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公开(公告)号：US09988609B2
公开(公告)日：2018-06-05
申请号：US15108320
申请日：2014-12-11
发明人： Bingde Zou , Jihua Zou , Yi Wang , Jianghua Jia
CPC分类号： C12N9/0032 , C12Y105/03 , G01N33/6842 , G01N2333/765 , G01N2333/90638 , G01N2333/90672
摘要： Fructosyl amino acid oxidase is provided, which has an amino acid sequence as shown in SEQID. No. 1 or fructosyl amino acid oxidase having a homology of more than 80% with this amino acid sequence, on a corresponding site of an amino acid selected from following (a) to (f), having one or more amino acid residues conducting a substitution, obtained fructosyl amino acid oxidase having a higher thermostability: (a) 59-site glutamic acid, (b) 98-site glutamic acid, (c) 225-site glycine, (d) 277-site lysine, (e) 285-site glutamic acid, and (f) 355-site aspartic acid. The method for preparing the above oxidase and the test kit containing the enzyme for determining glycated albumin are also provided.
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公开(公告)号：US09976126B2
公开(公告)日：2018-05-22
申请号：US14862323
申请日：2015-09-23
申请人： AJINOMOTO CO., INC.
发明人： Yuya Kodama , Wataru Hoshino , Kazutoshi Takahashi , Moemi Ito
CPC分类号： C12N9/0022 , C12P7/40 , C12P7/42 , C12Q1/005 , C12Q1/26 , C12Y104/03019 , G01N27/3271 , G01N2333/90638
摘要： The present invention provides a novel enzyme and methods of using the enzyme for measuring glycine concentration. Specifically, the present invention provides an enzyme in which at least one amino acid residue is mutated so as to improve a property of a glycine oxidase which is associated with the measurement of glycine (e.g., activity of glycine oxidase for glycine, thermal stability of glycine oxidase, and substrate specificity of glycine oxidase for glycine,); and a method of analyzing glycine, that includes measuring glycine contained in a test sample using the modified enzyme; and the like.
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公开(公告)号：US09795671B2
公开(公告)日：2017-10-24
申请号：US13395029
申请日：2010-09-07
申请人： Christopher Weston , Lee Charles Claridge , David Adams , David Smith , Nina Westerlund , Max Ole Valdemar Westerlund , Marjo Pihlavisto , Thua Österman , Elina Ainomaija Antikainen
发明人： Christopher Weston , Lee Charles Claridge , David Adams , David Smith , Nina Westerlund , Marjo Pihlavisto , Thua Österman
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08 , A61K31/00 , C07K16/40 , G01N33/68 , A61K31/137 , A61K31/185 , G01N33/573
CPC分类号： A61K39/3955 , A61K31/00 , A61K31/137 , A61K31/185 , A61K2039/505 , C07K16/40 , C07K2317/76 , G01N33/573 , G01N33/6893 , G01N2333/90638 , G01N2800/085
摘要： The present invention relates to inhibitors of VAP-1 and their use as medicaments in treating fibrotic conditions. Furthermore, the present invention relates to a method of diagnosing a fibrotic condition on the basis of elevated level of soluble VAP-1 or SSAO activity in a bodily fluid, and to a kit for use in said diagnostic method.
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公开(公告)号：US20170226559A1
公开(公告)日：2017-08-10
申请号：US15514956
申请日：2015-10-01
发明人： Jeffrey Meyer , Ken Evans , Jian Chen , Suzanne Ackloo , Moyez Dharsee
CPC分类号： C12Q1/26 , A61B5/1127 , A61B5/145 , C07K7/06 , C07K7/08 , C12N9/0022 , C12Q1/68 , C12Y104/03004 , C40B40/10 , G01N33/5008 , G01N2333/90638 , G01N2560/00 , G01N2800/304
摘要： Disclosed is a method for diagnosing a mood disorder or susceptibility to a mood disorder, including depressive disorders and bipolar disorder, from a biological sample taken from a subject. The method includes detecting markers of monoamine oxidase-A (MAO-A) in the biological sample; determining MAO-A concentration from the markers; and correlating the MAO-A concentration in the biological sample to a control group which does not have a mood disorder in order to diagnose or determine susceptibility to the mood disorder in the subject. Also disclosed is a method of detecting peripheral markers of MAO-A for the diagnosis of a mood disorder or susceptibility to a mood disorder. Also provided are polypeptide markers.
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公开(公告)号：US20150361182A1
公开(公告)日：2015-12-17
申请号：US14730897
申请日：2015-06-04
发明人： Peidong Fan , Jong Kang , Amanda Mikels-Vigdal , Lina Yao , Hongyan Zhong
IPC分类号： C07K16/40 , G01N33/573 , A61L31/10
CPC分类号： C07K16/40 , A61K2039/505 , A61L31/10 , C07K2317/76 , G01N33/573 , G01N2333/90638 , G01N2800/325 , G01N2800/326
摘要： Provided herein are methods that relate to a novel therapeutic strategy for treatment of heart and/or cardiovascular diseases. The method includes administration of LOXL2 inhibitors for treating, preventing, or ameliorating at least one symptom associated with heart and/or cardiovascular diseases.
摘要翻译： 本文提供了涉及用于治疗心脏和/或心血管疾病的新型治疗策略的方法。 该方法包括施用LOXL2抑制剂以治疗，预防或改善与心脏和/或心血管疾病相关的至少一种症状。
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6.发明申请FRUCTOSE AMINO ACID OXIDASE, PREPARATION METHOD AND ENZYME-CONTAINING KIT FOR DETECTING GLYCATED ALBUMIN 有权纤维素氨基酸氧化酶，用于检测糖化铝的制备方法和含酶包装试剂盒公开(公告)号：US20160319248A1
公开(公告)日：2016-11-03
申请号：US15108320
申请日：2014-12-11
发明人： Bingde ZOU , Jihua ZOU , Yi WANG , Jianghua JIA
CPC分类号： C12N9/0032 , C12Y105/03 , G01N33/6842 , G01N2333/765 , G01N2333/90638 , G01N2333/90672
摘要： Fructosyl amino acid oxidase is provided, which has an amino acid sequence as shown in SEQID. No. 1 or fructosyl amino acid oxidase having a homology of more than 80% with this amino acid sequence, on a corresponding site of an amino acid selected from following (a) to (f), having one or more amino acid residues conducting a substitution, obtained fructosyl amino acid oxidase having a higher thermostability: (a) 59-site glutamic acid, (b) 98-site glutamic acid, (c) 225-site glycine, (d) 277-site lysine, (e) 285-site glutamic acid, and (f) 355-site aspartic acid. The method for preparing the above oxidase and the test kit containing the enzyme for determining glycated albumin are also provided.
摘要翻译： 提供了果糖基氨基酸氧化酶，其具有如SEQID所示的氨基酸序列。 1或与该氨基酸序列具有大于80％同源性的果糖基氨基酸氧化酶，在选自以下（a）至（f）的氨基酸的相应位点上具有一个或多个氨基酸残基进行 取代，得到具有较高热稳定性的果糖基氨基酸氧化酶：（a）59位谷氨酸，（b）98位谷氨酸，（c）225位点甘氨酸，（d）277位点赖氨酸，（e）285 谷氨酸，（f）355位天冬氨酸。 还提供了制备上述氧化酶的方法和含有用于测定糖化白蛋白的酶的测试试剂盒。
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公开(公告)号：US20160161508A1
公开(公告)日：2016-06-09
申请号：US15043238
申请日：2016-02-12
发明人： Maria ZELLNER , Rudolf OEHLER
CPC分类号： G01N33/6896 , C07K14/4711 , C12Q1/6883 , C12Q2600/158 , G01N2333/90638 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835
摘要： A method for the diagnosis of Alzheimer's Disease (AD) or Parkinson's Disease (PD), including measuring the level of expression of one or more AD markers (Table 1) or PD markers (Table 2) in a sample of platelets isolated from a person suspected of having AD or PD, and determining whether the levels of expression are altered compared to a control.
摘要翻译： 一种用于诊断阿尔茨海默病（AD）或帕金森病（PD）的方法，包括测量从人分离的血小板样品中的一种或多种AD标志物（表1）或PD标志物（表2）的表达水平 怀疑患有AD或PD，并确定与对照相比，表达水平是否改变。
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公开(公告)号：US09353399B2
公开(公告)日：2016-05-31
申请号：US14345137
申请日：2013-03-21
申请人： Kyo Han Ahn , Dokyoung Kim
发明人： Kyo Han Ahn , Dokyoung Kim
IPC分类号： C12Q1/26 , C07C255/42 , C07D311/92 , C07C221/00 , C07C223/06 , C07C255/43 , C07D311/58 , C07F7/18 , C12Q1/42 , C07C253/30
CPC分类号： C12Q1/26 , C07C221/00 , C07C223/06 , C07C253/30 , C07C255/42 , C07C255/43 , C07D311/58 , C07D311/92 , C07F7/1804 , C12Q1/42 , G01N2333/90638 , G01N2800/2835 , G01N2800/304
摘要： Disclosed is a compound which is a two-photon absorbing fluorescent substance, a production method for the compound, a fluorescence sensor and molecular probe able to sense various substrates or enzyme activity or the like using the same, and a method of sensing enzyme activity or the like using the same. The disclosed compound can be used as a fluorescence sensor, and can be used in the study and treatment of diseases in which MAO enzymes are involved such as mood disorders using MAO enzyme activity and inhibitor screening.
摘要翻译： 公开了一种双光子吸收荧光物质的化合物，该化合物的制备方法，荧光传感器和能够感测各种底物或酶活性的分子探针等，以及检测酶活性的方法或 喜欢使用相同的。 所公开的化合物可用作荧光传感器，并且可用于研究和治疗使用MAO酶活性和抑制剂筛选的MAO酶参与的疾病如情绪障碍。
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9.发明申请公开(公告)号：US20140377791A1
公开(公告)日：2014-12-25
申请号：US14345137
申请日：2013-03-21
发明人： Kyo Han Ahn , Dokyoung Kim
IPC分类号： C12Q1/26 , C07C221/00 , C07C255/43 , C07F7/18 , C07D311/58 , C07C223/06
CPC分类号： C12Q1/26 , C07C221/00 , C07C223/06 , C07C253/30 , C07C255/42 , C07C255/43 , C07D311/58 , C07D311/92 , C07F7/1804 , C12Q1/42 , G01N2333/90638 , G01N2800/2835 , G01N2800/304
摘要： The present invention relates to a compound which is a novel two-photon absorbing fluorescent substance, a production method for the compound, a fluorescence sensor and molecular probe able to sense various substrates or enzyme activity or the like using the same, and a method of sensing enzyme activity or the like using the same. More specifically, the present invention relates to a novel two-photon absorbing fluorescent substance which has the high photo-stability and large two-photon absorption cross-section value of acedan which is a two-photon absorbing fluorescent substance, and has the high fluorescence efficiency of coumarin which is a one-photon absorbing fluorescent substance, while exhibiting absorption and emission characteristics at a longer wavelength than existing acedan and coumarin and so being advantageous in in-vivo imaging. The compound according to the present invention can be used as a fluorescence sensor which is highly sensitive and selective for various substrates, and more particularly, can be used in the study and treatment of diseases in which MAO enzymes are involved such as mood disorders using MAO enzyme activity and inhibitor screening.
摘要翻译： 本发明涉及一种新型双光子吸收荧光物质的化合物，该化合物的制备方法，荧光传感器和能够感测各种底物或酶活性等的分子探针，以及使用其的方法 感测酶活性等。 更具体地说，本发明涉及一种新颖的双光子吸收荧光物质，其具有高双光子吸收荧光物质的阿登丹的光稳定性和双光子吸收截面积大，并具有高荧光 作为单光子吸收荧光物质的香豆素的效率，同时具有比现有的氨基和香豆素更长的波长的吸收和发射特性，因此在体内成像方面是有利的。 根据本发明的化合物可以用作对各种底物高度敏感和选择性的荧光传感器，更具体地可以用于研究和治疗涉及MAO酶的疾病，例如使用MAO的情绪障碍 酶活性和抑制剂筛选。
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10.发明申请METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF HAEMORRHAGIC CONVERSION 有权用于治疗和诊断高血压转化的方法和组合公开(公告)号：US20120014939A1
公开(公告)日：2012-01-19
申请号：US13062205
申请日：2009-09-02
CPC分类号： G01N33/573 , C12Q1/26 , G01N2333/90638 , G01N2800/22
摘要： The invention provides a method for predicting a hemorrhagic disorder in a patient consisting determining amine oxidase and, particularly, VAP-1 in a sample from said patient. The invention also provides pharmaceutical compositions comprising an inhibitor of amine oxidase and an antithrombotic agent as well as the use of an inhibitor of amine oxidase for treatment of hemorrhagic disorders.
摘要翻译： 本发明提供了一种用于预测患者出血性疾病的方法，其包括确定所述患者的样品中的胺氧化酶，特别是VAP-1。 本发明还提供了包含胺氧化酶抑制剂和抗血栓形成剂的药物组合物，以及胺氧化酶抑制剂用于治疗失血性疾病的用途。
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