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    IMMUNOSTIMULATORY DNA:RNA OLIGONUCLEOTIDES
    4.
    发明申请
    IMMUNOSTIMULATORY DNA:RNA OLIGONUCLEOTIDES 审中-公开
    免疫组化DNA：RNA寡核苷酸

    公开(公告)号：US20110300164A1

    公开(公告)日：2011-12-08

    申请号：US13053818

    申请日：2011-03-22

    申请人： Grayson B. Lipford ,  Alexandra Forsbach

    发明人： Grayson B. Lipford ,  Alexandra Forsbach

    IPC分类号： A61K39/00 ,  A61P37/04 ,  C07H21/04

    CPC分类号： A61K39/39 ,  A61K2039/55561

    摘要： Immunostimulatory sequence-specific RNA oligonucleotides corresponding to 3′ terminal sequences of single-stranded minus-sense RNA genomic RNAs are provided. Also provided are compositions and methods relating to an immunostimulatory 4-mer RNA motif provided as 5′-C/U-U-G/U-U-3′. Incorporation of this short RNA motif is sufficient to confer new and altered immunostimulatory properties in new and existing oligonucleotides, including CpG oligodeoxynucleotides. Also provided are methods for use of the immunostimulatory RNA oligonucleotides and DNA:RNA chimeric oligonucleotides of the invention to induce an immune response in vitro and in vivo, as well as to treat allergy, asthma, infection, and cancer in a subject. Single-stranded oligoribonucleotides of the invention are believed to signal through a Toll-like receptor (TLR) chosen from TLR9, TLR8, TLR7, and TLR3. The oligoribonucleotides can also be used in a method to screen for TLR antagonists.

    摘要翻译： 提供了对应于单链负义RNA基因组RNA的3'末端序列的免疫刺激序列特异性RNA寡核苷酸。 还提供了与作为5'-C / U-U-G-U-U-3'提供的免疫刺激性4聚体RNA基序相关的组合物和方法。 引入这种短RNA基序足以在新的和现有的寡核苷酸（包括CpG寡脱氧核苷酸）中赋予新的和改变的免疫刺激性质。 还提供了使用本发明的免疫刺激性RNA寡核苷酸和DNA：RNA嵌合寡核苷酸在体外和体内诱导免疫应答以及治疗受试者中的过敏，哮喘，感染和癌症的方法。 据信本发明的单链寡核糖核苷酸通过选自TLR9，TLR8，TLR7和TLR3的Toll样受体（TLR）发出信号。 寡核糖核苷酸也可用于筛选TLR拮抗剂的方法中。

    IMMUNOSTIMULATORY OLIGORIBONUCLEOTIDES
    5.
    发明申请
    IMMUNOSTIMULATORY OLIGORIBONUCLEOTIDES 有权
    免疫抑制剂寡核苷酸

    公开(公告)号：US20110206719A1

    公开(公告)日：2011-08-25

    申请号：US13046871

    申请日：2011-03-14

    申请人： Alexandra Forsbach ,  Jörg Vollmer ,  Grayson B. Lipford

    发明人： Alexandra Forsbach ,  Jörg Vollmer ,  Grayson B. Lipford

    IPC分类号： A61K39/385 ,  C07H21/02 ,  A61K31/7088 ,  A61K39/00 ,  A61P31/00 ,  A61P37/04

    CPC分类号： A61K39/39 ,  A61K31/7105 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

    摘要翻译： 本发明提供免疫刺激组合物和这些化合物在制备用于治疗疾病和体外用途的药物中的用途。 特别地，本发明的组合物包括掺入序列依赖性免疫刺激序列基序的免疫刺激性寡核糖核苷酸。 提供涉及磷酸键，核苷酸类似物，加合物及其组合的具体修饰。 任选地可以包括抗原的本发明的组合物可以单独使用或与其它治疗一起使用以刺激或增强免疫应答。 还提供了可用于治疗患有感染，癌症，过敏性疾病，哮喘，气道重塑或免疫缺陷的受试者的组合物和方法。 认为本发明的免疫刺激性寡核糖核苷酸可刺激Toll样受体8（TLR8）。

    Immunomodulatory Compositions, Combinations and Methods
    6.
    发明申请
    Immunomodulatory Compositions, Combinations and Methods 审中-公开
    免疫调节组合物，组合和方法

    公开(公告)号：US20110070575A1

    公开(公告)日：2011-03-24

    申请号：US11720862

    申请日：2005-12-08

    申请人： Keith B. Gorden ,  Xiaohong Qui ,  Paul D. Wightman

    发明人： Keith B. Gorden ,  Xiaohong Qui ,  Paul D. Wightman

    IPC分类号： A61K31/70 ,  C12N5/06 ,  A61P37/00

    CPC分类号： A61K45/06 ,  A61K31/437 ,  A61K31/7125 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/481 ,  A61K2300/00

    摘要： The invention provides immunomodulatory compositions, immunomodulatory combinations, and methods of modulating TLR7-mediated biological activity. Generally, the immunomodulatory compositions include an immunomodulatory oligonucleotide in an amount effective to reduce TLR7-mediated biological activity. In some cases, an immunomodulatory combination can further include an IRM compound. In some of these embodiments, the IRM compound can be a TLR7/8 agonist. Generally, the Imethods include contacting immune cells with an immunomodulatory composition in an amount effective to reduce TLR7-mediated biological activity.

    摘要翻译： 本发明提供免疫调节组合物，免疫调节组合和调节TLR7介导的生物活性的方法。 通常，免疫调节组合物包括有效降低TLR7介导的生物活性的量的免疫调节性寡核苷酸。 在一些情况下，免疫调节组合可进一步包括IRM化合物。 在这些实施方案的一些中，IRM化合物可以是TLR7 / 8激动剂。 通常，本发明包括使免疫细胞与有效降低TLR7介导的生物活性的量的免疫调节组合物接触。

    IMMUNOSTIMULATORY OLIGORIBONUCLEOTIDES
    7.
    发明申请
    IMMUNOSTIMULATORY OLIGORIBONUCLEOTIDES 审中-公开
    免疫抑制剂寡核苷酸

    公开(公告)号：US20100316659A1

    公开(公告)日：2010-12-16

    申请号：US12633963

    申请日：2009-12-09

    申请人： Alexandra Forsbach ,  Jörg Vollmer ,  Grayson B. Lipford

    发明人： Alexandra Forsbach ,  Jörg Vollmer ,  Grayson B. Lipford

    IPC分类号： A61K39/00 ,  C07H21/02 ,  A61K31/7105 ,  A61P37/02

    CPC分类号： A61K39/39 ,  A61K31/7105 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

    摘要翻译： 本发明提供免疫刺激组合物和这些化合物在制备用于治疗疾病和体外用途的药物中的用途。 特别地，本发明的组合物包括掺入序列依赖性免疫刺激序列基序的免疫刺激性寡核糖核苷酸。 提供涉及磷酸键，核苷酸类似物，加合物及其组合的具体修饰。 任选地可以包括抗原的本发明的组合物可以单独使用或与其它治疗一起使用以刺激或增强免疫应答。 还提供了可用于治疗患有感染，癌症，过敏性疾病，哮喘，气道重塑或免疫缺陷的受试者的组合物和方法。 认为本发明的免疫刺激性寡核糖核苷酸可刺激Toll样受体8（TLR8）。

    Immunostimulatory oligoribonucleotides
    8.
    发明授权
    Immunostimulatory oligoribonucleotides 有权
    免疫刺激寡核糖核苷酸

    公开(公告)号：US07662949B2

    公开(公告)日：2010-02-16

    申请号：US11603978

    申请日：2006-11-22

    申请人： Alexandra Forsbach ,  Jörg Vollmer ,  Grayson B. Lipford

    发明人： Alexandra Forsbach ,  Jörg Vollmer ,  Grayson B. Lipford

    IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K48/00 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K31/7105 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

    摘要翻译： 本发明提供免疫刺激组合物和这些化合物在制备用于治疗疾病和体外用途的药物中的用途。 特别地，本发明的组合物包括掺入序列依赖性免疫刺激序列基序的免疫刺激性寡核糖核苷酸。 提供涉及磷酸键，核苷酸类似物，加合物及其组合的具体修饰。 任选地可以包括抗原的本发明的组合物可以单独使用或与其它治疗一起使用以刺激或增强免疫应答。 还提供了可用于治疗患有感染，癌症，过敏性疾病，哮喘，气道重塑或免疫缺陷的受试者的组合物和方法。 认为本发明的免疫刺激性寡核糖核苷酸可刺激Toll样受体8（TLR8）。