公开(公告)号：US20240361208A1

公开(公告)日：2024-10-31

申请号：US18580949

申请日：2022-07-20

Applicant: PFM MEDICAL AG

Inventor： Steffen KRAUS ,  Erwin SCHNEIDER

IPC: G01N1/06 ,  G01N1/34

CPC classification number: G01N1/06 ,  G01N1/34 ,  G01N2001/061

Abstract: A device for collecting and sucking off clippings, in particular embedding medium, for example paraffin, on a microtome (1), in particular a rotary microtome, having at least one connecting element (12) for form-fitting and/or force-fitting attachment to the microtome (1) and a collecting tray (3) forming a collecting area, wherein an suction opening (4) for sucking off the clippings is formed on the collecting tray (3). Furthermore, a system with such a device, a microtome (1) and a work table (2) is disclosed.

公开(公告)号：US20240183763A1

公开(公告)日：2024-06-06

申请号：US18443049

申请日：2024-02-15

Applicant: Agilent Technologies, Inc.

Inventor： Kyle Schleifer ,  Kristin Briana Bernick ,  Adrienne Mccampbell ,  Nicholas M. Sampas ,  Victor Lim

IPC: G01N1/30 ,  G01N1/06 ,  G01N1/28 ,  G01N35/00 ,  G06T7/00

CPC classification number: G01N1/30 ,  G01N1/06 ,  G01N1/286 ,  G01N35/00594 ,  G06T7/0012 ,  G01N2001/068 ,  G01N2001/2873 ,  G06T2207/10064 ,  G06T2207/10152 ,  G06T2207/30024

Abstract: The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or location of the tissue in the embedded sample.

公开(公告)号：US20240167917A1

公开(公告)日：2024-05-23

申请号：US18384299

申请日：2023-10-26

Applicant: Clarapath, Inc.

Inventor： Partha P. Mitra ,  Charles R. Cantor ,  Baris Yagci ,  Steven Smith

IPC: G01N1/06 ,  G01N1/31 ,  G02B21/06 ,  G02B21/26 ,  G02B21/36 ,  G06T7/00

CPC classification number: G01N1/06 ,  G01N1/312 ,  G02B21/06 ,  G02B21/26 ,  G02B21/365 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30024

Abstract: A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.

公开(公告)号：US11821826B2

公开(公告)日：2023-11-21

申请号：US17853251

申请日：2022-06-29

Applicant: Clarapath, Inc.

Inventor： Partha P. Mitra ,  Charles Cantor ,  Baris Yagci ,  David Kleinfeld ,  Cong Zhang ,  Steven Smith

IPC: G01N1/36 ,  G06T7/521 ,  G01B11/22 ,  G01N1/06 ,  G01N1/28 ,  G06T7/00 ,  G01N1/31 ,  G01N35/00 ,  G01N21/64

CPC classification number: G01N1/36 ,  G01B11/22 ,  G01N1/06 ,  G01N1/286 ,  G01N1/312 ,  G01N21/6456 ,  G01N21/6486 ,  G01N35/00603 ,  G01N35/00613 ,  G01N35/00732 ,  G06T7/0014 ,  G06T7/521 ,  G01N2001/2873 ,  G01N2035/00039 ,  G01N2035/00861 ,  G01N2035/00881 ,  G06T2207/30024

Abstract: The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.

公开(公告)号：US20230341298A1

公开(公告)日：2023-10-26

申请号：US18299759

申请日：2023-04-13

Applicant: LEICA MIKROSYSTEME GMBH

Inventor： Matthias Katzengruber ,  Robert Ranner ,  Paul Wurzinger

IPC: G01N1/06 ,  G01N1/28

CPC classification number: G01N1/06 ,  G01N1/286 ,  G01N2001/061 ,  G01N2001/065 ,  G01N2001/068 ,  G01N2001/2873

Abstract: A microtome system for cutting sections from a specimen includes a knife including a knife edge configured to cut a section from the specimen, a knife holder, a specimen holder, an illumination, a first actor, a detector, and a controller. The knife holder and specimen holder are configured to be relatively moveable in a cutting direction. The first actor is configured to cause a rotation of the knife holder or specimen holder about an axis. The illumination is configured to illuminate a gap between a front face of the specimen and the knife edge to generate a light gap. The detector is configured to detect a geometric feature of the light gap. The controller is configured to automatically align, or provide indications to manually align, the knife edge with the front face, by controlling the first actor depending on the detected geometric feature.

公开(公告)号：US11796429B2

公开(公告)日：2023-10-24

申请号：US17015813

申请日：2020-09-09

Applicant: BioPath Automation, L.L.C. ,  Sakura Finetek U.S.A., Inc.

Inventor： Warren P. Williamson, IV ,  Richard W. Dapson ,  Amit D. Shah

IPC: G01N1/31 ,  G01N1/36 ,  G01N1/06

CPC classification number: G01N1/31 ,  G01N1/36 ,  G01N1/06 ,  G01N2001/368

Abstract: A sectionable tissue sample support structure including a gel compound formed into a self supporting geometric shape for retention and orientation of at least one tissue sample during a histopathology process including processing, embedding and microtome slicing of the tissue sample. A method of orienting, processing, embedding and microtome slicing a tissue sample using a gel compound preformed into a self supporting geometric shape. A combination including the sectionable tissue sample support structure and a package containing the sectionable tissue sample support structure.

公开(公告)号：US11796427B2

公开(公告)日：2023-10-24

申请号：US16650880

申请日：2017-09-29

Applicant: Leica Microsystems Ltd., Shanghai

Inventor： Gang Zhou

IPC: F16H3/40 ,  G01N1/06 ,  F16H3/34

CPC classification number: G01N1/06 ,  F16H3/34 ,  F16H3/40 ,  G01N2001/065

Abstract: A rotating direction change device for a microtome includes: a first shaft arranged in a first fixed position; a first gear wheel non-rotatably mounted to the first shaft; a second shaft movable in a first direction; a second gear wheel non-rotatably mounted to the second shaft; a third shaft movable in a second direction; a third gear wheel non-rotatably mounted to the third shaft; and a first connection part connecting the second shaft and the third shaft such that the second gear wheel is constantly meshed with the third gear wheel, in which the second gear wheel can be driven by the first gear wheel directly or indirectly. Hence, the rotating direction change device has advantages of simple structure and low friction.

公开(公告)号：US20230314284A1

公开(公告)日：2023-10-05

申请号：US18127516

申请日：2023-03-28

Applicant: Clarapath, Inc.

Inventor： Partha P. Mitra ,  Alexander S. Tolpygo ,  Robert L. Kleinberg

IPC: G01N1/06

CPC classification number: G01N1/06 ,  G01N33/48764

Abstract: A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.

公开(公告)号：US20230314283A1

公开(公告)日：2023-10-05

申请号：US18126272

申请日：2023-03-24

Applicant: Clarapath, Inc.

Inventor： Jerry R. Pinto ,  Robert Shusko ,  Janak Sewkarran ,  Partha P. Mitra ,  Charles R. Cantor

IPC: G01N1/06 ,  G01N1/36 ,  B01L3/00

CPC classification number: G01N1/06 ,  B01L3/508 ,  G01N1/36 ,  B01L2300/043 ,  B01L2300/046 ,  B01L2300/069 ,  B01L2300/0809 ,  G01N2001/065 ,  G01N2001/315

Abstract: There is provided a histology system that comprises a microtome configured to expose a face of a tissue block comprising a tissue sample embedded in an embedding material and remove one or more tissue sections from the sample, a hydration system configured to hydrate the tissue block by depositing a hydrating liquid on the face of the tissue block, and a transfer system configured to transfer the one or more tissue sections from the microtome to one or more slides. In some embodiments, the hydration system is configured to produce droplet condensation of the hydrating liquid and deposit the condensation on the face of the tissue block.

公开(公告)号：US20230204465A1

公开(公告)日：2023-06-29

申请号：US18111195

申请日：2023-02-17

Applicant: DEEP BRAIN INNOVATIONS LLC

Inventor： Robert Strother ,  Stuart Rubin ,  Jonathan Sakai

IPC: G01N1/06 ,  B26D7/18 ,  G01N1/28

CPC classification number: G01N1/06 ,  B26D7/1845 ,  G01N1/286 ,  Y10T83/0448 ,  Y10T83/0453 ,  Y10T83/2066 ,  Y10T83/2096 ,  G01N2001/063 ,  G01N2001/066 ,  G01N2001/2873 ,  G01N2001/061

Abstract: A neurostimulation system is shown and described. The neurostimulation system may include a stimulation device implantable into a patient, a lead operatively coupled with the stimulation device, a first power cell providing power to the stimulation device where the first power cell is charged by an externally applied AC (High HF) magnetic field.