公开(公告)号：US11542278B1

公开(公告)日：2023-01-03

申请号：US17514877

申请日：2021-10-29

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： A61K31/4427 ,  C07D471/22 ,  C07D498/22 ,  A61P35/00 ,  C07D513/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds of Formula (I): pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The disclosure further relates to methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof.

公开(公告)号：US20240317771A1

公开(公告)日：2024-09-26

申请号：US18735898

申请日：2024-06-06

申请人： Nuvalent, Inc.

发明人： Sibao CHEN ,  Christopher G. F. COOPER ,  Baudouin GERARD ,  Joshua Courtney HORAN ,  Jason T. KROPP ,  Benjamin Stephen LANE ,  David James PEARSON

IPC分类号： C07D491/22 ,  A61K9/20 ,  A61K9/28

CPC分类号： C07D491/22 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2833 ,  C07B2200/13

摘要： Provided herein are solid forms comprising a compound of formula (I), or a stereoisomer, or a mixture of stereoisomers thereof, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of synthesizing a compound of formula (I), pharmaceutical compositions comprising the same, and methods of treating, preventing, and managing various disorders using the compositions provided herein.

公开(公告)号：US11667649B2

公开(公告)日：2023-06-06

申请号：US17524169

申请日：2021-11-11

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D491/22

CPC分类号： C07D491/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20220098212A1

公开(公告)日：2022-03-31

申请号：US17524169

申请日：2021-11-11

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D491/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof Also disclosed are methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20240352037A1

公开(公告)日：2024-10-24

申请号：US18745209

申请日：2024-06-17

申请人： Nuvalent, Inc.

发明人： Joshua Courtney Horan ,  Xinxing Tang ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Anupong Tangpeerachaikul

IPC分类号： C07D498/22 ,  A61P35/00 ,  C07D513/22

CPC分类号： C07D498/22 ,  A61P35/00 ,  C07D513/22

摘要： Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The disclosure further relates to methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof.

公开(公告)号：US12043626B2

公开(公告)日：2024-07-23

申请号：US17957725

申请日：2022-09-30

申请人： Nuvalent, Inc.

发明人： Sibao Chen ,  Christopher G. F. Cooper ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Jason T. Kropp ,  Benjamin Stephen Lane ,  David James Pearson

IPC分类号： C07D491/22 ,  A61K9/20 ,  A61K9/28

CPC分类号： C07D491/22 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2833 ,  C07B2200/13

摘要： Provided herein are solid forms comprising a compound of formula (I), or a stereoisomer, or a mixture of stereoisomers thereof, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of synthesizing a compound of formula (I), pharmaceutical compositions comprising the same, and methods of treating, preventing, and managing various disorders using the compositions provided herein.

公开(公告)号：US20230124705A1

公开(公告)日：2023-04-20

申请号：US17957725

申请日：2022-09-30

申请人： Nuvalent, Inc.

发明人： Sibao CHEN ,  Christopher G. F. COOPER ,  Baudouin GERARD ,  Joshua Courtney HORAN ,  Jason T. KROPP ,  Benjamin Stephen LANE ,  David James PEARSON

IPC分类号： C07D491/22 ,  A61K9/20 ,  A61K9/28

摘要： Provided herein are solid forms comprising a compound of formula (I), or a stereoisomer, or a mixture of stereoisomers thereof, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of synthesizing a compound of formula (I), pharmaceutical compositions comprising the same, and methods of treating, preventing, and managing various disorders using the compositions provided herein.

公开(公告)号：US12037346B2

公开(公告)日：2024-07-16

申请号：US17718381

申请日：2022-04-12

申请人： Nuvalent, Inc.

发明人： Kristin Lynne Andrews ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Yuting Sun ,  Anupong Tangpeerachaikul

IPC分类号： A61K31/4353 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D519/00 ,  C07D487/04

摘要： Disclosed are amino-substituted heteroaromatic compounds such as a compound of Formula (I):




pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the amino-substituted heteroaromatic compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.

公开(公告)号：US20230322797A1

公开(公告)日：2023-10-12

申请号：US18131581

申请日：2023-04-06

申请人： Nuvalent, Inc.

发明人： Christopher G. F. COOPER ,  Baudouin GERARD ,  Joshua Courtney HORAN ,  Jason T. KROPP ,  Benjamin Stephen LANE ,  David James PEARSON ,  Lauren Ashley MACEACHERN ,  Yameng HE ,  Mandeep SINGH ,  Arkesh NARAYANAPPA

IPC分类号： C07D491/22 ,  C07D401/14 ,  A61K9/20

CPC分类号： C07D491/22 ,  C07D401/14 ,  C07B2200/13 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2054

摘要： Provided herein are solid forms comprising a compound of formula (I), or a stereoisomer, or a mixture of stereoisomers thereof, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of synthesizing a compound of formula (I), pharmaceutical compositions comprising the same, and methods of treating, preventing, and managing various disorders using the compositions provided herein.

公开(公告)号：US20220363696A1

公开(公告)日：2022-11-17

申请号：US17718381

申请日：2022-04-12

申请人： Nuvalent, Inc.

发明人： Kristin Lynne Andrews ,  Baudouin Gerard ,  Joshua Courtney Horan ,  Scot Richard Mente ,  Henry Efrem Pelish ,  Matthew D. Shair ,  Yuting Sun ,  Anupong Tangpeerachaikul

IPC分类号： C07D519/00 ,  C07D487/04

摘要： Disclosed are amino-substituted heteroaromatic compounds such as 4-amino-quinazolines, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the amino-substituted heteroaromatic compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.