公开(公告)号：US5972706A

公开(公告)日：1999-10-26

申请号：US111388

申请日：1998-07-07

申请人： Francis McCormick

发明人： Francis McCormick

IPC分类号： A61K35/76 ,  A61K35/761 ,  A61K48/00 ,  C12N7/00 ,  C12N7/04 ,  C12N15/861 ,  C12N15/01 ,  C12N15/86 ,  A61K31/70

CPC分类号： C12N15/86 ,  A61K35/761 ,  C12N7/00 ,  A61K48/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10362

摘要： Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.