-
公开(公告)号：US11617745B2
公开(公告)日：2023-04-04
申请号：US16544795
申请日：2019-08-19
摘要： Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
-
公开(公告)号：US20220127568A1
公开(公告)日：2022-04-28
申请号：US17429274
申请日：2020-02-07
发明人： Will MCLEAN , Megan HARRISON , Melissa HILL-DRZEWI , Bradley TAIT
IPC分类号： C12N5/071 , C12N5/0797 , A61K45/06 , A61P27/16
摘要： Provided are compositions and methods comprising an epigenetic agent and a Wnt agonist for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating inner ear hearing or balance disorders.
-
公开(公告)号：US20220096639A1
公开(公告)日：2022-03-31
申请号：US17492131
申请日：2021-10-01
IPC分类号： A61K47/34 , A61K47/12 , A61K31/506 , A61K31/4439 , A61K31/551 , A61K9/00
摘要： The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
-
公开(公告)号：US10016507B2
公开(公告)日：2018-07-10
申请号：US15448363
申请日：2017-03-02
IPC分类号： A61K47/34 , A61K31/5517 , A61K9/00 , A61K45/06 , A61K31/19
CPC分类号： A61K47/34 , A61K9/0046 , A61K31/19 , A61K31/5517 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
-
公开(公告)号：US20220192984A1
公开(公告)日：2022-06-23
申请号：US17282069
申请日：2019-10-02
发明人： Will MCLEAN , Rajesh MANCHANDA , Snehal KHEDKAR , Richard A. STRONG, Jr. , Ashley BANKS , Bradley TAIT , Christopher LOOSE
摘要： The present disclosure relates to pharmaceutical compositions (e.g., pre-lyophilized pharmaceutical compositions, lyophilized pharmaceutical compositions, and reconstituted solutions) comprising one or more otic therapeutic agents. The present disclosure also relates to methods of preparing the pharmaceutical compositions, and methods of using the pharmaceutical compositions for therapeutic purpose.
-
公开(公告)号：US11162071B2
公开(公告)日：2021-11-02
申请号：US16544792
申请日：2019-08-19
发明人： Christopher Loose , Will McLean , Megan Harrison
IPC分类号： A61K31/47 , C12N5/071 , A61K31/4375 , A61K31/472 , A61K31/506 , A61K38/10
摘要： Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
-
公开(公告)号：US10201540B2
公开(公告)日：2019-02-12
申请号：US15448419
申请日：2017-03-02
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/19 , A61K45/06 , A61K47/10 , A61K9/00 , A61K9/10 , A61K9/06 , A61L27/18 , A61L27/38
摘要： The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
-
公开(公告)号：US20220259559A1
公开(公告)日：2022-08-18
申请号：US17484658
申请日：2021-09-24
IPC分类号： C12N5/071 , A61K31/4375 , A61K31/47 , A61K31/472 , A61K31/506 , A61K38/10
摘要： Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
-
公开(公告)号：US20220160664A1
公开(公告)日：2022-05-26
申请号：US17429153
申请日：2020-02-07
发明人： Will MCLEAN , Megan S. HARRISON , Bradley TAIT
IPC分类号： A61K31/19 , A61K31/5377 , A61K31/444 , A61K31/4545 , A61K38/17 , A61K31/4725 , A61K31/443 , A61K31/4439 , A61K31/496 , A61K31/4409 , A61K31/195 , A61K31/495 , A61K31/4465 , A61K31/135 , A61K31/15 , A61K31/7064 , A61K31/7076 , A61K31/5517 , A61K31/506 , A61P27/16
摘要： Provided are compositions and methods comprising a TAZ activator and a Wnt agonist for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating inner ear hearing or balance disorders.
-
公开(公告)号：US20210260061A1
公开(公告)日：2021-08-26
申请号：US17317972
申请日：2021-05-12
IPC分类号： A61K31/506 , A61K31/19 , A61K45/06 , A61K47/10 , A61K9/00 , A61K9/10 , A61K9/06 , A61L27/18 , A61L27/38
摘要： The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.016 秒)
