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公开(公告)号：US20240159630A1
公开(公告)日：2024-05-16
申请号：US18281008
申请日：2022-03-10
摘要： The invention relates to a method for tissue processing of at least one biological tissue (105), comprising processing the at least one tissue (105) using at least one fluid (110, 120, 130, 140), determining a concentration change rate in the at least one fluid (110, 120, 130, 140), and performing a measure depending on the determined concentration change rate. Further, a corresponding tissue processor (100) is proposed.
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公开(公告)号：US11644392B2
公开(公告)日：2023-05-09
申请号：US16930417
申请日：2020-07-16
CPC分类号： G01N1/06 , G01N1/2813 , G01N35/00732 , G01N2001/282
摘要： The invention relates to an arrangement having a specimen plate (1) for freezing on a sample for processing in a microtome, which has an upper side (4) for freezing on the sample and a lower side (5), and having a transparent marking frame (6), having opaque regions forming a marking, which is arranged on the specimen plate (1); and to a method for assigning a sample after freezing onto that specimen plate; and to a method for identifying a sample that is frozen onto that specimen plate (1), the marking frame being arranged on the lower side (5) of the specimen plate (1) or so as to fit around the specimen plate (1).
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公开(公告)号：US20230076711A1
公开(公告)日：2023-03-09
申请号：US17793441
申请日：2021-01-19
发明人： ZheGuang FAN
摘要： The present disclosure relates to a cutter holder for a microtome. The cutter holder includes: a base; a pressing plate pivotably mounted to the base and having a first end configured to clamp the cutter; an eccentric shaft rotatably mounted in the base; and a sliding assembly slidably mounted in the base. The sliding assembly is arranged between the pressing plate and the eccentric shaft and is in contact with the eccentric shaft, and the sliding assembly is movable towards the pressing plate when the eccentric shaft rotates, so as to force the first end of the pressing plate to clamp the cutter with the base. The cutter holder according to embodiments of the present disclosure allows easy mounting and replacement of the pressing plate, facilitates clamping of the cutter and regulation of a clamping force, and has high working efficiency and high reliability.
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公开(公告)号：US20220390331A1
公开(公告)日：2022-12-08
申请号：US17775058
申请日：2019-11-07
发明人： Zheguang FAN
摘要： The present disclosure provides a blade load mechanism for a blade holder of a microtome. The blade holder has a base defining a blade receptacle configured to receive a blade, the blade load mechanism includes a blade supply container configured to contain a blade therein, the blade supply container defining a removal opening through which the blade is able to be removed from the blade supply container, and a blade access slot through an outer wall of the blade supply container in a length direction of the blade; and a blade pusher configured to engage with the blade through the blade access slot and slide along the blade access slot to push the blade out of the blade supply container through the removal opening, and deliver the blade into the blade receptacle. The present disclosure further provides a blade unload mechanism and a blade changing system.
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公开(公告)号：US20220170832A1
公开(公告)日：2022-06-02
申请号：US17673176
申请日：2022-02-16
发明人： Benjamin SIEHL , Markus SHARPE , Markus WITTMANN
摘要： A system having a first automatic machine (1) for processing or investigating biological samples and a second automatic machine (16) for processing or investigating biological samples. The first machine (1) and the second machine (16) are electrically connected to an electrical power grid in order to be supplied with electrical energy as an electrical load. The first machine (1) has a first control apparatus (13) and the second machine (16) has a second control apparatus (19), which detect disruptions in the supply of electrical energy from the power grid and, in the event of a disruption, switch over to a withdrawal of electrical energy from a first energy reservoir (12) or a second energy reservoir (18). The first machine (1) and the second machine (16) are also electrically connected to each other, such that the electrical energy is transferrable from an energy store of one of the automatic machines to the other automatic machine.
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公开(公告)号：US11280709B2
公开(公告)日：2022-03-22
申请号：US16626371
申请日：2019-02-25
发明人： Benjamin Siehl , Markus Sharpe , Markus Wittmann
摘要： A coverslipping machine (1) is embodied to be connected to an electrical power grid in order to be supplied with electrical energy as an electrical load; and removes specimen slides (4), having samples present thereon, from a specimen slide magazine (5) and respectively carries out a coverslipping process in which a mounting medium (7) and then a coverslip (8) are applied onto each specimen slide (4); and deposits the coverslipped specimen slides (4) in the specimen slide magazine (5) or in a further specimen slide magazine (55). The coverslipping machine (1) has an electrical energy reservoir (12) and an electronic control apparatus (13). The electronic control apparatus (13) detects disruptions in the supply of electrical energy from the power grid and, in the event of a disruption, switches over to a withdrawal of electrical energy from the electrical energy reservoir (12), and carries out a safety routine that includes at least the safety steps of completing the coverslipping of specimen slides (4) already equipped with the mounting medium (7), and then depositing them in the specimen slide magazine (5) or in the further specimen slide magazine (55).
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公开(公告)号：US20210025793A1
公开(公告)日：2021-01-28
申请号：US16930417
申请日：2020-07-16
摘要： The invention relates to an arrangement having a specimen plate (1) for freezing on a sample for processing in a microtome, which has an upper side (4) for freezing on the sample and a lower side (5), and having a transparent marking frame (6), having opaque regions forming a marking, which is arranged on the specimen plate (1); and to a method for assigning a sample after freezing onto that specimen plate; and to a method for identifying a sample that is frozen onto that specimen plate (1), the marking frame being arranged on the lower side (5) of the specimen plate (1) or so as to fit around the specimen plate (1).
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公开(公告)号：US10481054B2
公开(公告)日：2019-11-19
申请号：US15254211
申请日：2016-09-01
发明人： Florian Böhl , Ralf Eckert , Karin Flieger , Markus Berberich , Hermann Ulbrich , Stella Knorr , Andrew Guy
IPC分类号： G01N1/36
摘要： The invention relates to a method for embedding a tissue sample into an embedding medium. In a first step the tissue sample is held in an intended orientation in a container by means of a holding element that presses the tissue sample against a base of the container. In a further step a liquid embedding medium that has a temperature above 64 degrees Celsius, in particular in the range from 65 degrees Celsius to 67 degrees Celsius, or a temperature of 66 degrees Celsius, is poured into the container, and the base of the container is cooled. In a further step a separating motion is executed by way of which the tissue sample and the holding element move away from each other, those layers of the embedding medium through which the holding element moves during the separating motion having, during the separating motion, temperatures in the range from 54 degrees Celsius to 64 degrees Celsius, in particular of 60 degrees Celsius, and/or those portions of the embedding medium which are directly adjacent to the holding element having, during the separating motion, a temperature in the range from 54 degrees Celsius to 64 degrees Celsius, in particular of 60 degrees Celsius.
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公开(公告)号：US10345203B2
公开(公告)日：2019-07-09
申请号：US15091653
申请日：2016-04-06
发明人： Stella Knorr , Andrew Guy , Ralf Eckert , Fiona Tarbet , Fernando Dias , Chris Ryan , Neil Sanut
摘要： An apparatus for holding a tissue sample including a retaining member having a first tissue engaging surface and at least one biasing element, the first tissue engaging surface being moveably attached to the retaining member by said biasing element; and a base having a second tissue engaging surface and configured to engage the retaining member to form an interior area with the first and second tissue engaging surfaces facing each other, wherein the at least one biasing element urges the first tissue engaging surface toward the second tissue engaging surface to retain the tissue sample therebetween in the interior area.
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