceutical composition includes an effective amount of Ribociclib and a pharmaceutically acceptable carrier. The invention further provides a use of the pharmaceutical composition for treating PDE4-mediated disease in a patient. The application of the pharmaceutical composition of the present invention and use thereof are advantageous for inhibiting of PDE4 activity and thus treating a PDE4-mediated disease.
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公开(公告)号：US11292012B2
公开(公告)日：2022-04-05
申请号：US16577765
申请日：2019-09-20
发明人： Min-Hsien Wu
摘要： A method for performing contactless ODEP for separation of CTCs is provided with the steps of obtaining patients' blood with rare cell suspected CTCs; adding at least one fluorescent antibody binding to CTCs into the blood; staining the blood; injecting the stained blood with fluorescent dye into an ODEP device and then performing fluorescent image identification; trapping the CTCs with at least one fluorescent antibody in the ODEP device by creating an image pattern and then generating an ODEP force; Separating the trapped CTCs from other non-CTCs cells; absorbing the trapped CTCs; and obtaining a high purity of CTCs. An apparatus for performing contactless ODEP for separation of CTCs is also provided.
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