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公开(公告)号:US20230058189A1
公开(公告)日:2023-02-23
申请号:US17429091
申请日:2020-02-07
发明人: Bradley TAIT , Megan S. HARRISON , Will MCLEAN
IPC分类号: C07D215/56 , C07D237/28 , A61P27/16 , C07D401/04
摘要: The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
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公开(公告)号:US20220259559A1
公开(公告)日:2022-08-18
申请号:US17484658
申请日:2021-09-24
IPC分类号: C12N5/071 , A61K31/4375 , A61K31/47 , A61K31/472 , A61K31/506 , A61K38/10
摘要: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
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公开(公告)号:US20220160664A1
公开(公告)日:2022-05-26
申请号:US17429153
申请日:2020-02-07
发明人: Will MCLEAN , Megan S. HARRISON , Bradley TAIT
IPC分类号: A61K31/19 , A61K31/5377 , A61K31/444 , A61K31/4545 , A61K38/17 , A61K31/4725 , A61K31/443 , A61K31/4439 , A61K31/496 , A61K31/4409 , A61K31/195 , A61K31/495 , A61K31/4465 , A61K31/135 , A61K31/15 , A61K31/7064 , A61K31/7076 , A61K31/5517 , A61K31/506 , A61P27/16
摘要: Provided are compositions and methods comprising a TAZ activator and a Wnt agonist for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating inner ear hearing or balance disorders.
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公开(公告)号:US20210260061A1
公开(公告)日:2021-08-26
申请号:US17317972
申请日:2021-05-12
IPC分类号: A61K31/506 , A61K31/19 , A61K45/06 , A61K47/10 , A61K9/00 , A61K9/10 , A61K9/06 , A61L27/18 , A61L27/38
摘要: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
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