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公开(公告)号：US08409237B2
公开(公告)日：2013-04-02
申请号：US10854920
申请日：2004-05-27
IPC分类号： A61M29/00
CPC分类号： A61B17/22 , A61B2017/22034 , A61B2017/22035 , A61B2017/22079 , A61B2217/005 , A61F2/01
摘要： Methods for the removal of an embolism protection device use aspiration during the drawing of the embolism protection device into the catheter. Generally, the embolism protection device comprises a three dimensional filtering matrix that provides improved filtering without blocking the flow through the patient's vessel. In some embodiments, the embolism protection device can be actuated between a deployed configuration and a removal configuration with a reduced area across the cross section of the vessel lumen. The embolism protection device in the removal configuration can be drawn within the aspiration catheter. The aspiration catheter can have a distal portion with an expanded compartment with an average diameter at least about 20 percent larger than the average diameter of the shaft of the catheter within about 10 centimeters of the expanded compartment. In a rapid exchange version, the rapid exchange segment can have a length of at least about 10 centimeters.
摘要翻译： 在将栓塞保护装置拉入导管期间，用于去除栓塞保护装置的方法使用抽吸。 通常，栓塞保护装置包括三维过滤矩阵，其提供改进的过滤而不阻塞通过患者血管的流动。 在一些实施例中，栓塞保护装置可以在展开构造和移除构造之间被致动，并且在血管内腔的横截面上具有减小的面积。 拔除结构中的栓塞保护装置可以在抽吸导管内拉出。 抽吸导管可以具有远端部分，其具有扩张隔室，平均直径比扩张隔室的约10厘米内的导管轴的平均直径至少大约20％。 在快速交换版本中，快速交换段可以具有至少约10厘米的长度。
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2.发明授权Steerable device having a corewire within a tube and combination with a functional medical component 有权具有在管内的芯线并与功能医疗部件组合的可转向装置公开(公告)号：US08092483B2
公开(公告)日：2012-01-10
申请号：US11072001
申请日：2005-03-04
IPC分类号： A61M29/00
CPC分类号： A61M25/0138 , A61M25/0054 , A61M25/0133
摘要： An integrated guiding device has a tube and a corewire within the tube and a torque coupler. The torque coupler can couple the rotational motion of the tube with the rotational motion of the corewire. The wire can be moved longitudinally at least some amount relative to the tube. The device can further comprise a functional medical structure, such as an embolism protection structure. The device can be used in medical procedures, such as less invasive procedures within the cardiovascular system. Improved fiber based embolism protection devices comprise fiber bundles that are twisted prior to delivery.
摘要翻译： 集成引导装置在管内具有管和芯线，以及扭矩耦合器。 扭矩耦合器可将管的旋转运动与芯线的旋转运动耦合。 电线可以相对于管子至少一定数量的纵向移动。 该装置还可以包括诸如栓塞保护结构的功能医疗结构。 该装置可用于医疗程序，例如心血管系统内的侵入性较小的程序。 改进的基于纤维的栓塞保护装置包括在输送之前被扭曲的纤维束。
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3.发明授权Steerable device having a corewire within a tube and combination with a functional medical component 有权具有在管内的芯线并与功能医疗部件组合的可转向装置公开(公告)号：US07988705B2
公开(公告)日：2011-08-02
申请号：US10979439
申请日：2004-11-02
IPC分类号： A61M29/00
CPC分类号： A61M25/09016 , A61M25/0023 , A61M25/09025
摘要： An integrated guiding device has a tube and a corewire within the tube and a torque coupler. The torque coupler can couple the rotational motion of the tube with the rotational motion of the corewire. The wire can be moved longitudinally at least some amount relative to the tube. The device can further comprise a functional medical structure, such as an embolism protection structure. The device can be used in medical procedures, such as less invasive procedures within the cardiovascular system. Improved fiber based embolism protection devices comprise fiber bundles that are twisted prior to delivery.
摘要翻译： 集成引导装置在管内具有管和芯线，以及扭矩耦合器。 扭矩耦合器可将管的旋转运动与芯线的旋转运动耦合。 电线可以相对于管子至少一定数量的纵向移动。 该装置还可以包括诸如栓塞保护结构的功能医疗结构。 该装置可用于医疗程序，例如心血管系统内的侵入性较小的程序。 改进的基于纤维的栓塞保护装置包括在输送之前被扭曲的纤维束。
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公开(公告)号：US07976516B2
公开(公告)日：2011-07-12
申请号：US11157476
申请日：2005-06-21
IPC分类号： A61M5/00
CPC分类号： A61M25/0905 , A61B2017/00477
摘要： A biocompatible medical device having a segmented element including a first segment having a first shaped interface and a second segment having a second shaped interface configured to operably couple the first shaped interface. When the first shaped interface is engaging the second shaped interface to form a joined segmented element, the first segment and the second segment cannot be decoupled by movement along an axis through the element. The medical device further includes a locking element configured to engage the joined segmented element with a sliding motion to prevent decoupling of the first segment with respect to the second segment by preventing significant relative movement of the segments with a component of the movement perpendicular to the axis.
摘要翻译： 一种具有分段元件的生物相容性医疗装置，其包括具有第一形状界面的第一区段和具有构造成可操作地连接第一成形界面的第二形状界面的第二区段。 当第一形状界面接合第二形状界面以形成连接的分段元件时，第一段和第二段不能通过沿着穿过该元件的轴的移动来解耦。 该医疗装置还包括锁定元件，该锁定元件构造成以滑动运动与接合的分段元件接合，以防止第一段相对于第二段解耦，这是通过阻止具有垂直于该轴线的运动分量的段的显着相对运动 。
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公开(公告)号：US07879062B2
公开(公告)日：2011-02-01
申请号：US10795131
申请日：2004-03-06
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/09 , A61M2025/09175 , B33Y80/00
摘要： Improved embolism protection devices comprises fibers that can have one configuration for delivery of the device and a second configuration in which the device is deployed for filtering of flow within a vessel. In some embodiments, the fibers can be connected to a fiber support, which is connected to an actuating element. The actuating element controls the transition from the delivery configuration to the deployed configuration. The embolism protection device can comprise a guidewire. The fibers can be attached at one end to a fiber support structure and at another end to the guidewire. A hypotube can be attached to the proximal end of the fibers while the guidewire is attached at the distal end of the fibers with the guidewire extending within a central channel of the hypotube. The hypotube can be used to guide the delivery of treatment structures, such as a balloon and/or a stent.
摘要翻译： 改进的栓塞保护装置包括可以具有用于装置的输送的一种配置的纤维和其中部署用于过滤容器内的流动的装置的第二配置。 在一些实施例中，纤维可以连接到连接到致动元件的纤维支撑件。 致动元件控制从传送配置到部署配置的过渡。 栓塞保护装置可以包括导丝。 纤维的一端可以连接到纤维支撑结构，另一端可以连接到导丝。 海波管可以附着在纤维的近端，而导丝被连接在纤维的远端，导丝延伸在海波管的中心通道内。 海波管可用于引导治疗结构的传送，例如气囊和/或支架。
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6.发明授权Embolectomy devices and methods for treatment of acute ischemic stroke condition 有权用于治疗急性缺血性卒中病症的手术切除装置和方法公开(公告)号：US08814892B2
公开(公告)日：2014-08-26
申请号：US13085109
申请日：2011-04-12
IPC分类号： A61B17/22 , A61B17/221
CPC分类号： A61B17/221 , A61B2017/22044 , A61B2017/22067 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/320716 , A61F2/013 , A61F2002/016 , A61F2230/0065 , A61F2230/0076 , A61F2230/0097
摘要： Clot engagement element comprising bundle of unwoven fibers can be assembled to form an acute stroke treatment device. The device has the capability of forming a three dimensional filtration matrix comprising effective pores with a distribution of sizes. The bundle of fiber design allows the device to be effectively delivered into circuitous cerebral arteries to remove clot that causes stroke. The fiber bundle based filtration matrix offers the advantages of conforming to the changing inner perimeter of a blood vessel during a clot removal process and thus the capability to effectively retain and remove a clot in the vessel. The filtration matrix offers the additional advantage to trap any break-off of the clot during the removal process. A plurality of fiber bundles can be combined to form an effective clot engagement element. Supplemental engagement structure as well as mechanical treatment structure can be integrated into the stroke treatment device. The deployment of the fiber based elements can be facilitated by actuation tool. Aspiration can be employed during the clot removal process.
摘要翻译： 可以组装包括无纺纤维束的凝块接合元件以形成急性中风治疗装置。 该装置具有形成具有分布尺寸的有效孔的三维过滤基质的能力。 纤维束设计允许将装置有效地输送到迂回的脑动脉中以去除导致中风的凝块。 基于纤维束的过滤基质提供了在凝块移除过程期间符合血管内周的不断变化的优点，并因此具有有效地保持和去除血管中凝块的能力。 过滤基质提供额外的优点，以在去除过程中捕获凝块的任何断裂。 多个纤维束可以组合以形成有效的凝块接合元件。 补充接合结构以及机械治疗结构可以集成到中风治疗装置中。 可以通过致动工具来促进基于纤维的元件的部署。 凝血清除过程中可以使用吸入。
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7.发明申请EMBOLIC PROTECTION DURING PERCUTANEOUS HEART VALVE REPLACEMENT AND SIMILAR PROCEDURES 审中-公开超声心动图更换和类似程序期间的手术保护公开(公告)号：US20120150211A1
公开(公告)日：2012-06-14
申请号：US13398577
申请日：2012-02-16
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61F2/01 , A61F2/24 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0093
摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.
摘要翻译： 描述了各种装置以提供从主动脉到左颈动脉和右颈动脉的流动的过滤。 过滤器可以通过一个或多个外周动脉进入期望的位置。 单个过滤器装置可以提供期望的过滤，或者可以使用多个装置。 特别地，单个过滤器装置可以跨越头臂动脉和左颈动脉之间。 这些过滤装置可以有效地用于捕获在心脏手术过程中产生的栓子，以便栓塞不会到达患者的脑部，导致栓塞引起中风或其他不良事件。 特别地，这些过滤器可以在心脏经皮手术期间使用，例如血管内心脏瓣膜置换。
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公开(公告)号：US08052714B2
公开(公告)日：2011-11-08
申请号：US11603315
申请日：2006-11-21
IPC分类号： A61M29/00
CPC分类号： A61K49/0409
摘要： Medical devices with radiopaque three dimensional filtration matrices provide for improved visualization of the device within a vessel. In some embodiments, the three dimensional filtration matrix comprises fibers, such as surface capillary fibers. Visualization of the three dimensional filtration matrix provides for an evaluation of the proper deployment of the three dimensional filtration matrix. Radiopaque surface capillary fibers can be advantageously incorporated into other medical devices. Radiopaque surface capillary fibers can be formed by extrusion of a radiopaque polymer or polymer composite.
摘要翻译： 具有不透射线的三维过滤基质的医疗装置提供容器内装置的改进的可视化。 在一些实施例中，三维过滤基质包括纤维，例如表面毛细纤维。 三维过滤矩阵的可视化提供了三维过滤矩阵的适当部署的评估。 不透射线的表面毛细纤维可以有利地结合到其他医疗装置中。 不透射线的表面毛细纤维可以通过挤出不透射线的聚合物或聚合物复合材料形成。
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公开(公告)号：US08758325B2
公开(公告)日：2014-06-24
申请号：US11409147
申请日：2006-04-21
申请人： Mark W. I. Webster , Jason A. Galdonik , Matthew F. Ogle , Edward Anderson , Gregory A. Boldenow
发明人： Mark W. I. Webster , Jason A. Galdonik , Matthew F. Ogle , Edward Anderson , Gregory A. Boldenow
IPC分类号： A61M31/00
CPC分类号： A61M25/0041 , A61B17/22 , A61B2017/22039 , A61B2217/005 , A61M25/005 , A61M25/0052 , A61M25/0054 , A61M25/0068 , A61M25/007 , A61M25/0074 , A61M25/008 , A61M25/10 , A61M2025/0063 , A61M2025/0183 , A61M2025/1052
摘要： Thrombectomy catheters are presented that have curved tip portions. A suction lumen extends from at or near the proximal end of the catheter to a suction port at or near the tip portion of the catheter. The curves of the thrombectomy catheter can be selected to place a suction port at or near a vessel wall for the more effective removal of thrombus resulting from directing the suction in the direction of the thrombus. In some embodiments, the tip portion of the catheter can be transitioned from a first configuration for delivery of the catheter into the vessel to a second more curved configuration with a desired design for application of suction. The catheter can be moved in a circumferential and/or lateral direction to cover selected portions of the inner vessel wall. In some embodiments, a partially occlusive structure can be used to reduce and/or redirect flow within the vessel to improve performance of the thrombectomy.
摘要翻译： 呈现出具有弯曲尖端部分的血栓切除导管。 吸入腔从导管的近端处或附近延伸到导管尖端部分处或附近的吸入口。 可以选择血栓切除术导管的曲线以将血管口置于血管壁或血管壁附近，以便更有效地从血栓方向引导吸引血栓。 在一些实施例中，导管的尖端部分可以从用于将导管输送到容器中的第一构型转变成具有用于施加抽吸的期望设计的第二更弯曲构造。 导管可以在周向和/或横向移动以覆盖内部血管壁的选定部分。 在一些实施方案中，可以使用部分封闭结构来减少和/或重定向血管内的流动，以改善血栓切除术的性能。
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公开(公告)号：US08382788B2
公开(公告)日：2013-02-26
申请号：US13218183
申请日：2011-08-25
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61F2/01 , A61F2/24 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0093
摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.
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