公开(公告)号：US20160130241A1

公开(公告)日：2016-05-12

申请号：US14995803

申请日：2016-01-14

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Craig C. BEESON ,  Christopher C. LINDSEY ,  Yuri K. PETERSON ,  Baerbel ROHRER

IPC分类号： C07D277/56 ,  C07D417/04

CPC分类号： C07D277/56 ,  C07D417/04

摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。

公开(公告)号：US20160237074A1

公开(公告)日：2016-08-18

申请号：US14996662

申请日：2016-01-15

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Craig C. BEESON ,  Baerbel ROHRER ,  Nathan Perron

IPC分类号： C07D417/04

CPC分类号： C07D417/04 ,  C07D401/04 ,  C07D401/06 ,  C07D401/08 ,  C07D417/14

摘要： Disclosed are compounds or pharmaceutically acceptable salts thereof, having the structure of formula I. Also disclosed are methods of preventing and/or treating degenerative disease in a subject, comprising administering to said subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions for preventing and/or treating degenerative disease in a subject comprising a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.

摘要翻译： 公开了具有式I结构的化合物或其药学上可接受的盐。还公开了预防和/或治疗受试者的退行性疾病的方法，包括向所述受试者施用治疗有效量的式I化合物或 其药学上可接受的盐。 还公开了用于预防和/或治疗受试者的退行性疾病的药物组合物，其包含治疗有效量的式I化合物或其药学上可接受的盐。

公开(公告)号：US20150218128A1

公开(公告)日：2015-08-06

申请号：US14685962

申请日：2015-04-14

申请人： MUSC Foundation For Research Development

发明人： Craig C. Beeson ,  Christopher C. Lindsey ,  Yuri K. Peterson ,  Baerbel Rohrer

IPC分类号： C07D401/06 ,  C07D209/36

CPC分类号： C07D401/06 ,  C07D209/34 ,  C07D209/36 ,  C07D209/38 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06

摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。