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    Metaxalone products, method of manufacture, and method of use
    1.
    发明授权
    Metaxalone products, method of manufacture, and method of use 有权
    美沙酮产品，制造方法和使用方法

    公开(公告)号：US08168664B2

    公开(公告)日：2012-05-01

    申请号：US12784738

    申请日：2010-05-21

    申请人： Richard H. Roberts ,  Jie Du ,  Matthew W. Davis

    发明人： Richard H. Roberts ,  Jie Du ,  Matthew W. Davis

    IPC分类号： A61K31/42

    CPC分类号： A61K31/421 ,  A61K31/426 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/554 ,  A61K31/56 ,  A61K31/7042 ,  A61K36/38 ,  A61K36/752 ,  A61K36/81 ,  A61K2300/00

    摘要： Disclosed herein are methods of using metaxalone. In one embodiment, the method comprises determining that a patient in need metaxalone therapy is taking a substance that is a n inhibitor or an inducer of a cytochrome p450 isozyme, wherein the cytochrome P450 is CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4, and adjusting administration to the patient of metaxalone or the substance to avoid an adverse event associated with metaxalone. In another embodiment, the method comprises informing a user that metaxalone is metabolized by a cytochrome p450 isozyme, wherein the cytochrome P450 is CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4. Also included are articles of manufacture comprising a container containing a dosage form of metaxalone, wherein the container is associated with published material informing that metaxalone affects activity of a cytochrome p450 isozyme. Also disclosed are a method of treatment and a method of manufacturing a metaxalone product.

    摘要翻译： 本文公开了使用美他沙酮的方法。 在一个实施方案中，所述方法包括确定需要美沙酮治疗的患者正在服用作为细胞色素p450同功酶的抑制剂或诱导物的物质，其中细胞色素P450是CYP1A2，CYP2C8，CYP2C9，CYP2C19，CYP2D6，CYP2E1或 CYP3A4，并调整给予甲氨蝶呤或物质的患者，以避免与metaxalone有关的不良事件。 在另一个实施方案中，该方法包括通知用户，metaxalone被细胞色素p450同功酶代谢，其中细胞色素P450是CYP1A2，CYP2C8，CYP2C9，CYP2C19，CYP2D6，CYP2E1或CYP3A4。 还包括制品，其包含含有美他沙酮剂型的容器，其中所述容器与已发布的材料相关，通知所述metaxalone影响细胞色素p450同功酶的活性。 还公开了治疗方法和制造美他沙酮产品的方法。

    SYSTEM AND METHODS FOR PHARMACY MANAGEMENT OF DRUGS
    2.
    发明申请
    SYSTEM AND METHODS FOR PHARMACY MANAGEMENT OF DRUGS 审中-公开
    药物药物管理系统与方法

    公开(公告)号：US20120065991A1

    公开(公告)日：2012-03-15

    申请号：US13301902

    申请日：2011-11-22

    申请人： Matthew W. Davis

    发明人： Matthew W. Davis

    IPC分类号： G06Q50/22

    CPC分类号： A61K31/165 ,  A61K31/7048 ,  G06Q50/22 ,  Y02A90/22 ,  Y02A90/26 ,  A61K2300/00

    摘要： Described herein is a computer program product for pharmacy management and its application for using drugs that are P-glycoprotein or CYP3A4 inhibitors. Also included is a method of using a first drug in a patient receiving a prescription for the first drug. The computer program performs a method including issuing a drug-drug interaction alert when a patient is receiving a first drug and a concomitantly administered second drug.

    摘要翻译： 本文描述的是用于药物管理的计算机程序产品及其用于使用P-糖蛋白或CYP3A4抑制剂的药物的应用。 还包括在接受第一药物的处方的患者中使用第一药物的方法。 计算机程序执行一种方法，包括在患者接受第一种药物和伴随施用的第二种药物时发出药物 - 药物相互作用警报。

    MEGESTROL ACETATE PRODUCTS, METHOD OF MANUFACTURE, AND METHOD OF USE
    3.
    发明申请
    MEGESTROL ACETATE PRODUCTS, METHOD OF MANUFACTURE, AND METHOD OF USE 失效
    麦芽糖醋酸酯产品，制造方法和使用方法

    公开(公告)号：US20120046262A1

    公开(公告)日：2012-02-23

    申请号：US13271830

    申请日：2011-10-12

    申请人： Matthew William Davis

    发明人： Matthew William Davis

    IPC分类号： A61K31/57 ,  A61P3/00 ,  A61P37/00 ,  A61P35/00 ,  A61P15/00

    CPC分类号： A61K31/57 ,  A61K45/06 ,  A61K2300/00

    摘要： Disclosed herein is a method of using megestrol acetate. In one embodiment, the method comprises informing a user that megestrol acetate is metabolized by a cytochrome p450 isozyme. In another embodiment, the method comprises obtaining megestrol acetate from a container associated with published material providing information is metabolized by a cytochrome p450 siozyme. Also disclosed are articles of manufacture comprising a container containing a dosage form of megestrol acetate, wherein the container is associated with published material informing that megestrol acetate is metabolized by a cytochrome p450 siozyme, a method of treatment, and a method of manufacturing a megestrol acetate product.

    摘要翻译： 本文公开了使用醋酸甲地孕酮的方法。 在一个实施方案中，该方法包括通知用户醋酸甲地孕酮被细胞色素p450同功酶代谢。 在另一个实施方案中，该方法包括从与所公开的材料相关的容器中获得醋酸甲地孕酮，提供信息由细胞色素p450酶代谢。 还公开了包含含有醋酸甲地孕酮剂型的容器的制品，其中容器与已公布的材料相关，通报了醋酸甲地孕酮被细胞色素p450酶代谢，治疗方法和制造醋酸甲地孕酮的方法 产品。

    METAXALONE PRODUCTS, METHOD OF MANUFACTURE, AND METHOD OF USE
    6.
    发明申请
    METAXALONE PRODUCTS, METHOD OF MANUFACTURE, AND METHOD OF USE 有权
    METAXALONE产品，制造方法和使用方法

    公开(公告)号：US20110065721A1

    公开(公告)日：2011-03-17

    申请号：US12784738

    申请日：2010-05-21

    申请人： Richard H. ROBERTS ,  Jie DU ,  Matthew W. DAVIS

    发明人： Richard H. ROBERTS ,  Jie DU ,  Matthew W. DAVIS

    IPC分类号： A61K31/496 ,  A61K31/421 ,  A61P21/00 ,  A61K31/522 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/426

    CPC分类号： A61K31/421 ,  A61K31/426 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/554 ,  A61K31/56 ,  A61K31/7042 ,  A61K36/38 ,  A61K36/752 ,  A61K36/81 ,  A61K2300/00

    摘要： Disclosed herein are methods of using metaxalone. In one embodiment, the method comprises determining that a patient in need metaxalone therapy is taking a substance that is a n inhibitor or an inducer of a cytochrome p450 isozyme, wherein the cytochrome P450 is CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4, and adjusting administration to the patient of metaxalone or the substance to avoid an adverse event associated with metaxalone. In another embodiment, the method comprises informing a user that metaxalone is metabolized by a cytochrome p450 isozyme, wherein the cytochrome P450 is CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4. Also included are articles of manufacture comprising a container containing a dosage form of metaxalone, wherein the container is associated with published material informing that metaxalone affects activity of a cytochrome p450 isozyme. Also disclosed are a method of treatment and a method of manufacturing a metaxalone product.

    摘要翻译： 本文公开了使用美他沙酮的方法。 在一个实施方案中，所述方法包括确定需要美沙酮治疗的患者正在服用作为细胞色素p450同功酶的抑制剂或诱导物的物质，其中细胞色素P450是CYP1A2，CYP2C8，CYP2C9，CYP2C19，CYP2D6，CYP2E1或 CYP3A4，并调整给予甲氨蝶呤或物质的患者，以避免与metaxalone有关的不良事件。 在另一个实施方案中，该方法包括通知用户，metaxalone被细胞色素p450同功酶代谢，其中细胞色素P450是CYP1A2，CYP2C8，CYP2C9，CYP2C19，CYP2D6，CYP2E1或CYP3A4。 还包括制品，其包含含有美他沙酮剂型的容器，其中所述容器与已发布的材料相关，通知所述metaxalone影响细胞色素p450同功酶的活性。 还公开了治疗方法和制造美他沙酮产品的方法。

    COLCHICINE COMPOSITIONS AND METHODS
    8.
    发明申请
    COLCHICINE COMPOSITIONS AND METHODS 有权
    化合物组合物和方法

    公开(公告)号：US20100105780A1

    公开(公告)日：2010-04-29

    申请号：US12687406

    申请日：2010-01-14

    申请人： Matthew W. DAVIS

    发明人： Matthew W. DAVIS

    IPC分类号： A61K31/16

    CPC分类号： A61K31/165 ,  A61K31/16

    摘要： Stable ultrapure colchicine compositions comprising ultrapure colchicine and a pharmaceutically acceptable excipient are described. The compositions can be tablets. Methods for preparing such compositions and methods of use are also disclosed. Methods of treating gout flares with colchicine compositions are also disclosed.

    摘要翻译： 描述了包含超纯秋水仙碱和药学上可接受的赋形剂的稳定的超纯秋水仙碱组合物。 组合物可以是片剂。 还公开了制备这些组合物和使用方法的方法。 还公开了用秋水仙素组合物治疗痛风发作的方法。

    Metaxalone products, method of manufacture, and method of use
    10.
    发明授权
    Metaxalone products, method of manufacture, and method of use 有权
    美沙酮产品，制造方法和使用方法

    公开(公告)号：US07378434B2

    公开(公告)日：2008-05-27

    申请号：US11483332

    申请日：2006-07-07

    申请人： Jie Du ,  Richard H. Roberts

    发明人： Jie Du ,  Richard H. Roberts

    IPC分类号： A61K31/42

    CPC分类号： A61K31/421 ,  A61K45/06 ,  A61K2300/00

    摘要： Disclosed herein is a method of using metaxalone. In one embodiment, the method comprises obtaining metaxalone from a container providing information that metaxalone affects the activity of a cytochrome p450 isozyme. In another embodiment, the method comprises informing a user that metaxalone affects the activity of a cytochrome p450 isozyme. Also included are articles of manufacture comprising a container containing a dosage form of metaxalone, wherein the container is associated with published material informing that metaxalone affects activity of a cytochrome p450 isozyme. Also disclosed are a method of treatment and a method of manufacturing a metaxalone product.

    摘要翻译： 本文公开了使用美他沙酮的方法。 在一个实施方案中，该方法包括从容器中获得metaxalone，其提供metaxalone影响细胞色素p450同功酶活性的信息。 在另一个实施方案中，该方法包括通知用户metaxalone影响细胞色素p450同功酶的活性。 还包括制品，其包含含有美他沙酮剂型的容器，其中所述容器与已发布的材料相关，通知所述metaxalone影响细胞色素p450同功酶的活性。 还公开了治疗方法和制造美他沙酮产品的方法。