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12 条记录 (耗时 0.016 秒)

    Novel antimicrobial bolisin peptides
    3.
    发明申请
    Novel antimicrobial bolisin peptides 审中-公开
    新型抗菌油松肽多肽

    公开(公告)号：US20090149391A1

    公开(公告)日：2009-06-11

    申请号：US12289180

    申请日：2008-10-22

    申请人： Cornelia Liepke ,  Susann Baxmann ,  Knut Adermann

    发明人： Cornelia Liepke ,  Susann Baxmann ,  Knut Adermann

    IPC分类号： A61K38/10 ,  C07K7/08 ,  C12P21/00 ,  A61P31/04

    CPC分类号： C07K7/08

    摘要： The invention relates to antibiotically effective peptides which are prepared for medical and commercial use by using biotechnological methods and chemical synthesis. The antibiotically effective peptides can be used in a suitable galenic formulation as medicaments/animal medicaments, food additives or as preservatives for the prevention of microbial contaminations of cosmetics, medical products and requisites.

    摘要翻译： 本发明涉及通过使用生物技术方法和化学合成制备用于医疗和商业用途的抗生素有效的肽。 抗生素有效的肽可以用作合适的盖仑制剂作为药物/动物药物，食品添加剂或防腐剂用于防止化妆品，医疗产品和必需品的微生物污染。

    Antimicrobial bolisin peptides
    5.
    发明授权
    Antimicrobial bolisin peptides 失效
    抗生素玻璃糖肽

    公开(公告)号：US07449545B2

    公开(公告)日：2008-11-11

    申请号：US10497909

    申请日：2002-12-04

    申请人： Cornelia Liepke ,  Susann Baxmann ,  Knut Adermann

    发明人： Cornelia Liepke ,  Susann Baxmann ,  Knut Adermann

    IPC分类号： A61K38/00

    CPC分类号： C07K7/08

    摘要： The invention relates to antibiotically effective peptides which are prepared for medical and commercial use by using biotechnological methods and chemical synthesis. The antibiotically effective peptides can be used in a suitable galenic formulation as medicaments/animal medicaments, food additives or as preservatives for the prevention of microbial contaminations of cosmetics, medical products and requisites.

    摘要翻译： 本发明涉及通过使用生物技术方法和化学合成制备用于医疗和商业用途的抗生素有效的肽。 抗生素有效的肽可以用作合适的盖仑制剂作为药物/动物药物，食品添加剂或防腐剂用于防止化妆品，医疗产品和必需品的微生物污染。

    Peptides and their use for the treatment of HIV infections
    9.
    发明授权
    Peptides and their use for the treatment of HIV infections 失效

    公开(公告)号：US07655629B2

    公开(公告)日：2010-02-02

    申请号：US10539627

    申请日：2003-12-19

    申请人： Knut Adermann ,  Frank Kirchhoff ,  Jan Münch ,  Axel Schulz

    发明人： Knut Adermann ,  Frank Kirchhoff ,  Jan Münch ,  Axel Schulz

    IPC分类号： A61K38/00 ,  A61K38/04 ,  A61K51/00 ,  A61M36/14 ,  C12Q1/70

    CPC分类号： C07K7/08

    摘要： The invention relates to peptides with biological activity against infection having the amino acid sequence Z1-LE-X1-IP-X2-X3-X4-P-X5-X6-X7-X8-X9-X10-K-X11-X12-X13-X14-X15-Z2, wherein X1 is a lysine, alanine, or aspartic acid; X2 is a cysteine, methionine or isoleucine; X3 is a serine, cysteine, lysine or glycine; X4 is an isoleucine, alanine, phenylalanine or cysteine; X5 is a proline, D-proline or a substituted L- or D-proline; X6 is a cysteine or glutamic acid; X7 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X8 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X9 is an amino acid with an aromatic side chain; X10 is a glycine, alanine or asparagine; X11 is a proline, aspartic acid, octahydroindolyl-2-carboxylic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X12 is a phenylalanine, alanine, glycine, glutamic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X13 is an amino acid with a hydrophobic or an aromatic side chain; X14 is an amino acid with a hydrophobic or an aromatic side chain; X15 is a phenylalanine or deletion; Z1 is NH2 or a sequence of 1 to 10 amino acid residues; Z2 is COOH or a sequence of 1 to 10 amino acid residues; and peptides which are fragments and/or covalently linked oligomers and/or derivatives, especially amidated, alkylated, acylated, sulfated, pegylated, phosphorylated and/or glycosylated derivatives, and mutants thereof, and with the provisio that (a) if X12 is alanine, glycine, glutamic acid, or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid than X13, X14 and X15 are phenylalanine, valine and phenylalanine respectively; and/or (b) if X12 is phenylalanine, than X13, X14 and X15 are valine, phenylalanine and a deletion, respectively; and (c) that there are at maximum two cysteine residues in a peptide.