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公开(公告)号：US09636361B2
公开(公告)日：2017-05-02
申请号：US14221500
申请日：2014-03-21
申请人： LiveLeaf, Inc.
发明人： Alexander L Huang , Gin Wu
CPC分类号： A61K33/40 , A01N59/00 , A01N2300/00 , A61K31/05 , A61K36/00 , A61K36/185 , A61K36/82 , A61K2300/00 , A01N25/08 , A01N25/22 , A01N65/08 , A01N65/20 , A01N65/40 , A01N65/42 , A01N65/44
摘要： The present invention is directed to a method and a composition for producing and using a plant-based biocidal solution. The plant-based biocidal solution contains a bioactive material and a plant-based substance formed from the cellular material of a plant. The plant-based substance is capable of binding to the bioactive material. In some embodiments, the bioactive material is hydrogen peroxide. The hydrogen peroxide can be added exogenously or generated endogenously. In accordance with further embodiments, the plant-based biocidal solution can be applied to a target, thereby impairing the target. In some embodiments, the target can be a pathogen. In accordance with another embodiment, the plant-based substance of the plant-based biocidal solution can form a microscopic cluster, a complex, or an aggregate for providing sufficient bioactive material to overcome the defense mechanism of the target.
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2.发明授权Tannin formulation for treating gastrointestinal spasms in a subject having diverticulitis 有权用于治疗患有憩室炎的受试者的胃肠道痉挛的单宁制剂公开(公告)号：US08772351B1
公开(公告)日：2014-07-08
申请号：US14173357
申请日：2014-02-05
申请人： LiveLeaf, Inc.
发明人： Alexander L Huang , Gin Wu
CPC分类号： A61K33/40 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/7028 , A61K31/7034 , A61K31/7048 , A61K36/185 , A61K36/22 , A61K36/82 , A61K45/06 , A61K2300/00
摘要： Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
摘要翻译： 提供了治疗胃肠道痉挛的方法。 例如，提供了治疗胃肠道痉挛的方法，不需要使用已显示出（i）提供缓解的全身药物的方法，（ii）引起不良副作用，（iii）限制活动，（iv）恶化现有的 胃肠道疾病，（v）在包括胃肠道痉挛的几种胃肠病症中是不推荐的，或（vi）在没有腹泻的情况下不推荐。
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3.发明授权Therapeutic composition produced using Camellia sinensis leaves and hydrogen peroxide 有权使用山茶叶和过氧化氢生产的治疗组合物公开(公告)号：US08586110B2
公开(公告)日：2013-11-19
申请号：US13680007
申请日：2012-11-16
申请人： LiveLeaf, Inc.
发明人： Alexander L Huang , Gin Wu
CPC分类号： A61K36/82 , A01N59/00 , A01N65/08 , A23K20/111 , A23L33/105 , A61K31/05 , A61K31/122 , A61K33/40 , A61K36/185 , A61K36/22 , A61K38/44 , C07G1/00 , C07K1/1072 , A61K2300/00
摘要： Methods of and compositions for producing and using plant-based materials are provided. The methods include using biopolymers or their synthetic equivalents combined with a stable source of reactive oxygen species that when applied to or combined with a separate source of oxido-reducing enzyme or catalyst will cause the formation of an activated biopolymer with increased protein binding affinity and microbial control activities.
摘要翻译： 提供了生产和使用植物材料的方法和组合物。 这些方法包括使用生物聚合物或其合成当量与稳定的活性氧源组合，当应用于或与单独的氧化还原酶或催化剂的来源组合时，将引起具有增加的蛋白质结合亲和力和微生物的活化生物聚合物的形成 控制活动。
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4.发明申请THERAPEUTIC COMPOSITION PRODUCED USING CAMELLIA SINENSIS LEAVES AND HYDROGEN PEROXIDE 有权使用青蒿素和过氧化氢生产的治疗组合物公开(公告)号：US20130078322A1
公开(公告)日：2013-03-28
申请号：US13680007
申请日：2012-11-16
申请人： Liveleaf, Inc.
发明人： Alexander L. Huang , Gin Wu
CPC分类号： A61K36/82 , A01N59/00 , A01N65/08 , A23K20/111 , A23L33/105 , A61K31/05 , A61K31/122 , A61K33/40 , A61K36/185 , A61K36/22 , A61K38/44 , C07G1/00 , C07K1/1072 , A61K2300/00
摘要： Methods of and compositions for producing and using plant-based materials are provided. The methods include using biopolymers or their synthetic equivalents combined with a stable source of reactive oxygen species that when applied to or combined with a separate source of oxido-reducing enzyme or catalyst will cause the formation of an activated biopolymer with increased protein binding affinity and microbial control activities.
摘要翻译： 提供了生产和使用植物材料的方法和组合物。 这些方法包括使用生物聚合物或其合成当量与稳定的活性氧源组合，当应用于或与单独的氧化还原酶或催化剂的来源组合时，将引起具有增加的蛋白质结合亲和力和微生物的活化生物聚合物的形成 控制活动。
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5.发明授权公开(公告)号：US08343552B2
公开(公告)日：2013-01-01
申请号：US12715270
申请日：2010-03-01
申请人： Alexander L. Huang , Gin Wu
发明人： Alexander L. Huang , Gin Wu
CPC分类号： A61K36/82 , A01N59/00 , A01N65/08 , A23K20/111 , A23L33/105 , A61K31/05 , A61K31/122 , A61K33/40 , A61K36/185 , A61K36/22 , A61K38/44 , C07G1/00 , C07K1/1072 , A61K2300/00
摘要： Methods of and compositions for producing and using plant-based materials are provided. The methods include using biopolymers or their synthetic equivalents combined with a stable source of reactive oxygen species that when applied to or combined with a separate source of oxido-reducing enzyme or catalyst will cause the formation of an activated biopolymer with increased protein binding affinity and microbial control activities.
摘要翻译： 提供了生产和使用植物材料的方法和组合物。 这些方法包括使用生物聚合物或其合成当量与稳定的活性氧源组合，当应用于或与单独的氧化还原酶或催化剂的来源组合时，将引起具有增加的蛋白质结合亲和力和微生物的活化生物聚合物的形成 控制活动。
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公开(公告)号：US09603871B2
公开(公告)日：2017-03-28
申请号：US15270491
申请日：2016-09-20
申请人： LiveLeaf, Inc.
发明人： Alexander L Huang , Gin Wu
IPC分类号： A61K33/40 , A61K31/353 , A61K31/7034 , A61K31/192 , A61K35/22 , A61K36/82 , A61K36/185 , A61K31/7048 , A61K36/22
CPC分类号： A61K33/40 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/7028 , A61K31/7034 , A61K31/7048 , A61K36/185 , A61K36/22 , A61K36/82 , A61K45/06 , A61K2300/00
摘要： Methods of treating gastro-esophageal reflux disease in a subject are provided. The methods can include administering an effective amount of a formulation to treat the gastroesophageal reflux disease, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient; wherein, the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and, the composition at least inhibits a gastrointestinal spasm associated with gastroesophageal reflux disease in the subject when compared to a second subject in a control group in which the composition was not administered.
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7.发明授权公开(公告)号：US09089596B1
公开(公告)日：2015-07-28
申请号：US14662725
申请日：2015-03-19
申请人： LiveLeaf, Inc.
发明人： Alexander L Huang , Gin Wu
IPC分类号： A61K36/82 , A61K36/22 , A61K36/185
CPC分类号： A61K33/40 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/7028 , A61K31/7034 , A61K31/7048 , A61K36/185 , A61K36/22 , A61K36/82 , A61K45/06 , A61K2300/00
摘要： Methods of treating drug side-effects including gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
摘要翻译： 提供了治疗包括胃肠道痉挛在内的药物副作用的方法，不需要使用已显示出（i）提供缓解的全身药物的方法，（ii）引起不良副作用，（iii）限制活性，（iv） 恶化现有的胃肠道疾病，（v）在包括胃肠道痉挛的几种胃肠病症中不推荐，或（vi）在没有腹泻的情况下不推荐。
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公开(公告)号：US09023895B1
公开(公告)日：2015-05-05
申请号：US14584419
申请日：2014-12-29
申请人： LiveLeaf, Inc.
发明人： Alexander L Huang , Gin Wu
IPC分类号： A61K36/82 , A61K33/40 , A61K31/353 , A61K31/192 , A61K31/7034 , A61K36/22 , A61K36/185
CPC分类号： A61K33/40 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/7028 , A61K31/7034 , A61K31/7048 , A61K36/185 , A61K36/22 , A61K36/82 , A61K45/06 , A61K2300/00
摘要： Methods of treating necrotic enteritis are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
摘要翻译： 提供了治疗坏死性肠炎的方法，这种不需要使用全身药物的方法，显示：（i）缓解缓解，（ii）引起不良副作用，（iii）限制活动，（iv）恶化现有胃肠道病症， （v）在包括胃肠道痉挛的几种胃肠病症中是不推荐的，或（vi）在没有腹泻的情况下不推荐。
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公开(公告)号：US08809399B1
公开(公告)日：2014-08-19
申请号：US14272047
申请日：2014-05-07
申请人： LiveLeaf, Inc.
发明人： Alexander L Huang , Gin Wu
IPC分类号： A01N31/00 , A61K31/075 , A61K51/00 , A61M36/14 , A01N39/00 , A61K33/40 , A61K31/7028 , A61K36/82 , A61K31/192 , A61K36/185
CPC分类号： A61K33/40 , A61K31/192 , A61K31/352 , A61K31/353 , A61K31/7028 , A61K31/7034 , A61K31/7048 , A61K36/185 , A61K36/22 , A61K36/82 , A61K45/06 , A61K2300/00
摘要： Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
摘要翻译： 提供了治疗胃肠道痉挛的方法。 例如，提供了治疗胃肠道痉挛的方法，不需要使用已显示出（i）提供缓解的全身药物的方法，（ii）引起不良副作用，（iii）限制活动，（iv）恶化现有的 胃肠道疾病，（v）在包括胃肠道痉挛的几种胃肠病症中是不推荐的，或（vi）在没有腹泻的情况下不推荐。
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公开(公告)号：US20140199412A1
公开(公告)日：2014-07-17
申请号：US14203517
申请日：2014-03-10
申请人： LiveLeaf, Inc.
发明人： ALEXANDER L. HUANG , Gin Wu
IPC分类号： A61K33/40 , A61K36/185 , A61K31/192 , A61K31/05 , A61K31/353 , A61K36/22 , A61K36/82
CPC分类号： A61K33/40 , A61K31/05 , A61K31/192 , A61K31/35 , A61K31/353 , A61K31/365 , A61K31/366 , A61K31/7032 , A61K36/185 , A61K36/22 , A61K36/82 , Y02A50/473 , Y02A50/481
摘要： The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.
摘要翻译： 本文提供的教导通常涉及选择性地增加酚化合物在靶位点的生物活性的位点活化结合系统。 更具体地说，这里教导的系统包括与活性氧物质结合的酚类化合物，其中酚类化合物和活性氧在氧化还原酶存在下在目标区域反应。
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