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33 条记录 (耗时 0.031 秒)

    METHOD OF DETERMINING PROGNOSIS IN PATIENTS WITH FOLLICULAR LYMPHOMA
    1.
    发明申请
    METHOD OF DETERMINING PROGNOSIS IN PATIENTS WITH FOLLICULAR LYMPHOMA 有权

    公开(公告)号：US20210388448A1

    公开(公告)日：2021-12-16

    申请号：US17283215

    申请日：2019-10-14

    申请人： MASARYKOVA UNIVERZITA ,  FAKULTNI NEMOCNICE BRNO

    发明人： Marek MRAZ ,  Jan DEVAN ,  Katerina LITZMANOVIA

    IPC分类号： C12Q1/6886

    摘要： A method is disclosed for determining prognosis for a patient suffering from follicular lymphoma, that determines the amount of miR-31 in a biological sample taken from the body of the patient, and assigns the patient to a prognostic group based on the determined amount of miR-31, wherein the prognostic groups and the threshold values for assignment to the prognostic groups are obtained by analyzing the amount of miR-31 in biological samples of patients with known prognosis. In the biological sample taken from the patient, the miR-31 expression may be determined along with the expression of an endogenous control, which is a small nuclear RNA or stably expressed miRNA, and, in case of absolute quantification, the expression of synthetic standards of these miRNAs and endogenous controls of known number of molecules are determined. The method allows the assignment of patients to prognostic groups by determining miR-31 expression.

    METHOD OF DIAGNOSIS OF COLORECTAL CANCER
    2.
    发明申请
    METHOD OF DIAGNOSIS OF COLORECTAL CANCER 有权

    公开(公告)号：US20210130904A1

    公开(公告)日：2021-05-06

    申请号：US16629520

    申请日：2018-07-13

    申请人： MASARYKOVA UNIVERZITA ,  MASARYKUV ONKOLOGICKY USTAV

    发明人： Ondrej SLABY ,  Petra VYCHYTILOVA ,  Marek SVOBODA ,  Milana SACHLOVA

    IPC分类号： C12Q1/6886

    摘要： Method of diagnosing and prognosing colorectal cancer using piRNA-hsa-5937, having the sequence TCCCTGGTGGTCTAGTGGTTAGGATTCGGCA (SEQ ID NO. 1), as a biomarker, in combination with at least one miRNA selected from: (SEQ ID NO. 3) miR-23a-3p, having the sequence AUCACAUUGCCAGGGAUUUCC, (SEQ ID NO. 4) miR-27a-3p, having the sequence UUCACAGUGGCUAAGUUCCGC, (SEQ ID NO. 5) miR-142-5p, having the sequence CAUAAAGUAGAAAGCACUACU. The resulting method uses a body fluid as the input, is non-invasive, has a high sensitivity and specificity even in very early stages of the disease, and is cost-effective.

    FUROPYRIDINES AS INHIBITORS OF PROTEIN KINASES
    5.
    发明申请
    FUROPYRIDINES AS INHIBITORS OF PROTEIN KINASES 有权
    作为蛋白激酶抑制剂的麝香草

    公开(公告)号：US20170037052A1

    公开(公告)日：2017-02-09

    申请号：US15304043

    申请日：2015-04-29

    申请人： MASARYKOVA UNIVERZITA

    发明人： KAMIL PARUCH ,  Michaela PETRUJOVA ,  Vaclav NEMEC

    IPC分类号： C07D491/048

    CPC分类号： C07D491/048

    摘要： The invention relates to furo[3,2-b]pyridines substituted at least in position 5 as inhibitors of protein kinases, regulators or modulators, methods of preparation thereof, pharmaceutical compositions containing the compounds, and pharmaceutical use of the compounds and compositions in the treatment of the diseases such as, for example, cancer or neurodegenerative diseases.

    摘要翻译： 本发明涉及至少在第5位取代的呋喃并[3,2-b]吡啶，作为蛋白激酶抑制剂，调节剂或调节剂，其制备方法，含该化合物的药物组合物，以及该化合物和组合物在 治疗诸如癌症或神经变性疾病的疾病。

    METHOD OF PLASMA TREATMENT OF AN INTERNAL AND/OR EXTERNAL SURFACE OF A HOLLOW ELECTRICALLY NON-CONDUCTIVE BODY AND A DEVICE FOR CARRYING OUT THIS METHOD
    6.
    发明申请
    METHOD OF PLASMA TREATMENT OF AN INTERNAL AND/OR EXTERNAL SURFACE OF A HOLLOW ELECTRICALLY NON-CONDUCTIVE BODY AND A DEVICE FOR CARRYING OUT THIS METHOD 审中-公开
    等离子体处理中空电导体的内部和/或外部表面的方法以及用于实施该方法的装置

    公开(公告)号：US20160319433A1

    公开(公告)日：2016-11-03

    申请号：US15106005

    申请日：2014-12-18

    申请人： MASARYKOVA UNIVERZITA

    发明人： David PAVLINAK ,  Dusan KOVACIK ,  Mirko CERNAK

    IPC分类号： C23C16/513 ,  H05H1/24

    CPC分类号： C23C16/513 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2001/2418 ,  H05H2001/2431 ,  H05H2001/245

    摘要： A method of plasma treatment of an internal and/or external surface of a hollow electrically non-conductive body. The internal surface of the body and/or its external surface acts a layer of electrical plasma of a surface dielectric barrier discharge generated in a volume of gas by alternating or pulse voltage with an amplitude higher than 100 V from a pair of liquid electrodes formed by an internal electrically conductive liquid situated inside the body and by an external electrically conductive liquid situated outside the body. The electrical plasma is generated above the surface of the electrically conductive liquid, where in the volume of the gas forms a layer of electrical plasma forming a ring copying the shape of the surface of the body wherein the electrical resistance between the liquid electrodes is greater than 10 kΩ. The invention also is a device for carrying out the aforementioned method.

    摘要翻译： 一种等离子体处理中空非导电体内表面和/或外表面的方法。 本体和/或其外表面的内表面通过交替或脉冲电压在一定体积的气体中产生的表面电介质势垒放电层，其电压等于或高于100V的振幅， 位于体内的内部导电液体和位于身体外部的外部导电液体。 在导电液体的表面之上产生电等离子体，其中在气体的体积中形成电等离子体层，形成环，复制了体液表面的形状，其中液体电极之间的电阻大于 10kΩ。 本发明也是用于实施上述方法的装置。