公开(公告)号：US11029322B2

公开(公告)日：2021-06-08

申请号：US16446254

申请日：2019-06-19

申请人： NINGBO MEDICAL SYSTEM BIOTECHNOLOGY CO., LTD.

发明人： Jihua Zou ,  Tao Xiong ,  Xiaohui Wu ,  Shangqing Xiao ,  Lei Xu ,  Zhe Feng

IPC分类号： G01N35/00 ,  G01N35/04

摘要： A biochemical analyzer delivery system, comprising a sample feeding track (42), an advancing track (43), a recovery track (44), at least one to-be-tested sub-track (45), at least one emergency sub-track (46) and at least one return sub-track (47); the sample feeding track (42), the advancing track (43) and the recovery track (44) are parallel to each other; the to-be-tested sub-track (45), the emergency sub-track (46) and the return sub-track (47) are disposed between and perpendicular to the sample feeding track (42) and the advancing track (43), an emergency sample may enter the emergency sub-track via the advancing track (43), and then enters the sample feeding track for sample suction. The track-based delivery system can be horizontally disposed in a biochemical analyzer, and can be butt-jointed with a vertical track in the biochemical analyzer, thereby greatly increasing the buffer amount of sample holders without increasing the length of the biochemical analyzer.

公开(公告)号：US20160319248A1

公开(公告)日：2016-11-03

申请号：US15108320

申请日：2014-12-11

申请人： NINGBO MEDICAL SYSTEM BIOTECHNOLOGY CO., LTD.

发明人： Bingde ZOU ,  Jihua ZOU ,  Yi WANG ,  Jianghua JIA

IPC分类号： C12N9/06 ,  G01N33/68

CPC分类号： C12N9/0032 ,  C12Y105/03 ,  G01N33/6842 ,  G01N2333/765 ,  G01N2333/90638 ,  G01N2333/90672

摘要： Fructosyl amino acid oxidase is provided, which has an amino acid sequence as shown in SEQID. No. 1 or fructosyl amino acid oxidase having a homology of more than 80% with this amino acid sequence, on a corresponding site of an amino acid selected from following (a) to (f), having one or more amino acid residues conducting a substitution, obtained fructosyl amino acid oxidase having a higher thermostability: (a) 59-site glutamic acid, (b) 98-site glutamic acid, (c) 225-site glycine, (d) 277-site lysine, (e) 285-site glutamic acid, and (f) 355-site aspartic acid. The method for preparing the above oxidase and the test kit containing the enzyme for determining glycated albumin are also provided.

摘要翻译： 提供了果糖基氨基酸氧化酶，其具有如SEQID所示的氨基酸序列。 1或与该氨基酸序列具有大于80％同源性的果糖基氨基酸氧化酶，在选自以下（a）至（f）的氨基酸的相应位点上具有一个或多个氨基酸残基进行 取代，得到具有较高热稳定性的果糖基氨基酸氧化酶：（a）59位谷氨酸，（b）98位谷氨酸，（c）225位点甘氨酸，（d）277位点赖氨酸，（e）285 谷氨酸，（f）355位天冬氨酸。 还提供了制备上述氧化酶的方法和含有用于测定糖化白蛋白的酶的测试试剂盒。