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公开(公告)号：US11040179B2
公开(公告)日：2021-06-22
申请号：US16548554
申请日：2019-08-22
申请人： NEUROFLUIDICS, INC.
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US09895518B2
公开(公告)日：2018-02-20
申请号：US13801215
申请日：2013-03-13
申请人： Neurofluidics, Inc.
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
CPC分类号： A61M27/006 , A61M1/3679 , A61M25/0026 , A61M2025/0007 , A61M2027/004 , A61M2202/0021 , A61M2202/0464 , A61M2202/203 , A61M2202/206 , A61M2206/16 , A61M2210/0693 , A61M2210/1003
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US11065425B2
公开(公告)日：2021-07-20
申请号：US16548554
申请日：2019-08-22
申请人： NEUROFLUIDICS, INC.
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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公开(公告)号：US10398884B2
公开(公告)日：2019-09-03
申请号：US15410219
申请日：2017-01-19
申请人： NEUROFLUIDICS, INC.
发明人： Shivanand Lad , William C. Mobley , Karoly Nikolich , Thomas Saul
摘要： The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
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