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公开(公告)号：US10456400B2
公开(公告)日：2019-10-29
申请号：US15307966
申请日：2015-05-15
IPC分类号： A61K31/519 , C07D471/14
摘要： In some aspects, the present invention relates to aza-ellipticine compounds of the formula: wherein the variables are as defined herein. The application also provides novel methods of preparing aza-ellipticine compounds, methods of using the compounds, and pharmaceutical compositions thereof.
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公开(公告)号：US10370328B2
公开(公告)日：2019-08-06
申请号：US15565820
申请日：2016-04-28
IPC分类号： C07D209/38 , C07D401/06 , C07D403/06 , C07D209/36 , C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D405/06 , C07D413/06 , C07D498/04 , A61P27/02 , C07D209/34 , C07D405/12 , C07F9/572
摘要： Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
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3.发明授权Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders 有权吡唑类化合物，用于治疗退行性疾病和病症的组合物和方法公开(公告)号：US09556207B2
公开(公告)日：2017-01-31
申请号：US14526721
申请日：2014-10-29
IPC分类号： C07D231/14 , C07F7/10 , C07D403/06 , C07D403/04 , C07D401/14 , C07D401/04 , C07D401/06 , C07F7/08
CPC分类号： C07F7/0814 , C07D231/14 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07F7/10
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。
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4.发明授权公开(公告)号：US09981994B2
公开(公告)日：2018-05-29
申请号：US15407748
申请日：2017-01-17
IPC分类号： C07D403/06 , C07F7/08 , C07D401/04 , C07D401/14
CPC分类号： C07F7/0814 , C07D231/14 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07F7/10
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
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5.发明授权公开(公告)号：US09920029B2
公开(公告)日：2018-03-20
申请号：US14685962
申请日：2015-04-14
IPC分类号： C07D209/36 , C07D209/38 , C07D401/06 , C07D403/06 , C07D401/04 , C07D403/04 , C07D209/34
CPC分类号： C07D401/06 , C07D209/34 , C07D209/36 , C07D209/38 , C07D401/04 , C07D403/04 , C07D403/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
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6.发明申请Isatin Compounds, Compositions And Methods For Treatment Of Degenerative Diseases And Disorders 有权靛红化合物，组合物和治疗退行性疾病和疾病的方法公开(公告)号：US20150218128A1
公开(公告)日：2015-08-06
申请号：US14685962
申请日：2015-04-14
IPC分类号： C07D401/06 , C07D209/36
CPC分类号： C07D401/06 , C07D209/34 , C07D209/36 , C07D209/38 , C07D401/04 , C07D403/04 , C07D403/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。
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公开(公告)号：US11939301B2
公开(公告)日：2024-03-26
申请号：US17238492
申请日：2021-04-23
申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT , The United States Government as Represented by the DEPARTMENT OF VETERANS AFFAIRS
IPC分类号： C07D239/47 , A61P13/12 , A61K45/06
CPC分类号： C07D239/47 , A61P13/12 , A61K45/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.
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公开(公告)号：US09970947B2
公开(公告)日：2018-05-15
申请号：US15472414
申请日：2017-03-29
CPC分类号： G01N33/84 , A61K49/0041 , A61K49/0043 , C09B11/24 , G01N21/6428 , G01N33/582 , G01N2021/6432 , G01N2021/6439 , G01N2800/7009 , G01N2800/7019
摘要： Provided herein is a fluorescent probe compound of formula (I): as well as methods of using said compound.
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9.发明申请公开(公告)号：US20170121353A1
公开(公告)日：2017-05-04
申请号：US15407748
申请日：2017-01-17
IPC分类号： C07F7/08 , C07D401/14 , C07D403/06 , C07D401/04
CPC分类号： C07F7/0814 , C07D231/14 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07F7/10
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
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10.发明授权公开(公告)号：US09850218B2
公开(公告)日：2017-12-26
申请号：US14995803
申请日：2016-01-14
IPC分类号： C07D417/04 , C07D277/56
CPC分类号： C07D277/56 , C07D417/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
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