公开(公告)号：US09186237B2

公开(公告)日：2015-11-17

申请号：US13398577

申请日：2012-02-16

申请人： Jason A. Galdonik ,  Matthew F. Ogle ,  Edward Anderson ,  Mark W. I. Webster

发明人： Jason A. Galdonik ,  Matthew F. Ogle ,  Edward Anderson ,  Mark W. I. Webster

IPC分类号： A61F2/01

CPC分类号： A61F2/013 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61F2/01 ,  A61F2/24 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/008 ,  A61F2230/0093

摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.

公开(公告)号：US20110230859A1

公开(公告)日：2011-09-22

申请号：US13117452

申请日：2011-05-27

申请人： Jason A. Galdonik ,  Edward Anderson ,  Kavitha Ganesan ,  Greg Boldenow ,  John Kirchgessner ,  Grazyna Wlodarski

发明人： Jason A. Galdonik ,  Edward Anderson ,  Kavitha Ganesan ,  Greg Boldenow ,  John Kirchgessner ,  Grazyna Wlodarski

IPC分类号： A61M25/00

CPC分类号： A61B17/22 ,  A61B17/221 ,  A61B17/2833 ,  A61B17/2909 ,  A61B2017/0046 ,  A61B2017/22079 ,  A61B2017/292 ,  A61B2017/2923 ,  A61F2/013 ,  A61M25/0108 ,  A61M2025/0008

摘要： Systems for less invasive medical procedures comprise a filter device mounted on an integrated guiding structure and an aspiration catheter. These components can be used together or separately, and the system can be used with other medical devices that are designed for less invasive procedures, such as procedures in a patient's vasculature. The filter device can involve improved torque coupling with a torque coupler associated with a resilient member that correspondingly also provides increased flexibility relative to an overtube that forms a tube for the remaining portions of the device. An actuation tool for the filter device used a systematic loading procedure for proper loading of the corewire and overtube into the actuation tool. A fiber cartridge comprises fibers loaded as a bundle into the cartridge for delivery with the ends of the fibers respectively bonded to radiopaque markers that can be visualized to come together when the filter is properly deployed. The aspiration catheter generally has a rapid exchange format. The catheter can have a radiopaque band that is held in place under metal wire embedded within the polymer forming the tube of the catheter. In some embodiments, the aspiration catheter has a small diameter distal portion that can access into small diameter vessels in which the distal portion has a smaller average diameter than the remaining tube of the catheter.

摘要翻译： 用于较少侵入性医疗程序的系统包括安装在集成引导结构和抽吸导管上的过滤装置。 这些组件可以一起使用或分开使用，并且该系统可以与其他设计用于较小侵入性程序的医疗设备一起使用，例如患者脉管系统中的程序。 过滤装置可以涉及与与弹性构件相关联的扭矩联接器的改进的扭矩耦合，其相应地还相对于形成用于装置的其余部分的管的外套管提供增加的灵活性。 用于过滤装置的致动工具使用系统加载程序来将芯线和外套管正确地装载到致动工具中。 纤维筒包括作为束装入筒中的纤维，用于输送，纤维的端部分别结合到不透射线的标记上，当过滤器被适当地展开时可以将其可视化到一起。 抽吸导管通常具有快速的交换格式。 导管可以具有不透射线的带，其被保持在嵌入在形成导管的管的聚合物内的金属线下的适当位置。 在一些实施例中，抽吸导管具有小直径远端部分，其可以进入小直径血管，其中远侧部分具有比导管的剩余管更小的平均直径。

公开(公告)号：US07988705B2

公开(公告)日：2011-08-02

申请号：US10979439

申请日：2004-11-02

申请人： Jason A. Galdonik ,  James Pokorney ,  Matthew F. Ogle

发明人： Jason A. Galdonik ,  James Pokorney ,  Matthew F. Ogle

IPC分类号： A61M29/00

CPC分类号： A61M25/09016 ,  A61M25/0023 ,  A61M25/09025

摘要： An integrated guiding device has a tube and a corewire within the tube and a torque coupler. The torque coupler can couple the rotational motion of the tube with the rotational motion of the corewire. The wire can be moved longitudinally at least some amount relative to the tube. The device can further comprise a functional medical structure, such as an embolism protection structure. The device can be used in medical procedures, such as less invasive procedures within the cardiovascular system. Improved fiber based embolism protection devices comprise fiber bundles that are twisted prior to delivery.

摘要翻译： 集成引导装置在管内具有管和芯线，以及扭矩耦合器。 扭矩耦合器可将管的旋转运动与芯线的旋转运动耦合。 电线可以相对于管子至少一定数量的纵向移动。 该装置还可以包括诸如栓塞保护结构的功能医疗结构。 该装置可用于医疗程序，例如心血管系统内的侵入性较小的程序。 改进的基于纤维的栓塞保护装置包括在输送之前被扭曲的纤维束。

公开(公告)号：US07303575B2

公开(公告)日：2007-12-04

申请号：US10414909

申请日：2003-04-16

申请人： Matthew F. Ogle

发明人： Matthew F. Ogle

IPC分类号： A61M29/00

CPC分类号： A61B17/12022 ,  A61B17/12027 ,  A61B17/12036 ,  A61B17/12109 ,  A61B17/12168 ,  A61B17/12172 ,  A61B17/1219 ,  A61F2/01 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/008 ,  A61F2230/0091 ,  A61F2250/0067 ,  A61L31/04 ,  A61L31/14 ,  A61L2430/36

摘要： Embolism protection devices can be formed with a biocompatible expandable polymer that can expand upon release within a patient's vessel. Upon release, the structure can be configured to filter flow through the vessel. The material of the embolism protection devices can release one or more biologically active agents, such as a thrombolitic agent, including, for example, tPA. Alternatively or additionally, the embolism protection device can be connected to a tether that elutes one or more biologically active agents.

摘要翻译： 栓塞保护装置可以用生物相容性可膨胀聚合物形成，其可以在患者血管内释放时膨胀。 释放后，该结构可被配置成过滤通过容器的流动。 栓塞保护装置的材料可以释放一种或多种生物活性剂，例如血栓栓塞剂，包括例如tPA。 或者或另外，栓塞保护装置可以连接到洗脱一种或多种生物活性剂的系链。

公开(公告)号：US20210267744A1

公开(公告)日：2021-09-02

申请号：US17104476

申请日：2020-11-25

申请人： Lumen Biomedical, Inc.

发明人： Jason A. Galdonik ,  Matthew F. Ogle ,  Edward J. Anderson ,  Mark W.I. Webster

IPC分类号： A61F2/01 ,  A61B17/12

摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.

公开(公告)号：US10682217B2

公开(公告)日：2020-06-16

申请号：US15704196

申请日：2017-09-14

申请人： Lumen Biomedical, Inc.

发明人： Kavitha Ganesan ,  Matthew F. Ogle

IPC分类号： A61F2/01 ,  A61B17/12 ,  A61M25/00 ,  A61M25/10 ,  A61B17/22

摘要： Filtration systems with integrated filter element(s) forming portions of the wall of the filtration catheter are disclosed. The filtration catheters disclosed herein are designed to be used alone or in conjunction with another filter device to provide embolic protection of both carotid arteries. Occlusive element such as balloon is placed on the exterior of the filtration catheter to redirect blood flow in the vessels during the filtration process as well as to help anchor the filtration catheter inside the vessel. The integrated filter element(s) does not require collapsing thus significantly reduces the complexity of the filtration system retrieval process and the chances of releasing emboli back into the blood stream. The compact design of the filtration systems makes them particularly suitable for embolic protection during endovascular procedures on or close to the heart.

公开(公告)号：US09943396B2

公开(公告)日：2018-04-17

申请号：US14881711

申请日：2015-10-13

申请人： Lumen Biomedical, Inc.

发明人： Jason A. Galdonik ,  Matthew F. Ogle ,  Edward Anderson ,  Mark W. I. Webster

IPC分类号： A61M29/00 ,  A61F2/01 ,  A61B17/12 ,  A61F2/24

CPC分类号： A61F2/013 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61F2/01 ,  A61F2/24 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/008 ,  A61F2230/0093

摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.

公开(公告)号：US09795470B2

公开(公告)日：2017-10-24

申请号：US13742760

申请日：2013-01-16

申请人： Lumen Biomedical, Inc.

发明人： Kavitha Ganesan ,  Matthew F. Ogle

IPC分类号： A61F2/01 ,  A61B17/12 ,  A61M25/10 ,  A61B17/22

CPC分类号： A61F2/01 ,  A61B17/12031 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/22067 ,  A61B2017/22079 ,  A61F2/013 ,  A61M25/0029 ,  A61M25/10 ,  A61M25/1011 ,  A61M25/104 ,  A61M2025/1052 ,  A61M2025/1095

摘要： Filtration systems with integrated filter element(s) forming portions of the wall of the filtration catheter are disclosed. The filtration catheters disclosed herein are designed to be used alone or in conjunction with another filter device to provide embolic protection of both carotid arteries. Occlusive element such as balloon is placed on the exterior of the filtration catheter to redirect blood flow in the vessels during the filtration process as well as to help anchor the filtration catheter inside the vessel. The integrated filter element(s) does not require collapsing thus significantly reduces the complexity of the filtration system retrieval process and the chances of releasing emboli back into the blood stream. The compact design of the filtration systems makes them particularly suitable for embolic protection during endovascular procedures on or close to the heart.

公开(公告)号：US08206412B2

公开(公告)日：2012-06-26

申请号：US12489108

申请日：2009-06-22

申请人： Jason A. Galdonik ,  Matthew F. Ogle ,  Edward Anderson ,  Mark W. I. Webster

发明人： Jason A. Galdonik ,  Matthew F. Ogle ,  Edward Anderson ,  Mark W. I. Webster

IPC分类号： A61F2/01

CPC分类号： A61F2/013 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61F2/01 ,  A61F2/24 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/008 ,  A61F2230/0093

摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.

摘要翻译： 描述了各种装置以提供从主动脉到左颈动脉和右颈动脉的流动的过滤。 过滤器可以通过一个或多个外周动脉进入期望的位置。 单个过滤器装置可以提供期望的过滤，或者可以使用多个装置。 特别地，单个过滤器装置可以跨越头臂动脉和左颈动脉之间。 这些过滤装置可以有效地用于捕获在心脏手术过程中产生的栓子，以便栓塞不会到达患者的脑部，导致栓塞引起中风或其他不良事件。 特别地，这些过滤器可以在心脏经皮手术期间使用，例如血管内心脏瓣膜置换。

公开(公告)号：US20110313445A1

公开(公告)日：2011-12-22

申请号：US13218183

申请日：2011-08-25

申请人： Jason A. Galdonik ,  Matthew F. Ogle ,  Edward Anderson ,  Mark W. I. Webster

发明人： Jason A. Galdonik ,  Matthew F. Ogle ,  Edward Anderson ,  Mark W. I. Webster

IPC分类号： A61F2/01

CPC分类号： A61F2/013 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61F2/01 ,  A61F2/24 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/008 ,  A61F2230/0093

摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.

摘要翻译： 描述了各种装置以提供从主动脉到左颈动脉和右颈动脉的流动的过滤。 过滤器可以通过一个或多个外周动脉进入期望的位置。 单个过滤器装置可以提供期望的过滤，或者可以使用多个装置。 特别地，单个过滤器装置可以跨越头臂动脉和左颈动脉之间。 这些过滤装置可以有效地用于捕获在心脏手术过程中产生的栓子，以便栓塞不会到达患者的脑部，导致栓塞引起中风或其他不良事件。 特别地，这些过滤器可以在心脏经皮手术期间使用，例如血管内心脏瓣膜置换。