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公开(公告)号：US20140066830A1
公开(公告)日：2014-03-06
申请号：US13801215
申请日：2013-03-13
申请人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
IPC分类号： A61M27/00
CPC分类号： A61M27/006 , A61M1/3679 , A61M25/0026 , A61M2025/0007 , A61M2027/004 , A61M2202/0021 , A61M2202/0464 , A61M2202/203 , A61M2202/206 , A61M2206/16 , A61M2210/0693 , A61M2210/1003
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
摘要翻译： 本发明提供了通过从CSF中除去目标化合物来调节脑脊髓液（CSF）的方法和系统。 该系统提供多空间流动路径并在CSF空间中交换CSF的大部分体积部分。 特定化合物的去除和/或递送可以针对特定疾病的病理学来定制。 移除是针对性的，特异性的，例如通过使用特定的大小排除阈值，针对特定毒素的抗体和其他色谱技术，以及递送和/或去除靶向治疗剂。
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公开(公告)号：US08435204B2
公开(公告)日：2013-05-07
申请号：US12444581
申请日：2007-10-09
申请人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
IPC分类号： A61M1/00
CPC分类号： A61M27/006 , A61M1/3679 , A61M25/0026 , A61M2025/0007 , A61M2027/004 , A61M2202/0021 , A61M2202/0464 , A61M2202/203 , A61M2202/206 , A61M2206/16 , A61M2210/0693 , A61M2210/1003
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. A multilumen flow path allows exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
摘要翻译： 本发明提供了通过从CSF中除去目标化合物来调节脑脊髓液（CSF）的方法和系统。 多腔流路允许在CSF空间中交换CSF的大部分体积部分。 特定化合物的去除和/或递送可以针对特定疾病的病理学来定制。 移除是针对性的，特异性的，例如通过使用特定的大小排除阈值，针对特定毒素的抗体和其他色谱技术，以及递送和/或去除靶向治疗剂。
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公开(公告)号：US20210386981A1
公开(公告)日：2021-12-16
申请号：US17354388
申请日：2021-06-22
申请人： NEUROFLUIDICS, INC.
发明人： SHIVANAND LAD , WILLIAM C. MOBLEY , KAROLY NIKOLICH , THOMAS SAUL
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US11040179B2
公开(公告)日：2021-06-22
申请号：US16548554
申请日：2019-08-22
申请人： NEUROFLUIDICS, INC.
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US09895518B2
公开(公告)日：2018-02-20
申请号：US13801215
申请日：2013-03-13
申请人： Neurofluidics, Inc.
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
CPC分类号： A61M27/006 , A61M1/3679 , A61M25/0026 , A61M2025/0007 , A61M2027/004 , A61M2202/0021 , A61M2202/0464 , A61M2202/203 , A61M2202/206 , A61M2206/16 , A61M2210/0693 , A61M2210/1003
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US20210386982A1
公开(公告)日：2021-12-16
申请号：US17354429
申请日：2021-06-22
申请人： NEUROFLUIDICS, INC.
发明人： SHIVANAND LAD , WILLIAM C. MOBLEY , KAROLY NIKOLICH , THOMAS SAUL
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US11065425B2
公开(公告)日：2021-07-20
申请号：US16548554
申请日：2019-08-22
申请人： NEUROFLUIDICS, INC.
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US20200046954A1
公开(公告)日：2020-02-13
申请号：US16548554
申请日：2019-08-22
申请人： NEUROFLUIDICS, INC.
发明人： SHIVANAND LAD , WILLIAM C. MOBLEY , KAROLY NIKOLICH , THOMAS SAUL
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US10398884B2
公开(公告)日：2019-09-03
申请号：US15410219
申请日：2017-01-19
申请人： NEUROFLUIDICS, INC.
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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