公开(公告)号：US5801029A

公开(公告)日：1998-09-01

申请号：US484938

申请日：1995-06-07

申请人： Francis McCormick

发明人： Francis McCormick

IPC分类号： A61K35/76 ,  A61K35/761 ,  A61K48/00 ,  C12N7/00 ,  C12N7/04 ,  C12N15/861 ,  C12N15/01 ,  C12N15/86 ,  A61K31/70

CPC分类号： C12N15/86 ,  A61K35/761 ,  C12N7/00 ,  A61K48/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10362

摘要： Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

公开(公告)号：US5856181A

公开(公告)日：1999-01-05

申请号：US950275

申请日：1997-10-14

申请人： Francis McCormick

发明人： Francis McCormick

IPC分类号： A61K35/76 ,  A61K35/761 ,  A61K48/00 ,  C12N7/00 ,  C12N7/04 ,  C12N15/861 ,  C12N5/10 ,  C12N7/01 ,  C07H21/04

CPC分类号： C12N15/86 ,  A61K35/761 ,  C12N7/00 ,  A61K48/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10362

摘要： Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

摘要翻译： 提供了通过病毒治疗来治疗肿瘤病症的方法和组合物。 将具有结合和/或失活p53或RB的病毒蛋白的突变病毒给予具有肿瘤的患者，所述肿瘤包含缺乏p53和/或RB功能的细胞。 突变型病毒能够在肿瘤细胞中基本上产生复制表型，但基本上不能在具有基本正常p53和/或RB功能的非复制性非肿瘤细胞中产生复制表型。 在肿瘤细胞中优先产生复制表型导致直接或通过在表达病毒复制表型的细胞中表达细胞毒性基因来赘生性细胞的优先杀伤。

公开(公告)号：US5846945A

公开(公告)日：1998-12-08

申请号：US485037

申请日：1995-06-07

申请人： Francis McCormick

发明人： Francis McCormick

IPC分类号： A61K35/76 ,  A61K35/761 ,  A61K48/00 ,  C12N7/00 ,  C12N7/04 ,  C12N15/861 ,  C12N5/10 ,  C12N7/01 ,  C07H21/04 ,  A61K31/70

CPC分类号： C12N15/86 ,  A61K35/761 ,  C12N7/00 ,  A61K48/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10362

摘要： Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

公开(公告)号：US5972706A

公开(公告)日：1999-10-26

申请号：US111388

申请日：1998-07-07

申请人： Francis McCormick

发明人： Francis McCormick

IPC分类号： A61K35/76 ,  A61K35/761 ,  A61K48/00 ,  C12N7/00 ,  C12N7/04 ,  C12N15/861 ,  C12N15/01 ,  C12N15/86 ,  A61K31/70

CPC分类号： C12N15/86 ,  A61K35/761 ,  C12N7/00 ,  A61K48/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10362

摘要： Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

公开(公告)号：US5677178A

公开(公告)日：1997-10-14

申请号：US641081

申请日：1996-04-29

申请人： Francis McCormick

发明人： Francis McCormick

IPC分类号： A61K35/76 ,  A61K35/761 ,  A61K48/00 ,  C12N7/00 ,  C12N7/04 ,  C12N15/861 ,  C12N5/10 ,  C12N7/01 ,  C07H21/04

CPC分类号： C12N15/86 ,  A61K35/761 ,  C12N7/00 ,  A61K48/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10362

摘要： Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

摘要翻译： 提供了通过病毒治疗来治疗肿瘤病症的方法和组合物。 将具有结合和/或失活p53或RB的病毒蛋白的突变病毒给予具有肿瘤的患者，所述肿瘤包含缺乏p53和/或RB功能的细胞。 突变型病毒能够在肿瘤细胞中基本上产生复制表型，但基本上不能在具有基本正常p53和/或RB功能的非复制性非肿瘤细胞中产生复制表型。 在肿瘤细胞中优先产生复制表型导致直接或通过在表达病毒复制表型的细胞中表达细胞毒性基因来赘生性细胞的优先杀伤。