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公开(公告)号：US20140024677A1
公开(公告)日：2014-01-23
申请号：US13859546
申请日：2013-04-09
IPC分类号： A61K31/4704 , A61K31/138 , A61K31/137
CPC分类号： A61K31/4704 , A61K31/137 , A61K31/138 , A61K31/167
摘要： Methods and compositions for inducing mitochondrial biogenesis are provided. In some aspects, methods for the treatment of diseases such as acute kidney disease (AKI) or a muscle wasting disease by administering tomoxetine, nisoxetine, fenoterol, formoterol, or procaterol to an individual are provided.
摘要翻译： 提供了诱导线粒体生物发生的方法和组合物。 在一些方面，提供了通过向个体施用托莫西汀，尼索西汀，非诺特罗，福莫特罗或丙卡特罗来治疗诸如急性肾脏疾病（AKI）或肌肉消瘦疾病的疾病的方法。
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公开(公告)号：US20210238147A1
公开(公告)日：2021-08-05
申请号：US17238492
申请日：2021-04-23
申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT , The United States Government as Represented by the DEPARTMENT OF VETERANS AFFAIRS
IPC分类号： C07D239/47 , A61P13/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.
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3.发明申请ISATIN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS 有权ISATIN化合物，用于治疗变应性疾病和疾病的组合物和方法公开(公告)号：US20140275075A1
公开(公告)日：2014-09-18
申请号：US13798383
申请日：2013-03-13
IPC分类号： C07D209/36 , C07D403/06 , C07D401/06
CPC分类号： C07D401/06 , C07D209/34 , C07D209/36 , C07D209/38 , C07D401/04 , C07D403/04 , C07D403/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。
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4.发明申请THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS 有权噻唑化合物，治疗变应性疾病和疾病的组合物和方法公开(公告)号：US20160130241A1
公开(公告)日：2016-05-12
申请号：US14995803
申请日：2016-01-14
IPC分类号： C07D277/56 , C07D417/04
CPC分类号： C07D277/56 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。
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5.发明申请THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS 审中-公开噻唑化合物，治疗变应性疾病和疾病的组合物和方法公开(公告)号：US20140275178A1
公开(公告)日：2014-09-18
申请号：US13798421
申请日：2013-03-13
IPC分类号： C07D277/56 , C07D417/04
CPC分类号： C07D277/56 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。
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6.发明申请PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS 有权吡唑化合物，组合物和治疗变应性疾病和疾病的方法公开(公告)号：US20140274950A1
公开(公告)日：2014-09-18
申请号：US13798394
申请日：2013-03-13
IPC分类号： C07D403/06 , C07D403/04 , C07F7/10
CPC分类号： C07F7/0814 , C07D231/14 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07F7/10
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。
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公开(公告)号：US20200055827A1
公开(公告)日：2020-02-20
申请号：US16347163
申请日：2017-11-02
IPC分类号： C07D239/47 , A61P13/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.
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公开(公告)号：US20180134659A1
公开(公告)日：2018-05-17
申请号：US15565820
申请日：2016-04-28
IPC分类号： C07D209/38 , C07D401/12 , A61P27/02 , C07F9/572 , C07D405/12 , C07D209/34 , C07D403/06 , C07D405/06 , C07D401/14 , C07D403/14 , C07D413/06 , C07D498/04
CPC分类号： C07D209/38 , A61P27/02 , C07D209/34 , C07D209/36 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D498/04 , C07F9/5728
摘要： Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
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9.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS 审中-公开化合物，组合物和治疗变应性疾病和疾病的方法公开(公告)号：US20160237074A1
公开(公告)日：2016-08-18
申请号：US14996662
申请日：2016-01-15
发明人： Craig C. BEESON , Baerbel ROHRER , Nathan Perron
IPC分类号： C07D417/04
CPC分类号： C07D417/04 , C07D401/04 , C07D401/06 , C07D401/08 , C07D417/14
摘要： Disclosed are compounds or pharmaceutically acceptable salts thereof, having the structure of formula I. Also disclosed are methods of preventing and/or treating degenerative disease in a subject, comprising administering to said subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions for preventing and/or treating degenerative disease in a subject comprising a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了具有式I结构的化合物或其药学上可接受的盐。还公开了预防和/或治疗受试者的退行性疾病的方法，包括向所述受试者施用治疗有效量的式I化合物或 其药学上可接受的盐。 还公开了用于预防和/或治疗受试者的退行性疾病的药物组合物，其包含治疗有效量的式I化合物或其药学上可接受的盐。
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