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64 条记录 (耗时 0.039 秒)

    MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY
    6.
    发明申请
    MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY 审中-公开
    改良的寡核苷酸类似物与增强的免疫活性

    公开(公告)号：US20110244025A1

    公开(公告)日：2011-10-06

    申请号：US12946379

    申请日：2010-11-15

    申请人： Eugen Uhlmann ,  Arthur M. Krieg ,  Grayson B. Lipford

    发明人： Eugen Uhlmann ,  Arthur M. Krieg ,  Grayson B. Lipford

    IPC分类号： A61K9/127 ,  C07H21/02 ,  A61K39/00 ,  A61P11/00 ,  A61P31/14 ,  A61P35/00 ,  A61P37/08 ,  A61P37/04 ,  A61P11/06 ,  C12N5/02 ,  B82Y5/00

    CPC分类号： C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/3183 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2310/3529

    摘要： The invention provides immunostimulatory compositions and methods for their use. In particular, the immunostimulatory compositions of the invention include RNA-like polymers that incorporate an immunostimulatory sequence motif and at least one chemical modification to confer improved stability against nuclease degradation and improved activity. Specific modifications involving phosphate linkages, nucleotide analogs, and combinations thereof are provided. Compositions of the invention optionally include an antigen and can be used to stimulate an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an to allergic condition, or asthma. Modified oligoribonucleotide analogs of the invention are believed to stimulate Toll-like receptors TLR7 and TLR8.

    摘要翻译： 本发明提供免疫刺激组合物及其使用方法。 特别地，本发明的免疫刺激组合物包括纳入免疫刺激序列基序的RNA样聚合物和至少一种化学修饰，以提供改善的对核酸酶降解的稳定性和改善的活性。 提供了涉及磷酸键，核苷酸类似物及其组合的具体修饰。 本发明的组合物任选地包括抗原并且可以用于刺激免疫应答。 还提供了可用于治疗感染，癌症，过敏性疾病或哮喘的受试者的组合物和方法。 据信本发明的修饰的寡核糖核苷酸类似物刺激Toll样受体TLR7和TLR8。

    Combination motif immune stimulatory oligonucleotides with improved activity
    7.
    发明授权
    Combination motif immune stimulatory oligonucleotides with improved activity 失效
    具有改善活性的组合基序免疫刺激性寡核苷酸

    公开(公告)号：US08198251B2

    公开(公告)日：2012-06-12

    申请号：US12190402

    申请日：2008-08-12

    申请人： Jorg Vollmer ,  Eugen Uhlmann ,  Arthur M. Krieg ,  Douglas C. Hanson ,  Ulrike Samulowitz

    发明人： Jorg Vollmer ,  Eugen Uhlmann ,  Arthur M. Krieg ,  Douglas C. Hanson ,  Ulrike Samulowitz

    IPC分类号： A61K48/00

    CPC分类号： A61K31/7088 ,  A61K39/39 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/31 ,  C12N2310/315

    摘要： Immunostimulatory oligonucleotides, which contain a CpG immunostimulatory motif and a second motif that is capable of forming secondary structure, including duplex and higher order structures in vitro and in vivo, are disclosed. They include nucleic acids, or pharmaceutically acceptable salts thereof, having base sequences that include 5′ TCGTCGTTTTCGGCGCGCGCCGT 3′ (SEQ ID NO: 1), in which each C is unmethylated and 3′ refers to the 3′ end of the nucleic acid. The oligonucleotides activate B cells and NK cells and induce expression of type I interferon and interferon-γ. The oligonucleotides are useful for treating a variety of disorders and conditions, including allergy, asthma, infection, and cancer. In addition to their use as single agents and as combination therapies, the disclosed oligonucleotides are useful as adjuvants in vaccines.

    摘要翻译： 公开了含有CpG免疫刺激基序和能够形成二级结构的第二基序的免疫刺激性寡核苷酸，包括体外和体内的双链体和高级结构。 它们包括具有碱基序列的核酸或其药学上可接受的盐，其包含5'TCGTCGTTTTCGGCGCGCGCCGT 3'（SEQ ID NO：1），其中每个C是未甲基化的，3'是指核酸的3'末端。 寡核苷酸激活B细胞和NK细胞并诱导I型干扰素和干扰素-γ的表达。 寡核苷酸可用于治疗各种疾病和病症，包括过敏，哮喘，感染和癌症。 除了它们作为单一药剂和联合疗法的用途之外，所公开的寡核苷酸可用作疫苗中的佐剂。

    COMBINATION MOTIF IMMUNE STIMULATORY OLIGONUCLEOTIDES WITH IMPROVED ACTIVITY
    9.
    发明申请
    COMBINATION MOTIF IMMUNE STIMULATORY OLIGONUCLEOTIDES WITH IMPROVED ACTIVITY 失效
    具有改善活性的组合动物免疫刺激性寡核苷酸

    公开(公告)号：US20090087446A1

    公开(公告)日：2009-04-02

    申请号：US12190402

    申请日：2008-08-12

    申请人： JORG VOLLMER ,  Eugen Uhlmann ,  Arthur M. Krieg ,  Douglas C. Hanson ,  Ulrike Samulowitz

    发明人： JORG VOLLMER ,  Eugen Uhlmann ,  Arthur M. Krieg ,  Douglas C. Hanson ,  Ulrike Samulowitz

    IPC分类号： A61K39/00 ,  C07H21/00 ,  A61K39/02 ,  A61K39/002 ,  A61K39/12 ,  A61K31/7088

    CPC分类号： A61K31/7088 ,  A61K39/39 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/31 ,  C12N2310/315

    摘要： Immunostimulatory oligonucleotides, which contain a CpG immunostimulatory motif and a second motif that is capable of forming secondary structure, including duplex and higher order structures in vitro and in vivo, are disclosed. They include nucleic acids, or pharmaceutically acceptable salts thereof, having base sequences that include 5′ TCGTCGTTTTCGGCGCGCGCCGT 3′ (SEQ ID NO: 1), in which each C is unmethylated and 3′ refers to the 3′ end of the nucleic acid. The oligonucleotides activate B cells and NK cells and induce expression of type I interferon and interferon-γ. The oligonucleotides are useful for treating a variety of disorders and conditions, including allergy, asthma, infection, and cancer. In addition to their use as single agents and as combination therapies, the disclosed oligonucleotides are useful as adjuvants in vaccines.

    摘要翻译： 公开了含有CpG免疫刺激基序和能够形成二级结构的第二基序的免疫刺激性寡核苷酸，包括体外和体内的双链体和高级结构。 它们包括具有碱基序列的核酸或其药学上可接受的盐，其包含5'TCGTCGTTTTCGGCGCGCGCCGT 3'（SEQ ID NO：1），其中每个C是未甲基化的，3'是指核酸的3'末端。 寡核苷酸激活B细胞和NK细胞并诱导I型干扰素和干扰素-γ的表达。 寡核苷酸可用于治疗各种疾病和病症，包括过敏，哮喘，感染和癌症。 除了它们作为单一药剂和联合疗法的用途之外，所公开的寡核苷酸可用作疫苗中的佐剂。