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公开(公告)号：US11324945B2
公开(公告)日：2022-05-10
申请号：US16514772
申请日：2019-07-17
摘要： The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier. A group of the electrode sites may be simultaneously activated to create an activation pattern. The system of the preferred embodiment is preferably designed for deep brain stimulation, and, more specifically, for deep brain stimulation with fine electrode site positioning, selectivity, tunability, and precise activation patterning. The system of the preferred embodiments, however, may be alternatively used in any suitable environment (such as the spinal cord, peripheral nerve, muscle, or any other suitable anatomical location) and for any suitable reason.
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公开(公告)号：US20220031452A1
公开(公告)日：2022-02-03
申请号：US17297315
申请日：2019-11-08
IPC分类号： A61F2/24
摘要： A prosthetic heart valve is disclosed that is deformable between collapsed, radially uncompressed, and target conditions. The prosthetic heart valve includes an inner frame, at least one leaflet, and a braided wire mesh arranged outside and coupled to the inner frame by a coupling portion. The braided wire mesh includes a body portion between the coupling portion and a flared portion. In the radially uncompressed condition, the prosthetic heart valve forms a cavity surrounded by the braided wire mesh and the inner frame. In the target condition, only a part of the length of the body portion is radially compressed along an axis extending from an upstream side to a downstream side. In the collapsed condition, the inner frame and braided wire mesh are radially collapsed over their entire length. In the radially uncompressed condition, the body portion is tubular and the braided wire mesh has a rotationally symmetric circumference.
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公开(公告)号：US10507321B2
公开(公告)日：2019-12-17
申请号：US14952585
申请日：2015-11-25
摘要： In some examples, a medical device system a thin film including at least one electrically conductive track extending between at least one electrode and at least one electrical contact, a first and second polymer layer; wherein, at a portion of the thin film between the at least one electrode and the at least one electrical contact, the first polymer layer and second polymer layer surround the at least one electrically conductive track; and at least one discrete ceramic member located between the first and second polymer layers at a portion of the thin film between the at least one electrode and the at least one electrical contact, wherein the at least one discrete ceramic member does not surround the at least one conductive track, and wherein the at least one discrete ceramic member is configured to increase adhesion between the first polymer layer and second polymer layer.
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公开(公告)号：US09669208B2
公开(公告)日：2017-06-06
申请号：US13128257
申请日：2009-11-09
申请人： Dirk Willem Harberts , Ke Wang , Franciscus Paulus Maria Budzelaar , Hubert Cecile Francois Martens
发明人： Dirk Willem Harberts , Ke Wang , Franciscus Paulus Maria Budzelaar , Hubert Cecile Francois Martens
CPC分类号： A61N1/0534 , A61N1/05 , A61N1/086 , A61N1/3718 , H01B7/048
摘要： The present invention regards a probe for deep brain stimulation (DBS), with high overall impedance, but low overall resistance. This is achieved since the probe comprises a structure comprising at least two interconnected spirals, wherein said two spirals have different direction of rotation. A system for deep brain stimulation comprising the probe, a power source and an electrode is also disclosed.
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公开(公告)号：US09265932B2
公开(公告)日：2016-02-23
申请号：US13575965
申请日：2011-02-02
CPC分类号： A61N1/0534 , A61N1/36082 , A61N1/36185
摘要： A method and control system for determining and applying stimulation settings for a brain stimulation probe (10, 12) is provided. The brain stimulation probe (10, 12) comprises a plurality of stimulation electrodes (11). The method comprises for multiple stimulation electrodes (11) of the plurality of stimulation electrodes (11): applying a test current and determining a corresponding patient response, determining a volume of influence based (32, 52, 71, 91) on the test current and a position of the stimulation electrode (11), combining the volume of influence (32, 52, 71, 91) and the corresponding patient response with generalized anatomic knowledge of stimulation induced behavior for associating the volume of influence (32, 52, 71, 91) to an anatomic structure (33, 43, 53), and determining an intersection (41, 51) of the volume of influence (32, 52, 71, 91) and the associated anatomic structure (33, 43, 53). Then, based on the determined intersections (41, 51) an optimal stimulation volume and corresponding stimulation settings for the brain stimulation probe (10, 12) are determined.
摘要翻译： 提供了一种用于确定和应用脑刺激探针（10,12）的刺激设置的方法和控制系统。 脑刺激探针（10,12）包括多个刺激电极（11）。 该方法包括多个刺激电极（11）的多个刺激电极（11）：施加测试电流并确定相应的患者反应，确定基于（32,52,71,91）的测试电流的影响体积 以及刺激电极（11）的位置，将影响体积（32,52,71,91）和相应的患者反应与刺激诱发行为的广义解剖学知识相结合以影响体积（32,52,71） ，91）到解剖结构（33,43,53），并且确定影响体积（32,52,71,91）和相关联的解剖结构（33,43,53）的交叉点（41,51） 。 然后，基于确定的交叉点（41,51），确定用于脑刺激探针（10,12）的最佳刺激体积和相应的刺激设置。
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公开(公告)号：US09242086B2
公开(公告)日：2016-01-26
申请号：US13574803
申请日：2011-01-20
CPC分类号： A61N1/05 , A61M25/0102 , A61N1/0551
摘要： The invention relates a system (302) for medical stimulation. The system (302) comprises an implantable probe (304) bifurcated into a primary branch (306) and a secondary branch (308) at a bifurcation (310), wherein the probe is provided at its distal end (112, 312) with an electrode (114) for delivering electrical stimulation to tissue. Herein, the primary branch (306) is configured for at least temporarily mechanically co-operating with a guide wire (316) configured for guiding the probe (304) into said tissue whereas the secondary branch (308) is configured for electrically connecting said electrode to a device for generating the electrical stimulation.
摘要翻译： 本发明涉及用于医疗刺激的系统（302）。 系统（302）包括在分叉（310）处分叉成主分支（306）和次分支（308）的可植入探针（304），其中探针在其远端（112,312）处设置有 用于向组织递送电刺激的电极（114）。 这里，主分支（306）被配置为至少临时机械地与被配置为将探针（304）引导到组织中的导丝（316）机械地协作，而辅助分支（308）被配置为电连接所述电极 涉及用于产生电刺激的装置。
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7.发明授权Method and system for determining a threshold for spike detection of electrophysiological signals 有权用于确定电生理信号的尖峰检测阈值的方法和系统公开(公告)号：US09202114B2
公开(公告)日：2015-12-01
申请号：US12993260
申请日：2009-05-25
CPC分类号： G06K9/0053
摘要： A method is provided for determining a threshold (81, 82) for spike (12) detection in an electrophysiological signal (11). The method comprises a step of determining an estimated envelope (31) of the electrophysiological signal (11), a step of, based on the estimated envelope (31), determining an estimated Gaussian noise, a step of determining a distribution (51) of instantaneous amplitudes of the estimated Gaussian noise, a step of determining a mode (61) of the distribution (51) of instantaneous amplitudes, and determining the threshold (81, 82) based on the mode (61) of the distribution (51) of instantaneous amplitudes.
摘要翻译： 提供一种用于确定用于电生理信号（11）中的尖峰（12）检测的阈值（81,82）的方法。 该方法包括确定电生理信号（11）的估计包络（31）的步骤，基于估计包络（31），确定估计的高斯噪声的步骤，确定分布的分布（51）的步骤 估计高斯噪声的瞬时幅度，确定瞬时幅度分布（51）的模式（61）的步骤，以及基于分布（51）的模式（61）确定阈值（81,82） 瞬时振幅。
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公开(公告)号：US10589085B2
公开(公告)日：2020-03-17
申请号：US14377498
申请日：2013-02-05
摘要： A lead for brain applications, comprises at least one distal section and at least one electrode, whereby the at least one electrode is arranged in the distal section and whereby the at least one electrode is connected directly and/or indirectly with at least one first connecting trace and at least one second connecting trace. Furthermore, in some examples, the lead relates to a deep brain stimulation (DBS) system.
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公开(公告)号：US10524681B2
公开(公告)日：2020-01-07
申请号：US14951304
申请日：2015-11-24
发明人： Michel Marcel Jose Decre , Egbertus Reinier Jacobs , Johannes Wilhelmus Weekamp , Marcus Franciscus Donker
IPC分类号： A61N1/05 , A61B5/0478 , A61B5/00
摘要： In one example, a medical device system for at least one of delivery of electrical stimulation pulses or sensing of physiological signals, the system including an elongated carrier; and a thin film wound around the elongated carrier, wherein the thin film includes a plurality of electrical contacts, a plurality of electrodes located distal to the plurality of electrical contacts, and a plurality of conducting tracks, each of the plurality of conducting tracks providing an electrical connection between at least one of the plurality of electrodes and one of the plurality of electrical contacts, and wherein the thin film is wound around the elongated carrier from the distal end of the elongated film to the proximal end of the elongated thin film.
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公开(公告)号：US10058707B2
公开(公告)日：2018-08-28
申请号：US14654352
申请日：2013-12-18
CPC分类号： A61N1/36142 , A61B5/04001 , A61N1/0526 , A61N1/0529 , A61N1/0534 , A61N1/08 , F04C2270/041 , H01L2924/0002 , H01L2924/00
摘要： The present invention relates to an electronic system for a system for neural applications, comprising at least one first connector element and at least one second connector element, the first connector element being configured such that the electronic system is directly and/or indirectly connectable or connected to a controller which is at least configured to supply and/or provide and/or measure at least one voltage and/or at least one current and/or at least one voltage waveform and/or at least one current waveform especially via one or more stimulation outputs and/or recording inputs, the second connector element being configured such that the electronic system is directly and/or indirectly connectable or connected to a lead for neural stimulation and/or recording, wherein the electronic system comprises at least one leakage current detection means configured such that a leakage current, especially a leakage current within and/or around the system for neural applications is detectable.
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